Skip to main content
PMC home page
Gut logoLink to Gut
. 1991 Sep;32(9):1084–1086. doi: 10.1136/gut.32.9.1084

Androgen associated hepatocellular carcinoma with an aggressive course.

D Gleeson 1, M J Newbould 1, P Taylor 1, R F McMahon 1, B C Leahy 1, T W Warnes 1
PMCID: PMC1379057  PMID: 1655591

Abstract

The hepatocellular carcinomas that develop in patients treated with androgens have previously been associated with a benign clinical outcome. We describe a man who developed a hepatocellular carcinoma after 24 years of androgen treatment, whose tumour initially showed partial regression after withdrawal of androgens but subsequently pursued an aggressive and fatal course.

Full text

PDF
1084

Images in this article

1085Figure 1
on p.1085
1086Figure 2
on p.1086

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernstein M. S., Hunter R. L., Yachnin S. Hepatoma and peliosis hepatis developing in a patient with Fanconi's anemia. N Engl J Med. 1971 May 20;284(20):1135–1136. doi: 10.1056/NEJM197105202842006. [DOI] [PubMed] [Google Scholar]
  2. Bruix J., Barrera J. M., Calvet X., Ercilla G., Costa J., Sanchez-Tapias J. M., Ventura M., Vall M., Bruguera M., Bru C. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet. 1989 Oct 28;2(8670):1004–1006. doi: 10.1016/s0140-6736(89)91015-5. [DOI] [PubMed] [Google Scholar]
  3. Colombo M., Kuo G., Choo Q. L., Donato M. F., Del Ninno E., Tommasini M. A., Dioguardi N., Houghton M. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet. 1989 Oct 28;2(8670):1006–1008. doi: 10.1016/s0140-6736(89)91016-7. [DOI] [PubMed] [Google Scholar]
  4. Creagh T. M., Rubin A., Evans D. J. Hepatic tumours induced by anabolic steroids in an athlete. J Clin Pathol. 1988 Apr;41(4):441–443. doi: 10.1136/jcp.41.4.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Farrell G. C., Joshua D. E., Uren R. F., Baird P. J., Perkins K. W., Kronenberg H. Androgen-induced hepatoma. Lancet. 1975 Feb 22;1(7904):430–432. doi: 10.1016/s0140-6736(75)91494-4. [DOI] [PubMed] [Google Scholar]
  6. Goodman M. A., Laden A. M. Hepatocellular carcinoma in association with androgen therapy. Med J Aust. 1977 Feb 12;1(7):220–221. doi: 10.5694/j.1326-5377.1977.tb130636.x. [DOI] [PubMed] [Google Scholar]
  7. Hayward R. D., O'Reilly G. V. Intracerebral haemorrhage. Accuracy of computerised transverse axial scanning in predicting the underlying aetiology. Lancet. 1976 Jan 3;1(7949):1–4. doi: 10.1016/s0140-6736(76)92904-4. [DOI] [PubMed] [Google Scholar]
  8. Henderson J. T., Richmond J., Sumerling M. D. Androgenic-anabolic steroid therapy and hepatocellular carcinoma. Lancet. 1973 Apr 28;1(7809):934–934. doi: 10.1016/s0140-6736(73)91384-6. [DOI] [PubMed] [Google Scholar]
  9. Hernandez-Nieto L., Bruguera M., Bombi J., Camacho L., Rozman C. Benign liver-cell adenoma associated with long-term administration of an androgenic-anabolic steroid (methandienone). Cancer. 1977 Oct;40(4):1761–1764. doi: 10.1002/1097-0142(197710)40:4<1761::aid-cncr2820400454>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  10. Johnson F. L., Lerner K. G., Siegel M., Feagler J. R., Majerus P. W., Hartmann J. R., Thomas E. D. Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet. 1972 Dec 16;2(7790):1273–1276. doi: 10.1016/s0140-6736(72)92649-9. [DOI] [PubMed] [Google Scholar]
  11. Kew M. C., Houghton M., Choo Q. L., Kuo G. Hepatitis C virus antibodies in southern African blacks with hepatocellular carcinoma. Lancet. 1990 Apr 14;335(8694):873–874. doi: 10.1016/0140-6736(90)90474-j. [DOI] [PubMed] [Google Scholar]
  12. Kew M. C., Van Coller B., Prowse C. M., Skikne B., Wolfsdorf J. I., Isdale J., Krawitz S., Altman H., Levin S. E., Bothwell T. H. Occurrence of primary hepatocellular cancer and peliosis hepatis after treatment with androgenic steroids. S Afr Med J. 1976 Jul 24;50(32):1233–1237. [PubMed] [Google Scholar]
  13. Kuo G., Choo Q. L., Alter H. J., Gitnick G. L., Redeker A. G., Purcell R. H., Miyamura T., Dienstag J. L., Alter M. J., Stevens C. E. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989 Apr 21;244(4902):362–364. doi: 10.1126/science.2496467. [DOI] [PubMed] [Google Scholar]
  14. McCaughan G. W., Bilous M. J., Gallagher N. D. Long-term survival with tumor regression in androgen-induced liver tumors. Cancer. 1985 Dec 1;56(11):2622–2626. doi: 10.1002/1097-0142(19851201)56:11<2622::aid-cncr2820561115>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  15. Meadows A. T., Naiman J. L., Valdes-Dapena M. Hepatoma associated with androgen therapy for aplastic anemia. J Pediatr. 1974 Jan;84(1):109–110. doi: 10.1016/s0022-3476(74)80565-2. [DOI] [PubMed] [Google Scholar]
  16. Overly W. L., Dankoff J. A., Wang B. K., Singh U. D. Androgens and hepatocellular carcinoma in an athlete. Ann Intern Med. 1984 Jan;100(1):158–159. doi: 10.7326/0003-4819-100-1-158_3. [DOI] [PubMed] [Google Scholar]
  17. Sale G. E., Lerner K. G. Multiple tumors after androgen therapy. Arch Pathol Lab Med. 1977 Nov;101(11):600–603. [PubMed] [Google Scholar]
  18. Westaby D., Portmann B., Williams R. Androgen related primary hepatic tumors in non-Fanconi patients. Cancer. 1983 May 15;51(10):1947–1952. doi: 10.1002/1097-0142(19830515)51:10<1947::aid-cncr2820511034>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES