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. 1990 Jul;31(7):817–820. doi: 10.1136/gut.31.7.817

Enhanced intestinal glucose and alanine transport in cystic fibrosis.

P Baxter 1, J Goldhill 1, J Hardcastle 1, P T Hardcastle 1, C J Taylor 1
PMCID: PMC1378543  PMID: 2370017

Abstract

The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.

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Selected References

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  1. Berschneider H. M., Knowles M. R., Azizkhan R. G., Boucher R. C., Tobey N. A., Orlando R. C., Powell D. W. Altered intestinal chloride transport in cystic fibrosis. FASEB J. 1988 Jul;2(10):2625–2629. doi: 10.1096/fasebj.2.10.2838365. [DOI] [PubMed] [Google Scholar]
  2. Boyd C. A. Absence of secretory response in jejunal biopsy samples from children with cystic fibrosis. Lancet. 1987 Aug 15;2(8555):389–389. doi: 10.1016/s0140-6736(87)92402-0. [DOI] [PubMed] [Google Scholar]
  3. Debnam E. S., Levin R. J. An experimental method of identifying and quantifying the active transfer electrogenic component from the diffusive component during sugar absorption measured in vivo. J Physiol. 1975 Mar;246(1):181–196. doi: 10.1113/jphysiol.1975.sp010885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eggermont E. The role of the small intestine in cystic fibrosis patients. Acta Paediatr Scand Suppl. 1985;317:16–21. doi: 10.1111/j.1651-2227.1985.tb14929.x. [DOI] [PubMed] [Google Scholar]
  5. Frase L. L., Strickland A. D., Kachel G. W., Krejs G. J. Enhanced glucose absorption in the jejunum of patients with cystic fibrosis. Gastroenterology. 1985 Feb;88(2):478–484. doi: 10.1016/0016-5085(85)90510-4. [DOI] [PubMed] [Google Scholar]
  6. Giráldez F., Sepúlveda F. V. Changes in the apparent chloride permeability of Necturus enterocytes during the sodium-coupled transport of alanine. Biochim Biophys Acta. 1987 Apr 9;898(2):248–252. doi: 10.1016/0005-2736(87)90044-7. [DOI] [PubMed] [Google Scholar]
  7. Hendrix T. R., Bayless T. M. Digestion: intestinal secretion. Annu Rev Physiol. 1970;32:139–164. doi: 10.1146/annurev.ph.32.030170.001035. [DOI] [PubMed] [Google Scholar]
  8. Luppa D., Hartenstein H., Müller F. Relation between microvilli membrane potential and glucose transport capacity of rat small intestine. Biomed Biochim Acta. 1987;46(5):341–348. [PubMed] [Google Scholar]
  9. Milla P. J., Kilby A., Rassam U. B., Ersser R., Harries J. T. Small intestinal absorption of amino acids and a dipeptide in pancreatic insufficiency. Gut. 1983 Sep;24(9):818–824. doi: 10.1136/gut.24.9.818. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Morin C. L., Roy C. C., Lasalle R., Bonin A. Small bowel mucosal dysfunction in patients with cystic fibrosis. J Pediatr. 1976 Feb;88(2):213–216. doi: 10.1016/s0022-3476(76)80984-5. [DOI] [PubMed] [Google Scholar]
  11. Smyth D. H., Wright E. M. Streaming potentials in the rat small intestine. J Physiol. 1966 Feb;182(3):591–602. doi: 10.1113/jphysiol.1966.sp007839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Taylor C. J., Baxter P. S., Hardcastle J., Hardcastle P. T. Absence of secretory response in jejunal biopsy samples from children with cystic fibrosis. Lancet. 1987 Jul 11;2(8550):107–108. doi: 10.1016/s0140-6736(87)92781-4. [DOI] [PubMed] [Google Scholar]
  13. Taylor C. J., Baxter P. S., Hardcastle J., Hardcastle P. T. Failure to induce secretion in jejunal biopsies from children with cystic fibrosis. Gut. 1988 Jul;29(7):957–962. doi: 10.1136/gut.29.7.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Welsh M. J., Fick R. B. Cystic fibrosis. J Clin Invest. 1987 Dec;80(6):1523–1526. doi: 10.1172/JCI113237. [DOI] [PMC free article] [PubMed] [Google Scholar]

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