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. 1990 Sep;31(9):1021–1024. doi: 10.1136/gut.31.9.1021

Effect of ulcerative colitis and smoking on rectal blood flow.

E D Srivastava 1, M A Russell 1, C Feyerabend 1, J Rhodes 1
PMCID: PMC1378661  PMID: 2210447

Abstract

Rectal blood flow was measured by laser doppler flowmetry over 60 minutes in eight patients with colitis in remission and eight healthy male non-smokers. Ten smokers were also examined on two occasions, one of which included smoking a cigarette. Plasma nicotine concentrations were measured in smokers. All subjects showed a pronounced fall in rectal blood flow in the first 30 minutes and patients with colitis had significantly higher values compared with smokers (p less than 0.002; p less than 0.04) and non-smokers (p less than 0.007; p less than 0.002) during the first and second 30 minutes respectively. Values in smokers and non-smokers were similar, but smoking a cigarette was associated with a significant fall in blood flow (p less than 0.04) and this change was inversely related to the rise in plasma nicotine concentration (r = -0.63; p less than 0.05). The findings may be relevant to the association between colitis and the smoking history.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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