Abstract
We have previously shown that infusion of triglycerides and long chain fatty acids into the ileum of humans and rats delays small bowel transit time. The present studies have investigated the effect on the stomach to caecum transit time of a baked bean meal of the ileal infusion of 20 mM, 50 mM, and 100 mM acetic, butyric, hexenoic, and caprylic acids in rats. After an 18 hour fast either a control or a short chain fatty acid (SCFA) solution (pH 6.5) was infused into the ileum for 30 minutes (0.3 ml/hour). A test meal was given by gavage and the infusion continued for a further 150 minutes. The arrival of the meal in the colon was signalled by a rise in the exhaled hydrogen concentration. Acetic acid (20 mM, 50 mM, 100 mM), butyric acid (100 mM), and caprylic acid (100 mM) produced a significant acceleration of transit which was inversely proportional to SCFA chain length. In a separate experiment, infusion of 100 mM acetic acid, the most potent SCFA, into an isolated ileal Thirty-Vella loop failed to accelerate transit of the test meal. Our results suggest that SCFAs accelerate transit via a local enteric reflex.
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Selected References
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- Brown N. J., Rumsey R. D., Read N. W. Adaptation of hydrogen analysis to measure stomach to caecum transit time in the rat. Gut. 1987 Jul;28(7):849–854. doi: 10.1136/gut.28.7.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dent J., Dodds W. J., Friedman R. H., Sekiguchi T., Hogan W. J., Arndorfer R. C., Petrie D. J. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest. 1980 Feb;65(2):256–267. doi: 10.1172/JCI109667. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holgate A. M., Read N. W. Effect of ileal infusion of intralipid on gastrointestinal transit, ileal flow rate, and carbohydrate absorption in humans after ingestion of a liquid meal. Gastroenterology. 1985 Apr;88(4):1005–1011. doi: 10.1016/s0016-5085(85)80021-4. [DOI] [PubMed] [Google Scholar]
- Kamath P. S., Hoepfner M. T., Phillips S. F. Short-chain fatty acids stimulate motility of the canine ileum. Am J Physiol. 1987 Oct;253(4 Pt 1):G427–G433. doi: 10.1152/ajpgi.1987.253.4.G427. [DOI] [PubMed] [Google Scholar]
- Kamath P. S., Phillips S. F. Initiation of motility in canine ileum by short chain fatty acids and inhibition by pharmacological agents. Gut. 1988 Jul;29(7):941–948. doi: 10.1136/gut.29.7.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kamath P. S., Phillips S. F., Zinsmeister A. R. Short-chain fatty acids stimulate ileal motility in humans. Gastroenterology. 1988 Dec;95(6):1496–1502. doi: 10.1016/s0016-5085(88)80068-4. [DOI] [PubMed] [Google Scholar]
- Kruis W., Azpiroz F., Phillips S. F. Contractile patterns and transit of fluid in canine terminal ileum. Am J Physiol. 1985 Aug;249(2 Pt 1):G264–G270. doi: 10.1152/ajpgi.1985.249.2.G264. [DOI] [PubMed] [Google Scholar]
- Miller T. L., Wolin M. J. Fermentations by saccharolytic intestinal bacteria. Am J Clin Nutr. 1979 Jan;32(1):164–172. doi: 10.1093/ajcn/32.1.164. [DOI] [PubMed] [Google Scholar]
- Read N. W., McFarlane A., Kinsman R. I., Bates T. E., Blackhall N. W., Farrar G. B., Hall J. C., Moss G., Morris A. P., O'Neill B. Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology. 1984 Feb;86(2):274–280. [PubMed] [Google Scholar]
- Remesy C., Demigne C. Partition and absorption of valatile fatty acids in the alimentary canal of the rat. Ann Rech Vet. 1976;7(1):39–55. [PubMed] [Google Scholar]
- Welch I. M., Cunningham K. M., Read N. W. Regulation of gastric emptying by ileal nutrients in humans. Gastroenterology. 1988 Feb;94(2):401–404. doi: 10.1016/0016-5085(88)90428-3. [DOI] [PubMed] [Google Scholar]