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. 1991 Sep;32(9):977–982. doi: 10.1136/gut.32.9.977

Weekend treatment with 20 and 40 mg omeprazole: effect on intragastric pH, fasting and postprandial serum gastrin, and serum pepsinogens.

L C Baak 1, J B Jansen 1, I Biemond 1, C B Lamers 1
PMCID: PMC1379032  PMID: 1916501

Abstract

Weekend treatment with 20 mg omeprazole reduces ulcer relapse rates but the results may improve with a higher dose regimen. We have evaluated three day weekend treatment with 20 and 40 mg doses of omeprazole in eight healthy subjects in a double blind crossover study. Twenty four hour ambulatory intragastric pH and basal and meal stimulated serum gastrin and serum pepsinogens A and C values were studied. The investigations began on the Friday before the third weekend course of omeprazole and were repeated on alternate days, except Sundays, for two weeks. When compared with values before the study, median 24 hour intragastric pH and basal and meal stimulated gastrin concentrations were significantly (p less than 0.01-0.05), but transiently, raised with both doses of omeprazole. Basal pepsinogen A and C values were significantly (p less than 0.01) increased on all study days, but did not return to their pre-study values before the next weekend dose, except for pepsinogen C in subjects treated with 20 mg omeprazole. A dose dependent effect was found for all parameters studied (p less than 0.05). In conclusion, weekend treatment with 20 and 40 mg omeprazole produces pronounced and dose dependent increases in intragastric pH, basal and meal stimulated serum gastrin, and basal serum pepsinogen A and C without inducing prolonged hypoacidity or hypergastrinaemia. Weekend treatment with 40 mg omeprazole merits further study in the prevention of peptic ulcer relapse.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baak L. C., Jansen J. B., Lamers C. B. Effect of intravenous omeprazole on intragastric pH during intravenous infusion of amino acids. Dig Dis Sci. 1990 May;35(5):596–602. doi: 10.1007/BF01540407. [DOI] [PubMed] [Google Scholar]
  2. Biemond I., Crobach L. F., Jansen J. B., Lamers C. B. Effect of short-term omeprazole administration on serum pepsinogens in relation to fasting serum gastrin and gastric acid secretion. Eur J Clin Pharmacol. 1989;37(4):345–349. doi: 10.1007/BF00558498. [DOI] [PubMed] [Google Scholar]
  3. Biemond I., Jansen J. B., Crobach L. F., Kreuning J., Lamers C. B. Radioimmunoassay of human pepsinogen A and pepsinogen C. J Clin Chem Clin Biochem. 1989 Jan;27(1):19–25. doi: 10.1515/cclm.1989.27.1.19. [DOI] [PubMed] [Google Scholar]
  4. Cederberg C., Ekenved G., Lind T., Olbe L. Acid inhibitory characteristics of omeprazole in man. Scand J Gastroenterol Suppl. 1985;108:105–112. doi: 10.3109/00365528509095823. [DOI] [PubMed] [Google Scholar]
  5. Crobach L. F., Jansen J. B., Lamers C. B. Effect of intermittent weekend therapy with omeprazole on basal and bombesin- and pentagastrin-stimulated gastric acid and serum gastrin. Scand J Gastroenterol. 1988 May;23(4):407–412. doi: 10.3109/00365528809093887. [DOI] [PubMed] [Google Scholar]
  6. Crobach L. F., Jansen J. B., Lamers C. B. Effect of intermittent weekend therapy with omeprazole on basal and postprandial serum gastrin concentrations in patients with duodenal ulcer. Clin Pharmacol Ther. 1988 Jun;43(6):643–647. doi: 10.1038/clpt.1988.89. [DOI] [PubMed] [Google Scholar]
  7. Fellenius E., Berglindh T., Sachs G., Olbe L., Elander B., Sjöstrand S. E., Wallmark B. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase. Nature. 1981 Mar 12;290(5802):159–161. doi: 10.1038/290159a0. [DOI] [PubMed] [Google Scholar]
  8. Festen H. P., Thijs J. C., Lamers C. B., Jansen J. M., Pals G., Frants R. R., Défize J., Meuwissen S. G. Effect of oral omeprazole on serum gastrin and serum pepsinogen I levels. Gastroenterology. 1984 Nov;87(5):1030–1034. [PubMed] [Google Scholar]
  9. Festen H. P., Tuynman H. A., Défize J., Pals G., Frants R. R., Straub J. P., Meuwissen S. G. Effect of single and repeated doses of oral omeprazole on gastric acid and pepsin secretion and fasting serum gastrin and serum pepsinogen I levels. Dig Dis Sci. 1986 Jun;31(6):561–566. doi: 10.1007/BF01318685. [DOI] [PubMed] [Google Scholar]
  10. Fimmel C. J., Etienne A., Cilluffo T., von Ritter C., Gasser T., Rey J. P., Caradonna-Moscatelli P., Sabbatini F., Pace F., Bühler H. W. Long-term ambulatory gastric pH monitoring: validation of a new method and effect of H2-antagonists. Gastroenterology. 1985 Jun;88(6):1842–1851. doi: 10.1016/0016-5085(85)90009-5. [DOI] [PubMed] [Google Scholar]
