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. 1990 Aug;31(8):909–912. doi: 10.1136/gut.31.8.909

Glutathione S-transferases in alcoholic liver disease.

D J Harrison 1, L May 1, P C Hayes 1, M M Haque 1, J D Hayes 1
PMCID: PMC1378621  PMID: 2387516

Abstract

There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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