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. 1990 Oct;31(10):1120–1125. doi: 10.1136/gut.31.10.1120

Experience with a gastrointestinal marker (51CrCl3) in a combined study of ileal function using 75SeHCAT and 58CoB12 measured by whole body counting.

T Smith 1, I Bjarnason 1
PMCID: PMC1378735  PMID: 2128070

Abstract

Introduction of a radioactive gastrointestinal marker (51CrCl3) into a combined study (75SeHCAT + 58CoB12) of ileal function by whole body counting has been undertaken. The technique was assessed in 23 subjects (15 patients with inflammatory bowel disease, six on non-steroidal anti-inflammatory drugs for rheumatoid arthritis, and two normal subjects). Mean (SD) 51CrCl3 retention was only 4.1 (6.0)% on day 4, and was similar on day 7 in subjects given a second dose of 51CrCl3 on day 4. Only one subject had more than 20% of 51CrCl3 retention after four days. A 51CrCl3 correction method adequately corrected for colonic hold up of 58CoB12, when compared with final equilibrium values of 58CoB12 retention. Use of the non-absorbed 58CoB12 fraction as a gastrointestinal marker gave good agreement with the 51CrCl3 method in correcting 75SeHCAT values. In all subjects studied, corrections for colonic retention of 75SeHCAT on day 4, were small (less than 7% of dose) and did not affect the assessment of any subject. In conclusion, an additional gastrointestinal marker such as 51CrCl3 is unnecessary in our combined study since that role can be effected, when indicated by the non-absorbed 58CoB12 fraction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bjarnason I., Peters T. J., Veall N. A persistent defect in intestinal permeability in coeliac disease demonstrated by a 51Cr-labelled EDTA absorption test. Lancet. 1983 Feb 12;1(8320):323–325. doi: 10.1016/s0140-6736(83)91628-8. [DOI] [PubMed] [Google Scholar]
  2. Bjarnason I., Zanelli G., Smith T., Prouse P., Williams P., Smethurst P., Delacey G., Gumpel M. J., Levi A. J. Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans. Gastroenterology. 1987 Sep;93(3):480–489. doi: 10.1016/0016-5085(87)90909-7. [DOI] [PubMed] [Google Scholar]
  3. Delhez H., van den Berg J. W., van Blankenstein M., Meerwaldt J. H. New method for the determination of bile acid turnover using 75Se-homocholic acid taurine. Eur J Nucl Med. 1982;7(6):269–271. doi: 10.1007/BF00251479. [DOI] [PubMed] [Google Scholar]
  4. Fagan E. A., Chadwick V. S., Baird I. M. SeHCAT absorption: a simple test of ileal dysfunction. Digestion. 1983;26(3):159–165. doi: 10.1159/000198883. [DOI] [PubMed] [Google Scholar]
  5. Ferraris R., Jazrawi R., Bridges C., Northfield T. C. Use of a gamma-labeled bile acid (75SeHCAT) as a test of ileal function. Methods of improving accuracy. Gastroenterology. 1986 May;90(5 Pt 1):1129–1136. doi: 10.1016/0016-5085(86)90377-x. [DOI] [PubMed] [Google Scholar]
  6. HANSKY J., CONNELL A. M. Measurement of gastrointestinal transit using radioactive chromium. Gut. 1962 Jun;3:187–188. doi: 10.1136/gut.3.2.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hames T. K., Condon B. R., Fleming J. S., Phillips G., Holdstock G., Smith C. L., Howlett P. J., Ackery D. A comparison between the use of a shadow shield whole body counter and an uncollimated gamma camera ain the assessment of the seven-day retention of SeHCAT. Br J Radiol. 1984 Jul;57(679):581–584. doi: 10.1259/0007-1285-57-679-581. [DOI] [PubMed] [Google Scholar]
  8. Ludgate S. M., Merrick M. V. The pathogenesis of post-irradiation chronic diarrhoea: measurement of SeHCAT and B12 absorption for differential diagnosis determines treatment. Clin Radiol. 1985 May;36(3):275–278. doi: 10.1016/s0009-9260(85)80059-3. [DOI] [PubMed] [Google Scholar]
  9. Merrick M. V., Eastwood M. A., Anderson J. R., Ross H. M. Enterohepatic circulation in man of a gamma-emitting bile-acid conjugate, 23-selena-25-homotaurocholic acid (SeHCAT). J Nucl Med. 1982 Feb;23(2):126–130. [PubMed] [Google Scholar]
  10. Merrick M. V., Eastwood M. A., Ford M. J. Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention. Br Med J (Clin Res Ed) 1985 Mar 2;290(6469):665–668. doi: 10.1136/bmj.290.6469.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nyhlin H., Merrick M. V., Eastwood M. A., Brydon W. G. Evaluation of ileal function using 23-selena-25-homotaurocholate, a-gamma-labeled conjugated bile acid. Initial clinical assessment. Gastroenterology. 1983 Jan;84(1):63–68. [PubMed] [Google Scholar]
  12. Schroth H. J., Berberich R., Feifel G., Müller K. P., Ecker K. W. Tests for the absorption of 75Se-labelled homocholic acid conjugated with taurine (75Se-HCAT). Eur J Nucl Med. 1985;10(9-10):455–457. doi: 10.1007/BF00256590. [DOI] [PubMed] [Google Scholar]
  13. Sciarretta G., Fagioli G., Furno A., Vicini G., Cecchetti L., Grigolo B., Verri A., Malaguti P. 75Se HCAT test in the detection of bile acid malabsorption in functional diarrhoea and its correlation with small bowel transit. Gut. 1987 Aug;28(8):970–975. doi: 10.1136/gut.28.8.970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Smith T., Bjarnason I., Hesp R. Critical analysis of the accuracy of a combined test (75Se-HCAT and 58Co-B12) of ileal function using a whole-body counter. Clin Phys Physiol Meas. 1987 May;8(2):159–171. doi: 10.1088/0143-0815/8/2/006. [DOI] [PubMed] [Google Scholar]
  15. Smith T., Hesp R., Mackenzie J. Total body potassium calibrations for normal and obese subjects in two types of whole body counter. Phys Med Biol. 1979 Jan;24(1):171–175. doi: 10.1088/0031-9155/24/1/016. [DOI] [PubMed] [Google Scholar]
  16. Thaysen E. H., Orholm M., Arnfred T., Carl J., Rødbro P. Assessment of ileal function by abdominal counting of the retention of a gamma emitting bile acid analogue. Gut. 1982 Oct;23(10):862–865. doi: 10.1136/gut.23.10.862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yeoh E. K., Lui D., Lee N. Y. The mechanism of diarrhoea resulting from pelvic and abdominal radiotherapy; a prospective study using selenium-75 labelled conjugated bile acid and cobalt-58 labelled cyanocobalamin. Br J Radiol. 1984 Dec;57(684):1131–1136. doi: 10.1259/0007-1285-57-684-1131. [DOI] [PubMed] [Google Scholar]

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