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. 1990 Jun;31(6):694–697. doi: 10.1136/gut.31.6.694

Relation between zinc status and hepatic functional reserve in patients with liver disease.

H F Goode 1, J Kelleher 1, B E Walker 1
PMCID: PMC1378499  PMID: 2379875

Abstract

Patients with liver disease may be at risk of zinc depletion. We measured polymorphonuclear cell, mononuclear cell, plasma, and erythrocyte zinc values, and erythrocyte carbonic anhydrase activity to assess zinc status in 17 patients with non-alcoholic liver disease (primary biliary cirrhosis and chronic active hepatitis) and 13 patients with alcoholic liver disease. The plasma zinc concentration was reduced in both patient groups and correlated strongly with the plasma albumin concentration. The mean polymorphonuclear cell zinc value in both groups was similar to that of controls but when results were combined and grouped according to hepatic functional reserve, patients with more severe liver damage (grade C) had a lower polymorphonuclear cell zinc value (mean (SD) 0.86 (0.24) nmol/mg protein) than patients with grade A (1.44 (0.43) nmol/mg protein, p less than 0.01) or grade B liver damage (1.08 (0.30) nmol/mg protein, p less than 0.05), or control subjects (1.26 (0.28) nmol/mg protein, p less than 0.001). The polymorphonuclear cell zinc value did not correlate with other indices of zinc status. The mononuclear cell zinc value was normal in all patients and was unrelated to hepatic damage. The erythrocyte zinc value and carbonic anhydrase activity were raised in alcoholic patients only. Since the polymorphonuclear cell zinc concentration is low in human experimental zinc deficiency and also correlates with tissue zinc, we suggest that our results provide evidence of progressive leucocyte zinc depletion in patients with liver disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beerbower K. S., Raess B. U. Erythrocyte, plasma, urine and dialysate zinc levels in patients on continuous ambulatory peritoneal dialysis. Am J Clin Nutr. 1985 Apr;41(4):697–702. doi: 10.1093/ajcn/41.4.697. [DOI] [PubMed] [Google Scholar]
  2. Bode J. C., Hanisch P., Henning H., Koenig W., Richter F. W., Bode C. Hepatic zinc content in patients with various stages of alcoholic liver disease and in patients with chronic active and chronic persistent hepatitis. Hepatology. 1988 Nov-Dec;8(6):1605–1609. doi: 10.1002/hep.1840080622. [DOI] [PubMed] [Google Scholar]
  3. Dawson J. B., Walker B. E. Direct determination of zinc in whole blood, plasma and urine by atomic absorption spectroscopy. Clin Chim Acta. 1969 Dec;26(3):465–475. doi: 10.1016/0009-8981(69)90075-8. [DOI] [PubMed] [Google Scholar]
  4. FREDRICKS R. E., TANAKA K. R., VALENTINE W. N. Zinc in human blood cells: normal values and abnormalities associated with liver disease. J Clin Invest. 1960 Nov;39:1651–1656. doi: 10.1172/JCI104188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Giroux E., Schechter P. J., Schoun J., Sjoerdsma A. Reduced binding of added zinc in serum of patients with decompensated hepatic cirrhosis. Eur J Clin Invest. 1977 Feb;7(1):71–73. doi: 10.1111/j.1365-2362.1977.tb01573.x. [DOI] [PubMed] [Google Scholar]
  6. Goode H. F., Kelleher J., Walker B. E. Zinc concentrations in pure populations of peripheral blood neutrophils, lymphocytes and monocytes. Ann Clin Biochem. 1989 Jan;26(Pt 1):89–95. doi: 10.1177/000456328902600114. [DOI] [PubMed] [Google Scholar]
  7. Jones R. B., Keeling P. W., Hilton P. J., Thompson R. P. The relationship between leucocyte and muscle zinc in health and disease. Clin Sci (Lond) 1981 Feb;60(2):237–239. doi: 10.1042/cs0600237. [DOI] [PubMed] [Google Scholar]
  8. Karayalcin S., Arcasoy A., Uzunalimoglu O. Zinc plasma levels after oral zinc tolerance test in nonalcoholic cirrhosis. Dig Dis Sci. 1988 Sep;33(9):1096–1102. doi: 10.1007/BF01535784. [DOI] [PubMed] [Google Scholar]
  9. Keeling P. W., Jones R. B., Hilton P. J., Thompson R. P. Reduced leucocyte zinc in liver disease. Gut. 1980 Jul;21(7):561–564. doi: 10.1136/gut.21.7.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McClain C. J., Su L. C. Zinc deficiency in the alcoholic: a review. Alcohol Clin Exp Res. 1983 Winter;7(1):5–10. doi: 10.1111/j.1530-0277.1983.tb05402.x. [DOI] [PubMed] [Google Scholar]
  11. Pugh R. N., Murray-Lyon I. M., Dawson J. L., Pietroni M. C., Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973 Aug;60(8):646–649. doi: 10.1002/bjs.1800600817. [DOI] [PubMed] [Google Scholar]
  12. Shapira E., Ben-Yoseph Y., Eyal F. G., Russell A. Enzymatically inactive red cell carbonic anhydrase B in a family with renal tubular acidosis. J Clin Invest. 1974 Jan;53(1):59–63. doi: 10.1172/JCI107559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Swaminathan R., Segall N. H., Chapman C., Morgan D. B. Red-blood-cell composition in thyroid disease. Lancet. 1976 Dec 25;2(8000):1382–1385. doi: 10.1016/s0140-6736(76)91920-6. [DOI] [PubMed] [Google Scholar]
  14. Valberg L. S., Flanagan P. R., Ghent C. N., Chamberlain M. J. Zinc absorption and leukocyte zinc in alcoholic and nonalcoholic cirrhosis. Dig Dis Sci. 1985 Apr;30(4):329–333. doi: 10.1007/BF01403841. [DOI] [PubMed] [Google Scholar]
  15. Walker B. E., Dawson J. B., Kelleher J., Losowsky M. S. Plasma and urinary zinc in patients with malabsorption syndromes or hepatic cirrhosis. Gut. 1973 Dec;14(12):943–948. doi: 10.1136/gut.14.12.943. [DOI] [PMC free article] [PubMed] [Google Scholar]

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