Skip to main content
NCBI home page
Gut logoLink to Gut
. 1991 Nov;32(11):1412–1414. doi: 10.1136/gut.32.11.1412

Increase in gamma/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease.

M Mäki 1, K Holm 1, P Collin 1, E Savilahti 1
PMCID: PMC1379179  PMID: 1836446

Abstract

A jejunal biopsy specimen from an asymptomatic 35 year old man was studied because of a low serum titre of reticulin antibody and the finding of coeliac disease in his son. In this specimen villous structure was quite normal as was the total number of intraepithelial lymphocytes, but the number of gamma/delta T cell receptor bearing lymphocytes was 10 times higher than the mean in control subjects. Two years later a further biopsy specimen was obtained because of clinical symptoms and an increased titre of reticulin antibody. This specimen showed villous atrophy with crypt hyperplasia and increased infiltration of intraepithelial lymphocytes compatible with coeliac disease. A control biopsy specimen taken during gluten free diet showed normalisation of the villous architecture. Latent coeliac disease may be characterised by an increase in gamma/delta positive cells similar to that seen in established coeliac disease.

Full text

PDF
1412

Images in this article

1413p1413-a
on p.1413

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brandtzaeg P., Bosnes V., Halstensen T. S., Scott H., Sollid L. M., Valnes K. N. T lymphocytes in human gut epithelium preferentially express the alpha/beta antigen receptor and are often CD45/UCHL1-positive. Scand J Immunol. 1989 Jul;30(1):123–128. doi: 10.1111/j.1365-3083.1989.tb01196.x. [DOI] [PubMed] [Google Scholar]
  2. Bucy R. P., Chen C. L., Cooper M. D. Tissue localization and CD8 accessory molecule expression of T gamma delta cells in humans. J Immunol. 1989 May 1;142(9):3045–3049. [PubMed] [Google Scholar]
  3. Chorzelski T. P., Rosinska D., Beutner E. H., Sulej J., Kumar V. Aggressive gluten challenge of dermatitis herpetiformis cases converts them from seronegative to seropositive for IgA-class endomysial antibodies. J Am Acad Dermatol. 1988 Apr;18(4 Pt 1):672–678. doi: 10.1016/s0190-9622(88)70089-4. [DOI] [PubMed] [Google Scholar]
  4. Collin P., Hällström O., Mäki M., Viander M., Keyriläinen O. Atypical coeliac disease found with serologic screening. Scand J Gastroenterol. 1990 Mar;25(3):245–250. [PubMed] [Google Scholar]
  5. Doherty M., Barry R. E. Gluten-induced mucosal changes in subjects without overt small-bowel disease. Lancet. 1981 Mar 7;1(8219):517–520. doi: 10.1016/s0140-6736(81)92860-9. [DOI] [PubMed] [Google Scholar]
  6. Egan-Mitchell B., Fottrell P. F., McNicholl B. Early or pre-coeliac mucosa: development of gluten enteropathy. Gut. 1981 Jan;22(1):65–69. doi: 10.1136/gut.22.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ferguson A., Blackwell J. N., Barnetson R. S. Effects of additional dietary gluten on the small-intestinal mucosa of volunteers and of patients with dermatitis herpetiformis. Scand J Gastroenterol. 1987 Jun;22(5):543–549. doi: 10.3109/00365528708991895. [DOI] [PubMed] [Google Scholar]
  8. Freeman H. J., Chiu B. K. Multifocal small bowel lymphoma and latent celiac sprue. Gastroenterology. 1986 Jun;90(6):1992–1997. doi: 10.1016/0016-5085(86)90272-6. [DOI] [PubMed] [Google Scholar]
  9. Groh V., Porcelli S., Fabbi M., Lanier L. L., Picker L. J., Anderson T., Warnke R. A., Bhan A. K., Strominger J. L., Brenner M. B. Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med. 1989 Apr 1;169(4):1277–1294. doi: 10.1084/jem.169.4.1277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Halstensen T. S., Scott H., Brandtzaeg P. Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease. Scand J Immunol. 1989 Dec;30(6):665–672. doi: 10.1111/j.1365-3083.1989.tb02474.x. [DOI] [PubMed] [Google Scholar]
  11. Holmes G. K., Prior P., Lane M. R., Pope D., Allan R. N. Malignancy in coeliac disease--effect of a gluten free diet. Gut. 1989 Mar;30(3):333–338. doi: 10.1136/gut.30.3.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Logan R. F., Tucker G., Rifkind E. A., Heading R. C., Ferguson A. Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960-79. Br Med J (Clin Res Ed) 1983 Jan 8;286(6359):95–97. doi: 10.1136/bmj.286.6359.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marsh M. N., Bjarnason I., Shaw J., Ellis A., Baker R., Peters T. J. Studies of intestinal lymphoid tissue. XIV--HLA status, mucosal morphology, permeability and epithelial lymphocyte populations in first degree relatives of patients with coeliac disease. Gut. 1990 Jan;31(1):32–36. doi: 10.1136/gut.31.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McConnell R. B., Whitwell F. Letter: Small-intestinal histology in coeliac disease. Lancet. 1975 Aug 30;2(7931):418–418. doi: 10.1016/s0140-6736(75)92943-8. [DOI] [PubMed] [Google Scholar]
  15. Mäki M., Holm K. Incidence and prevalence of coeliac disease in Tampere. Coeliac disease is not disappearing. Acta Paediatr Scand. 1990 Oct;79(10):980–982. doi: 10.1111/j.1651-2227.1990.tb11367.x. [DOI] [PubMed] [Google Scholar]
  16. Mäki M., Holm K., Koskimies S., Hällström O., Visakorpi J. K. Normal small bowel biopsy followed by coeliac disease. Arch Dis Child. 1990 Oct;65(10):1137–1141. doi: 10.1136/adc.65.10.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. O'Mahony S., Vestey J. P., Ferguson A. Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. Lancet. 1990 Jun 23;335(8704):1487–1490. doi: 10.1016/0140-6736(90)93029-o. [DOI] [PubMed] [Google Scholar]
  18. Salazar de Sousa J., Ramos de Almeida J. M., Monteiro M. V., Magalhäes Ramalho P. Late onset coeliac disease in the monozygotic twin of a coeliac child. Acta Paediatr Scand. 1987 Jan;76(1):172–174. doi: 10.1111/j.1651-2227.1987.tb10442.x. [DOI] [PubMed] [Google Scholar]
  19. Savilahti E., Arato A., Verkasalo M. Intestinal gamma/delta receptor-bearing T lymphocytes in celiac disease and inflammatory bowel diseases in children. Constant increase in celiac disease. Pediatr Res. 1990 Dec;28(6):579–581. doi: 10.1203/00006450-199012000-00005. [DOI] [PubMed] [Google Scholar]
  20. Spencer J., Isaacson P. G., Diss T. C., MacDonald T. T. Expression of disulfide-linked and non-disulfide-linked forms of the T cell receptor gamma/delta heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol. 1989 Jul;19(7):1335–1338. doi: 10.1002/eji.1830190728. [DOI] [PubMed] [Google Scholar]
  21. Stevens F. M., Egan-Mitchell B., Cryan E., McCarthy C. F., McNicholl B. Decreasing incidence of coeliac disease. Arch Dis Child. 1987 May;62(5):465–468. doi: 10.1136/adc.62.5.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Viney J., MacDonald T. T., Spencer J. Gamma/delta T cells in the gut epithelium. Gut. 1990 Aug;31(8):841–844. doi: 10.1136/gut.31.8.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Weinstein W. M. Latent celiac sprue. Gastroenterology. 1974 Apr;66(4):489–493. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES