Abstract
Studies were carried out in 36 adult male rats to determine the characteristics of lipid substances which, after infusion into the ileum, slow the stomach to caecum transit time of the head of a bean meal in the rat. Stomach to caecum transit time was measured by environmental hydrogen analysis. Ileal infusion of a range of free fatty acids including petroselinic, oleic, myristoleic, erucic, linoleic, and linolenic all significantly slowed stomach to caecum transit time, as did the detergents (sodium bis (2-ethyl hexyl) sulphosuccinate and sodium linoleyl sulphate), the triglyceride corn oil, and the phospholipid lecithin. Although the lipid soluble deconjugated bile acid deoxycholic acid slowed stomach to caecum transit time, the water soluble conjugated bile acid taurocholic acid accelerated it. Infusion of the lipid alcohol oleyl alcohol and the calcium chelating agent disodium edetate (EDTA) into the ileum did not delay the passage of the meal through the stomach and small intestine. The diversity of lipid substances activating the ileal brake suggest a nonspecific effect by lipid soluble substances that can penetrate cell membranes. The lack of effect of EDTA suggested that calcium binding was not important.
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- Barker G. R., Cochrane G. M., Corbett G. A., Dufton J. F., Hunt J. N., Roberts S. K. Glucose, glycine and diglycine in test meals at stimuli to a duodenal osmoreceptor slowing gastric emptying. J Physiol. 1978 Oct;283:341–346. doi: 10.1113/jphysiol.1978.sp012504. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bond J. H., Jr, Levitt M. D., Prentiss R. Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med. 1975 Apr;85(4):546–555. [PubMed] [Google Scholar]
- Brown N. J., Rumsey R. D., Read N. W. Adaptation of hydrogen analysis to measure stomach to caecum transit time in the rat. Gut. 1987 Jul;28(7):849–854. doi: 10.1136/gut.28.7.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cotterell D., Kohn P. G. Variation in tissue resistance in rat small intestine: its relationship to observed potential changes. Biochim Biophys Acta. 1970 Mar 17;203(1):179–181. doi: 10.1016/0005-2736(70)90050-7. [DOI] [PubMed] [Google Scholar]
- Fordtran J. S., Rector F. C., Jr, Ewton M. F., Soter N., Kinney J. Permeability characteristics of the human small intestine. J Clin Invest. 1965 Dec;44(12):1935–1944. doi: 10.1172/JCI105299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Penagini R., Misiewicz J. J., Frost P. G. Effect of jejunal infusion of bile acids on small bowel transit and fasting jejunal motility in man. Gut. 1988 Jun;29(6):789–794. doi: 10.1136/gut.29.6.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Read N. W., McFarlane A., Kinsman R. I., Bates T. E., Blackhall N. W., Farrar G. B., Hall J. C., Moss G., Morris A. P., O'Neill B. Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology. 1984 Feb;86(2):274–280. [PubMed] [Google Scholar]
- Read N. W., Miles C. A., Fisher D., Holgate A. M., Kime N. D., Mitchell M. A., Reeve A. M., Roche T. B., Walker M. Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea. Gastroenterology. 1980 Dec;79(6):1276–1282. [PubMed] [Google Scholar]
- Spiller R. C., Trotman I. F., Higgins B. E., Ghatei M. A., Grimble G. K., Lee Y. C., Bloom S. R., Misiewicz J. J., Silk D. B. The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man. Gut. 1984 Apr;25(4):365–374. doi: 10.1136/gut.25.4.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Welch I. M., Cunningham K. M., Read N. W. Regulation of gastric emptying by ileal nutrients in humans. Gastroenterology. 1988 Feb;94(2):401–404. doi: 10.1016/0016-5085(88)90428-3. [DOI] [PubMed] [Google Scholar]