  11. Hewson E. G., Yeomans N. D., Angus P. W., Shulkes A., Brook C. W., Sewell R. B., Smallwood R. A. Effect of 'weekend therapy' with omeprazole on basal and stimulated acid secretion and fasting plasma gastrin in duodenal ulcer patients. Gut. 1988 Dec;29(12):1715–1720. doi: 10.1136/gut.29.12.1715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Howden C. W., Forrest J. A., Reid J. L. Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man. Gut. 1984 Jul;25(7):707–710. doi: 10.1136/gut.25.7.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jansen J. B., Lamers C. B. Omeprazole in the short-term treatment of reflux oesophagitis. Digestion. 1989;44 (Suppl 1):40–46. doi: 10.1159/000200103. [DOI] [PubMed] [Google Scholar]
  14. Klinkenberg-Knol E. C., Meuwissen S. G. Treatment of reflux oesophagitis resistant to H2-receptor antagonists. Digestion. 1989;44 (Suppl 1):47–53. doi: 10.1159/000200216. [DOI] [PubMed] [Google Scholar]
  15. Lambers C. B., Lind T., Moberg S., Jansen J. B., Olbe L. Omeprazole in Zollinger-Ellison syndrome. Effects of a single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonists. N Engl J Med. 1984 Mar 22;310(12):758–761. doi: 10.1056/NEJM198403223101205. [DOI] [PubMed] [Google Scholar]
  16. Lamberts R., Creutzfeldt W., Stöckmann F., Jacubaschke U., Maas S., Brunner G. Long-term omeprazole treatment in man: effects on gastric endocrine cell populations. Digestion. 1988;39(2):126–135. doi: 10.1159/000199615. [DOI] [PubMed] [Google Scholar]
  17. Lanzon-Miller S., Pounder R. E., Hamilton M. R., Ball S., Chronos N. A., Raymond F., Olausson M., Cederberg C. Twenty-four-hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine or omeprazole. Aliment Pharmacol Ther. 1987 Jun;1(3):239–251. doi: 10.1111/j.1365-2036.1987.tb00623.x. [DOI] [PubMed] [Google Scholar]
  18. Lind T., Cederberg C., Ekenved G., Haglund U., Olbe L. Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man. Gut. 1983 Apr;24(4):270–276. doi: 10.1136/gut.24.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lind T., Cederberg C., Forssell H., Olausson M., Olbe L. Relationship between reduction of gastric acid secretion and plasma gastrin concentration during omeprazole treatment. Scand J Gastroenterol. 1988 Dec;23(10):1259–1266. doi: 10.3109/00365528809090202. [DOI] [PubMed] [Google Scholar]
  20. Londong W., Londong V., Cederberg C., Steffen H. Dose-response study of omeprazole on meal-stimulated gastric acid secretion and gastrin release. Gastroenterology. 1983 Dec;85(6):1373–1378. [PubMed] [Google Scholar]
  21. Meijer J. L., Jansen J. B., Lamers C. B. Omeprazole in the treatment of Zollinger-Ellison syndrome and histamine H2-antagonist refractory ulcers. Digestion. 1989;44 (Suppl 1):31–39. doi: 10.1159/000200102. [DOI] [PubMed] [Google Scholar]
  22. Merki H. S., Witzel L., Walt R. P., Cohnen E., Harre K., Heim J., Mappes A., Röhmel J. Day-to-day variation of 24-hour intragastric acidity. Gastroenterology. 1988 Apr;94(4):887–891. doi: 10.1016/0016-5085(88)90543-4. [DOI] [PubMed] [Google Scholar]
  23. Müller P., Dammann H. G., Seitz H., Simon B. Effect of repeated, once daily, oral omeprazole on gastric secretion. Lancet. 1983 Jan 1;1(8314-5):66–66. doi: 10.1016/s0140-6736(83)91596-9. [DOI] [PubMed] [Google Scholar]
  24. Sharma B. K., Walt R. P., Pounder R. E., Gomes M. D., Wood E. C., Logan L. H. Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity. Gut. 1984 Sep;25(9):957–964. doi: 10.1136/gut.25.9.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Simoens C., Woussen-Colle M. C., De Graef J. Effect of cimetidine, ranitidine and omeprazole on postprandial gastrin and somatostatin release in conscious dogs. Regul Pept. 1988 Aug;22(3):285–293. doi: 10.1016/0167-0115(88)90041-9. [DOI] [PubMed] [Google Scholar]
  26. Ten Kate R. W., Tuynman H. A., Festen H. P., Pals G., Meuwissen S. G. Effect of high dose omeprazole on gastric pepsin secretion and serum pepsinogen levels in man. Eur J Clin Pharmacol. 1988;35(2):173–176. doi: 10.1007/BF00609248. [DOI] [PubMed] [Google Scholar]
  27. Walan A., Bader J. P., Classen M., Lamers C. B., Piper D. W., Rutgersson K., Eriksson S. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med. 1989 Jan 12;320(2):69–75. doi: 10.1056/NEJM198901123200201. [DOI] [PubMed] [Google Scholar]
  28. de Bruijne J. W., Snel P., Lamers C. B. Efficacy of the H+/K+-adenosine triphosphatase inhibitor omeprazole in peptic ulcer. Digestion. 1989;44 (Suppl 1):25–30. doi: 10.1159/000200101. [DOI] [PubMed] [Google Scholar]
  29. ten Kate R. W., Pals G., Pronk J. C., Bank R. A., Eriksson A. W., Donker A. J., Meuwissen S. G. Renal handling of pepsinogens A and C in man. Clin Sci (Lond) 1988 Dec;75(6):649–654. doi: 10.1042/cs0750649. [DOI] [PubMed] [Google Scholar]

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