Skip to main content
Gut logoLink to Gut
. 1989 Jan;30(1):46–49. doi: 10.1136/gut.30.1.46

Abnormal cardiovascular reflexes in patients with gastro-oesophageal reflux.

T K Chakraborty 1, A L Ogilvie 1, R C Heading 1, D J Ewing 1
PMCID: PMC1378229  PMID: 2920926

Abstract

Using five non-invasive tests, abnormalities of cardiovascular reflex function were found in 20 of 50 patients with gastro-oesophageal reflux. Abnormalities of pupil cycle time, an index of non-vagal parasympathetic function, were found in only a few patients, implying that the cardiovascular abnormalities observed were not part of a generalised parasympathetic defect. The findings are consistent with the hypothesis that an abnormality of vagal function may contribute to the pathogenesis of gastro-oesophageal reflux.

Full text

PDF
46

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DeMeester T. R., Wang C. I., Wernly J. A., Pellegrini C. A., Little A. G., Klementschitsch P., Bermudez G., Johnson L. F., Skinner D. B. Technique, indications, and clinical use of 24 hour esophageal pH monitoring. J Thorac Cardiovasc Surg. 1980 May;79(5):656–670. [PubMed] [Google Scholar]
  2. Dodds W. J., Hogan W. J., Stef J. J., Miller W. N., Lydon S. B., Arndorfer R. C. A rapid pull-through technique for measuring lower esophageal sphincter pressure. Gastroenterology. 1975 Mar;68(3):437–443. [PubMed] [Google Scholar]
  3. Ewing D. J., Clarke B. F. Diagnosis and management of diabetic autonomic neuropathy. Br Med J (Clin Res Ed) 1982 Oct 2;285(6346):916–918. doi: 10.1136/bmj.285.6346.916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ewing D. J., Martyn C. N., Young R. J., Clarke B. F. The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care. 1985 Sep-Oct;8(5):491–498. doi: 10.2337/diacare.8.5.491. [DOI] [PubMed] [Google Scholar]
  5. Ewing D. J., Neilson J. M., Travis P. New method for assessing cardiac parasympathetic activity using 24 hour electrocardiograms. Br Heart J. 1984 Oct;52(4):396–402. doi: 10.1136/hrt.52.4.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heatley R. V., Collins R. J., James P. D., Atkinson M. Vagal function in relation to gastro-oesophageal reflux and associated motility changes. Br Med J. 1980 Mar 15;280(6216):755–757. doi: 10.1136/bmj.280.6216.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. King P. M., Pryde A., Heading R. C. Transpyloric fluid movement and antroduodenal motility in patients with gastro-oesophageal reflux. Gut. 1987 May;28(5):545–548. doi: 10.1136/gut.28.5.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Martyn C. N., Ewing D. J. Pupil cycle time: a simple way of measuring an autonomic reflex. J Neurol Neurosurg Psychiatry. 1986 Jul;49(7):771–774. doi: 10.1136/jnnp.49.7.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McCallum R. W., Berkowitz D. M., Lerner E. Gastric emptying in patients with gastroesophageal reflux. Gastroenterology. 1981 Feb;80(2):285–291. [PubMed] [Google Scholar]
  10. Ogilvie A. L., Atkinson M. Influence of the vagus nerve upon the reflex control of the lower oesophageal sphincter. Gut. 1984 Mar;25(3):253–258. doi: 10.1136/gut.25.3.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ogilvie A. L., James P. D., Atkinson M. Impairment of vagal function in reflux oesophagitis. Q J Med. 1985 Jan;54(213):61–74. [PubMed] [Google Scholar]
  12. Smart H. L., Atkinson M. Abnormal vagal function in irritable bowel syndrome. Lancet. 1987 Aug 29;2(8557):475–478. doi: 10.1016/s0140-6736(87)91792-2. [DOI] [PubMed] [Google Scholar]
  13. de Caestecker J. S., Blackwell J. N., Brown J., Heading R. C. The oesophagus as a cause of recurrent chest pain: which patients should be investigated and which tests should be used? Lancet. 1985 Nov 23;2(8465):1143–1146. doi: 10.1016/s0140-6736(85)92676-5. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES