Skip to main content
NCBI home page
Gut logoLink to Gut
. 1990 Apr;31(4):426–430. doi: 10.1136/gut.31.4.426

Ulcerative colitis: one disease or two? (Quantitative histological differences between distal and extensive disease).

D Jenkins 1, A Goodall 1, B B Scott 1
PMCID: PMC1378417  PMID: 2338268

Abstract

Cell counts and measurements of mucosal architecture were made on rectal biopsies from nine patients with total colitis, eight with left sided colitis, 15 with distal colitis, and 11 with proctitis. The mean total lamina propria cell count in proctitis and distal colitis approached twice that of extensive left sided and total colitis (p less than 0.001) and in distal proctocolitis the cell numbers are further increased in the chronic over the acute phase. This difference was not explained by age, duration, activity, or treatment. The predominantly increased lymphoid and mononuclear cell infiltrate in distal proctocolitis indicates a different pattern of immune response, suggesting a separate process from extensive colitis or a more intense reaction resulting in localisation of disease.

Full text

PDF
426

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison M. C., Hamilton-Dutoit S. J., Dhillon A. P., Pounder R. E. The value of rectal biopsy in distinguishing self-limited colitis from early inflammatory bowel disease. Q J Med. 1987 Dec;65(248):985–995. [PubMed] [Google Scholar]
  2. Barber G. B., Lee D. E., Antonioli D. A., Peppercorn M. A. Refractory distal ulcerative colitis responsive to 5-aminosalicylate enemas. Am J Gastroenterol. 1985 Aug;80(8):612–614. [PubMed] [Google Scholar]
  3. Farmer R. G., Brown C. H. Emerging concepts of proctosigmoiditis. Dis Colon Rectum. 1972 Mar-Apr;15(2):142–146. doi: 10.1007/BF02587263. [DOI] [PubMed] [Google Scholar]
  4. Farmer R. G. Long-term prognosis for patients with ulcerative proctosigmoiditis (ulcerative colitis confirmed to the rectum and sigmoid colon). J Clin Gastroenterol. 1979 Mar;1(1):47–50. doi: 10.1097/00004836-197903000-00006. [DOI] [PubMed] [Google Scholar]
  5. Fléjou J. F., Potet F., Bogomoletz W. V., Rigaud C., Fenzy A., Le Quintrec Y., Goldfain D., Brousse N. Lymphoid follicular proctitis. A condition different from ulcerative proctitis? Dig Dis Sci. 1988 Mar;33(3):314–320. doi: 10.1007/BF01535756. [DOI] [PubMed] [Google Scholar]
  6. Friedman L. S., Richter J. M., Kirkham S. E., DeMonaco H. J., May R. J. 5-Aminosalicylic acid enemas in refractory distal ulcerative colitis: a randomized, controlled trial. Am J Gastroenterol. 1986 Jun;81(6):412–418. [PubMed] [Google Scholar]
  7. Gabrielsson N., Granqvist S., Sundelin P., Thorgeirsson T. Extent of inflammatory lesions in ulcerative colitis assessed by radiology, colonoscopy, and endoscopic biopsies. Gastrointest Radiol. 1979 Nov 15;4(4):395–400. doi: 10.1007/BF01887564. [DOI] [PubMed] [Google Scholar]
  8. Godfrey K. Statistics in practice. Comparing the means of several groups. N Engl J Med. 1985 Dec 5;313(23):1450–1456. doi: 10.1056/NEJM198512053132305. [DOI] [PubMed] [Google Scholar]
  9. Goldman H., Proujansky R. Allergic proctitis and gastroenteritis in children. Clinical and mucosal biopsy features in 53 cases. Am J Surg Pathol. 1986 Feb;10(2):75–86. doi: 10.1097/00000478-198602000-00001. [DOI] [PubMed] [Google Scholar]
  10. Holdstock G., DuBoulay C. E., Smith C. L. Survey of the use of colonoscopy in inflammatory bowel disease. Dig Dis Sci. 1984 Aug;29(8):731–734. doi: 10.1007/BF01312946. [DOI] [PubMed] [Google Scholar]
  11. Jenkins D., Goodall A., Drew K., Scott B. B. What is colitis? Statistical approach to distinguishing clinically important inflammatory change in rectal biopsy specimens. J Clin Pathol. 1988 Jan;41(1):72–79. doi: 10.1136/jcp.41.1.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LENNARD-JONES J. E., COOPER G. W., NEWELL A. C., WILSON C. W., JONES F. A. Observations on idiopathic proctitis. Gut. 1962 Sep;3:201–206. doi: 10.1136/gut.3.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Myers A., Humphreys D. M., Cox E. V. A ten-year follow-up of haemorrhagic proctitis. Postgrad Med J. 1976 Apr;52(606):224–228. doi: 10.1136/pgmj.52.606.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Niv Y., Bat L., Ron E., Theodor E. Change in the extent of colonic involvement in ulcerative colitis: a colonoscopic study. Am J Gastroenterol. 1987 Oct;82(10):1046–1051. [PubMed] [Google Scholar]
  15. Powell-Tuck J., Ritchie J. K., Lennard-Jones J. E. The prognosis of idiopathic proctitis. Scand J Gastroenterol. 1977;12(6):727–732. doi: 10.3109/00365527709181711. [DOI] [PubMed] [Google Scholar]
  16. Ritchie J. K., Powell-Tuck J., Lennard-Jones J. E. Clinical outcome of the first ten years of ulcerative colitis and proctitis. Lancet. 1978 May 27;1(8074):1140–1143. doi: 10.1016/s0140-6736(78)90312-4. [DOI] [PubMed] [Google Scholar]
  17. Scott B. B., Goodall A., Stephenson P., Jenkins D. Rectal mucosal plasma cells in inflammatory bowel disease. Gut. 1983 Jun;24(6):519–524. doi: 10.1136/gut.24.6.519. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES