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. 1990 Oct;31(10):1093–1096. doi: 10.1136/gut.31.10.1093

Gastroduodenal mucosa in uraemia: endoscopic and histological correlation and prevalence of helicobacter-like organisms.

A Wee 1, J Y Kang 1, M S Ho 1, H L Choong 1, A Y Wu 1, I H Sutherland 1
PMCID: PMC1378730  PMID: 2083853

Abstract

This study aimed to determine the prevalence of endoscopic and histological gastroduodenitis as well as helicobacter-like organisms in patients with end stage renal failure undergoing maintenance dialysis treatment. A total of 322 out of 422 patients in our dialysis programme underwent endoscopy and gastroduodenal biopsy specimens were taken from 260. Endoscopic gastroduodenitis occurred in 158 (49%). Histological gastritis occurred in the gastric body or antrum in 134 patients (52%) and duodenitis in 52 (21%). There was no correlation between endoscopic and histological gastritis in contrast to a significant correlation for duodenitis. Helicobacter-like organisms occurred in the body or antrum in 81 (31%). Their presence was associated with gastritis--in particular acute and acute on chronic gastritis rather than chronic gastritis. Patients with gastritis were significantly older than those without (p less than 0.001) and had lower basal and peak acid outputs.

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Selected References

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  1. Ala-Kaila K. Upper gastrointestinal findings in chronic renal failure. Scand J Gastroenterol. 1987 Apr;22(3):372–376. doi: 10.3109/00365528709078607. [DOI] [PubMed] [Google Scholar]
  2. Andriulli A., Malfi B., Recchia S., Ponti V., Triolo G., Segoloni G. Patients with chronic renal failure are not at a risk of developing chronic peptic ulcers. Clin Nephrol. 1985 May;23(5):245–248. [PubMed] [Google Scholar]
  3. Elta G. H., Appelman H. D., Behler E. M., Wilson J. A., Nostrant T. J. A study of the correlation between endoscopic and histological diagnoses in gastroduodenitis. Am J Gastroenterol. 1987 Aug;82(8):749–753. [PubMed] [Google Scholar]
  4. Franzin G., Musola R., Ghidini O., Manfrini C., Fratton A. Nodular hyperplasia of Brunner's glands. Gastrointest Endosc. 1985 Dec;31(6):374–378. doi: 10.1016/s0016-5107(85)72251-1. [DOI] [PubMed] [Google Scholar]
  5. Franzin G., Musola R., Mencarelli R. Morphological changes of the gastroduodenal mucosa in regular dialysis uraemic patients. Histopathology. 1982 Jul;6(4):429–437. doi: 10.1111/j.1365-2559.1982.tb02740.x. [DOI] [PubMed] [Google Scholar]
  6. Garg A. K., Gulati P. D., Misra R. C., Saha M. M., Rizvi S. N., Chauhan L. C. Gastric functions in chronic uraemia and effects of dialysis. Indian J Gastroenterol. 1984 Apr;3(2):73–75. [PubMed] [Google Scholar]
  7. Graham D. Y., Klein P. D. Campylobacter pyloridis gastritis: the past, the present, and speculations about the future. Am J Gastroenterol. 1987 Apr;82(4):283–286. [PubMed] [Google Scholar]
  8. Hadjiyannakis E. J., Smellie W. A., Evans D. B., Calne R. Y. Gastrointestinal complications after renal transplantation. Lancet. 1971 Oct 9;2(7728):781–785. doi: 10.1016/s0140-6736(71)92739-5. [DOI] [PubMed] [Google Scholar]
  9. Kang J. Y., Wu A. Y., Sutherland I. H., Vathsala A. Prevalence of peptic ulcer in patients undergoing maintenance hemodialysis. Dig Dis Sci. 1988 Jul;33(7):774–778. doi: 10.1007/BF01550962. [DOI] [PubMed] [Google Scholar]
  10. Lambert J. R., Yeomans N. D. Campylobacter pylori--gastroduodenal pathogen or opportunistic bystander? Aust N Z J Med. 1988 Jun;18(4):555–556. doi: 10.1111/j.1445-5994.1988.tb00123.x. [DOI] [PubMed] [Google Scholar]
  11. Margolis D. M., Saylor J. L., Geisse G., DeSchryver-Kecskemeti K., Harter H. R., Zuckerman G. R. Upper gastrointestinal disease in chronic renal failure. A prospective evaluation. Arch Intern Med. 1978 Aug;138(8):1214–1217. [PubMed] [Google Scholar]
  12. Marshall B. J. Campylobacter pyloridis and gastritis. J Infect Dis. 1986 Apr;153(4):650–657. doi: 10.1093/infdis/153.4.650. [DOI] [PubMed] [Google Scholar]
  13. McNulty C. A., Gearty J. C., Crump B., Davis M., Donovan I. A., Melikian V., Lister D. M., Wise R. Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J (Clin Res Ed) 1986 Sep 13;293(6548):645–649. doi: 10.1136/bmj.293.6548.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Milito G., Taccone-Gallucci M., Brancaleone C., Nardi F., Cesca D., Boffo V., Casciani C. U. The gastrointestinal tract in uremic patients on long-term hemodialysis. Kidney Int Suppl. 1985 Dec;17:S157–S160. [PubMed] [Google Scholar]
  15. Milito G., Taccone-Gallucci M., Brancaleone C., Nardi F., Filingeri V., Cesca D., Casciani C. U. Assessment of the upper gastrointestinal tract in hemodialysis patients awaiting renal transplantation. Am J Gastroenterol. 1983 Jun;78(6):328–331. [PubMed] [Google Scholar]
  16. Mitchell C. J., Jewell D. P., Lewin M. R., McLaughlin J. E., Moorhead J. F. Gastric function and histology in chronic renal failure. J Clin Pathol. 1979 Mar;32(3):208–213. doi: 10.1136/jcp.32.3.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Morris A., Nicholson G., Lloyd G., Haines D., Rogers A., Taylor D. Seroepidemiology of Campylobacter pyloridis. N Z Med J. 1986 Sep 10;99(809):657–659. [PubMed] [Google Scholar]
  18. Musola R., Franzin G., Mora R., Manfrini C. Prevalence of gastroduodenal lesions in uremic patients undergoing dialysis and after renal transplantation. Gastrointest Endosc. 1984 Dec;30(6):343–346. doi: 10.1016/s0016-5107(84)72450-3. [DOI] [PubMed] [Google Scholar]
  19. Paimela H., Härkönen M., Karonen S. L., Tallgren L. G., Stenman S., Ahonen J. Relation between serum group II pepsinogen concentration and the degree of Brunner's gland hyperplasia in patients with chronic renal failure. Gut. 1985 Feb;26(2):198–202. doi: 10.1136/gut.26.2.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rathbone B. J., Wyatt J. I., Heatley R. V. Campylobacter pyloridis--a new factor in peptic ulcer disease? Gut. 1986 Jun;27(6):635–641. doi: 10.1136/gut.27.6.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Shousha S., Spiller R. C., Parkins R. A. The endoscopically abnormal duodenum in patients with dyspepsia: biopsy findings in 60 cases. Histopathology. 1983 Jan;7(1):23–34. doi: 10.1111/j.1365-2559.1983.tb02213.x. [DOI] [PubMed] [Google Scholar]
  22. Siurala M., Isokoski M., Varis K., Kekki M. Prevalence of gastritis in a rural population. Bioptic study of subjects selected at random. Scand J Gastroenterol. 1968;3(2):211–223. doi: 10.3109/00365526809180125. [DOI] [PubMed] [Google Scholar]
  23. Tani N., Harasawa S., Suzuki S., Miwa M., Sakita R., Nomiyama T., Watanabe H., Senoue I., Kikuchi K., Miwa T. Lesions of the upper gastrointestinal tract in patients with chronic renal failure. Gastroenterol Jpn. 1980;15(5):480–484. doi: 10.1007/BF02773912. [DOI] [PubMed] [Google Scholar]
  24. Varis K. Epidemiology of gastritis. Scand J Gastroenterol Suppl. 1982;79:44–51. [PubMed] [Google Scholar]
  25. Vaziri N. D., Dure-Smith B., Miller R., Mirahmadi M. K. Pathology of gastrointestinal tract in chronic hemodialysis patients: an autopsy study of 78 cases. Am J Gastroenterol. 1985 Aug;80(8):608–611. [PubMed] [Google Scholar]
  26. Villako K., Tamm A., Savisaar E., Ruttas M. Prevalence of antral and fundic gastritis in a randomly selected group of an Estonian rural population. Scand J Gastroenterol. 1976;11(8):817–822. [PubMed] [Google Scholar]
  27. Zukerman G. R., Mills B. A., Koehler R. E., Siegel A., Harter H. R., DeSchryver-Kecskemeti K. Nodular duodenitis. Pathologic and clinical characteristics in patients with end-stage renal disease. Dig Dis Sci. 1983 Nov;28(11):1018–1024. doi: 10.1007/BF01311731. [DOI] [PubMed] [Google Scholar]

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