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. 1990 Jun;31(6):714–716. doi: 10.1136/gut.31.6.714

Protracted enteric cryptosporidial infection in selective immunoglobulin A and saccharomyces opsonin deficiencies.

M R Jacyna 1, J Parkin 1, R Goldin 1, J H Baron 1
PMCID: PMC1378504  PMID: 2379877

Abstract

Chronic cryptosporidial infection in man usually occurs in those who are immunocompromised. We report a patient with a one year history of bowel symptoms resulting from persistent cryptosporidial infection of the colon. Investigations showed underlying selective IgA and saccharomyces opsonin deficiencies but no evidence of cell mediated immune dysfunction. Both selective immunoglobulin A and opsonin deficiencies are relatively common in the general population and may be a cause of susceptibility to persistent cryptosporidial infection.

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Selected References

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  1. Ament M. E., Rubin C. E. Relation of giardiasis to abnormal intestinal structure and function in gastrointestinal immunodeficiency syndromes. Gastroenterology. 1972 Feb;62(2):216–226. [PubMed] [Google Scholar]
  2. Ammann A. J., Hong R. Selective IgA deficiency: presentation of 30 cases and a review of the literature. Medicine (Baltimore) 1971 May;50(3):223–236. [PubMed] [Google Scholar]
  3. Campbell P. N., Current W. L. Demonstration of serum antibodies to Cryptosporidium sp. in normal and immunodeficient humans with confirmed infections. J Clin Microbiol. 1983 Jul;18(1):165–169. doi: 10.1128/jcm.18.1.165-169.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Current W. L., Reese N. C., Ernst J. V., Bailey W. S., Heyman M. B., Weinstein W. M. Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission. N Engl J Med. 1983 May 26;308(21):1252–1257. doi: 10.1056/NEJM198305263082102. [DOI] [PubMed] [Google Scholar]
  5. Hart C. A., Baxby D., Blundell N. Gastro-enteritis due to Cryptosporidium: a prospective survey in a children's hospital. J Infect. 1984 Nov;9(3):264–270. doi: 10.1016/s0163-4453(84)90574-7. [DOI] [PubMed] [Google Scholar]
  6. Hunt D. A., Shannon R., Palmer S. R., Jephcott A. E. Cryptosporidiosis in an urban community. Br Med J (Clin Res Ed) 1984 Sep 29;289(6448):814–816. doi: 10.1136/bmj.289.6448.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Janoff E. N., Reller L. B. Cryptosporidium species, a protean protozoan. J Clin Microbiol. 1987 Jun;25(6):967–975. doi: 10.1128/jcm.25.6.967-975.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jokipii L., Jokipii A. M. Timing of symptoms and oocyst excretion in human cryptosporidiosis. N Engl J Med. 1986 Dec 25;315(26):1643–1647. doi: 10.1056/NEJM198612253152604. [DOI] [PubMed] [Google Scholar]
  9. Jokipii L., Pohjola S., Jokipii A. M. Cryptosporidium: a frequent finding in patients with gastrointestinal symptoms. Lancet. 1983 Aug 13;2(8346):358–361. doi: 10.1016/s0140-6736(83)90341-0. [DOI] [PubMed] [Google Scholar]
  10. Lacey C. J., Pinching A. J. Concurrent hepatitis B and disseminated gonococcal infection associated with defective opsonisation. Lancet. 1988 Jan 23;1(8578):185–185. doi: 10.1016/s0140-6736(88)92761-4. [DOI] [PubMed] [Google Scholar]
  11. Oxelius V. A., Laurell A. B., Lindquist B., Golebiowska H., Axelsson U., Björkander J., Hanson L. A. IgG subclasses in selective IgA deficiency: importance of IgG2-IgA deficiency. N Engl J Med. 1981 Jun 11;304(24):1476–1477. doi: 10.1056/NEJM198106113042408. [DOI] [PubMed] [Google Scholar]
  12. Soave R., Danner R. L., Honig C. L., Ma P., Hart C. C., Nash T., Roberts R. B. Cryptosporidiosis in homosexual men. Ann Intern Med. 1984 Apr;100(4):504–511. doi: 10.7326/0003-4819-100-4-504. [DOI] [PubMed] [Google Scholar]
  13. Soothill J. F., Harvey B. A. A defect of the alternative pathway of complement. Clin Exp Immunol. 1977 Jan;27(1):30–33. [PMC free article] [PubMed] [Google Scholar]
  14. Turner M. W., Seymour N. D., Kazatchkine M. D., Mowbray J. F. Suboptimal C3b/C3bi deposition and defective yeast opsonization. II. Partial purification and preliminary characterization of an opsonic co-factor able to correct sera with the defect. Clin Exp Immunol. 1985 Nov;62(2):435–441. [PMC free article] [PubMed] [Google Scholar]
  15. Weisburger W. R., Hutcheon D. F., Yardley J. H., Roche J. C., Hillis W. D., Charache P. Cryptosporidiosis in an immunosuppressed renal-transplant recipient with IgA deficiency. Am J Clin Pathol. 1979 Sep;72(3):473–478. doi: 10.1093/ajcp/72.3.473. [DOI] [PubMed] [Google Scholar]
  16. Whiteside M. E., Barkin J. S., May R. G., Weiss S. D., Fischl M. A., MacLeod C. L. Enteric coccidiosis among patients with the acquired immunodeficiency syndrome. Am J Trop Med Hyg. 1984 Nov;33(6):1065–1072. doi: 10.4269/ajtmh.1984.33.1065. [DOI] [PubMed] [Google Scholar]
  17. Wolfson J. S., Richter J. M., Waldron M. A., Weber D. J., McCarthy D. M., Hopkins C. C. Cryptosporidiosis in immunocompetent patients. N Engl J Med. 1985 May 16;312(20):1278–1282. doi: 10.1056/NEJM198505163122002. [DOI] [PubMed] [Google Scholar]

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