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. 1990 Sep;31(9):1033–1036. doi: 10.1136/gut.31.9.1033

Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity.

J E Crabtree 1, L D Juby 1, R V Heatley 1, A J Lobo 1, D W Bullimore 1, A T Axon 1
PMCID: PMC1378664  PMID: 2210449

Abstract

Serum concentrations of soluble interleukin-2 receptor (sIL-2R) were measured as a marker of immune activation in a group of 30 patients with Crohn's disease. sIL-2R concentrations were determined by enzyme linked immunosorbent assay during periods of active and inactive disease and correlated with standard parameters of disease activity. Serum concentrations of sIL-2R were significantly raised in patients with active Crohn's disease compared with patients with inactive disease (p less than 0.001) and control subjects. There was a significant correlation between serum sIL-2R concentrations and disease activity as assessed by the Harvey-Bradshaw index (r = 0.42, p less than 0.01), platelet numbers (r = 0.49, p less than 0.01), and orosomucoid (r = 0.47, p less than 0.01), alpha 1 antitrypsin (r = 0.44, p less than 0.01), and C reactive protein concentrations (r = 0.48, p less than 0.001) but not with the erythrocyte sedimentation rate. Measurement of serum sIL-2R concentration is a simple and useful laboratory means of assessing disease activity. Raised concentrations in patients with active Crohn's disease is further evidence for in vivo immune activation occurring in this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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