Skip to main content
PMC home page
Gut logoLink to Gut
. 1989 Feb;30(2):223–227. doi: 10.1136/gut.30.2.223

Somatostatin in the treatment of acute pancreatitis: a prospective randomised controlled trial.

T K Choi 1, F Mok 1, W H Zhan 1, S T Fan 1, E C Lai 1, J Wong 1
PMCID: PMC1378305  PMID: 2564834

Abstract

A prospective study was carried out to evaluate the efficacy of somatostatin in the treatment of acute pancreatitis. Seventy one patients were randomised to control (h = 36), or to the somatostatin group (h = 35) who received somatostatin 100 micrograms/h after a 250 microgram bolus for the first two days. The following were compared in the two groups on admission and two days later: laboratory tests of prognostic significance, severity of pancreatitis, and also morbidity and mortality. Of the nine laboratory tests compared, the white blood cell count, lactate dehydrogenase, and urea concentrations were significantly lower in the somatostatin group two days after admission. Severity of pancreatitis after hospitalisation increased in fewer patients given somatostatin (NS). There was a trend toward fewer complications, especially local, in the somatostatin group. Mortality in both groups was low. Somatostatin appeared to reduce the local complications of acute pancreatitis. A larger trial is necessary to show its beneficial effect conclusively.

Full text

PDF
223

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adrian T. E., Barnes A. J., Long R. G., O'Shaughnessy D. J., Brown M. R., Rivier J., Vale W., Blackburn A. M., Bloom S. R. The effect of somatostatin analogs on secretion of growth, pancreatic, and gastrointestinal hormones in man. J Clin Endocrinol Metab. 1981 Oct;53(4):675–681. doi: 10.1210/jcem-53-4-675. [DOI] [PubMed] [Google Scholar]
  2. Baxter J. N., Jenkins S. A., Day D. W., Roberts N. B., Cowell D. C., Mackie C. R., Shields R. Effects of somatostatin and a long-acting somatostatin analogue on the prevention and treatment of experimentally induced acute pancreatitis in the rat. Br J Surg. 1985 May;72(5):382–385. doi: 10.1002/bjs.1800720516. [DOI] [PubMed] [Google Scholar]
  3. Blamey S. L., Imrie C. W., O'Neill J., Gilmour W. H., Carter D. C. Prognostic factors in acute pancreatitis. Gut. 1984 Dec;25(12):1340–1346. doi: 10.1136/gut.25.12.1340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bloom S. R., Mortimer C. H., Thorner M. O., Besser G. M., Hall R., Gomez-Pan A., Roy V. M., Russell R. C., Coy D. H., Kastin A. J. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet. 1974 Nov 9;2(7889):1106–1109. doi: 10.1016/s0140-6736(74)90869-1. [DOI] [PubMed] [Google Scholar]
  5. Dollinger H. C., Raptis S., Pfeiffer E. F. Effects of somatostatin on exocrine and endocrine pancreatic function stimulated by intestinal hormones in man. Horm Metab Res. 1976 Jan;8(1):74–78. doi: 10.1055/s-0028-1093677. [DOI] [PubMed] [Google Scholar]
  6. Hofmann W., Schwille P. O., Engelhardt W., Hemmer J., Scholz D. Somatostatin analogs--effects on gastric stress ulcerations in the rat. Results of a pilot study. Hepatogastroenterology. 1981 Feb;28(1):38–42. [PubMed] [Google Scholar]
  7. Imrie C. W., Benjamin I. S., Ferguson J. C., McKay A. J., Mackenzie I., O'Neill J., Blumgart L. H. A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg. 1978 May;65(5):337–341. doi: 10.1002/bjs.1800650514. [DOI] [PubMed] [Google Scholar]
  8. Imrie C. W., Blumgart L. H. Letter: Glucagon therapy in acute pancreatitis. Br Med J. 1974 Jan 5;1(5896):38–38. doi: 10.1136/bmj.1.5896.38-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Johansson C., Kollberg B., Efendic S., Uvnäs-Wallensten K. Effects of graded doses of somatostatin on gallbladder emptying and pancreatic enzyme output after oral glucose in man. Digestion. 1981;22(1):24–31. doi: 10.1159/000198591. [DOI] [PubMed] [Google Scholar]
  10. Renner I. G., Savage W. T., 3rd, Pantoja J. L., Renner V. J. Death due to acute pancreatitis. A retrospective analysis of 405 autopsy cases. Dig Dis Sci. 1985 Oct;30(10):1005–1018. doi: 10.1007/BF01308298. [DOI] [PubMed] [Google Scholar]
  11. Schrumpf E., Vatn M. H., Hanssen K. F., Myren J. A small dose of somatostatin inhibits the pentagastrin stimulated gastric secretion of acid, pepsin and intrinsic factor in man. Clin Endocrinol (Oxf) 1978 May;8(5):391–395. doi: 10.1111/j.1365-2265.1978.tb02173.x. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES