Skip to main content
NCBI home page
Gut logoLink to Gut
. 1991 Dec;32(12):1470–1472. doi: 10.1136/gut.32.12.1470

Increased intestinal permeability in ankylosing spondylitis--primary lesion or drug effect?

A J Morris 1, C W Howden 1, C Robertson 1, A Duncan 1, H Torley 1, R D Sturrock 1, R I Russell 1
PMCID: PMC1379244  PMID: 1773950

Abstract

We have found increased small intestinal permeability to 51Cr-ethylenediaminetetra acetate in patients with ankylosing spondylitis compared with controls. There is no significant difference between patients with ankylosing spondylitis and patients with rheumatoid arthritis taking non-steroidal anti-inflammatory drugs (NSAID). The increased intestinal permeability in ankylosing spondylitis is independent of disease activity. These findings suggest that the increased permeability is caused by NSAID treatment and is probably not a primary lesion of small bowel mucosa.

Full text

PDF
1470

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bjarnason I., O'Morain C., Levi A. J., Peters T. J. Absorption of 51chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease. Gastroenterology. 1983 Aug;85(2):318–322. [PubMed] [Google Scholar]
  2. Bjarnason I., Peters T. J., Veall N. A persistent defect in intestinal permeability in coeliac disease demonstrated by a 51Cr-labelled EDTA absorption test. Lancet. 1983 Feb 12;1(8320):323–325. doi: 10.1016/s0140-6736(83)91628-8. [DOI] [PubMed] [Google Scholar]
  3. Bjarnason I., Peters T. J., Wise R. J. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet. 1984 Jan 28;1(8370):179–182. doi: 10.1016/s0140-6736(84)92109-3. [DOI] [PubMed] [Google Scholar]
  4. Bjarnason I., Williams P., So A., Zanelli G. D., Levi A. J., Gumpel J. M., Peters T. J., Ansell B. Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs. Lancet. 1984 Nov 24;2(8413):1171–1174. doi: 10.1016/s0140-6736(84)92739-9. [DOI] [PubMed] [Google Scholar]
  5. Cooper R., Fraser S. M., Sturrock R. D., Gemmell C. G. Raised titres of anti-klebsiella IgA in ankylosing spondylitis, rheumatoid arthritis, and inflammatory bowel disease. Br Med J (Clin Res Ed) 1988 May 21;296(6634):1432–1434. doi: 10.1136/bmj.296.6634.1432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. De Vos M., Cuvelier C., Mielants H., Veys E., Barbier F., Elewaut A. Ileocolonoscopy in seronegative spondylarthropathy. Gastroenterology. 1989 Feb;96(2 Pt 1):339–344. doi: 10.1016/0016-5085(89)91557-6. [DOI] [PubMed] [Google Scholar]
  7. Eastmond C. J., Calguner M., Shinebaum R., Cooke E. M., Wright V. A sequential study of the relationship between faecal Klebsiella aerogenes and the common clinical manifestations of ankylosing spondylitis. Ann Rheum Dis. 1982 Feb;41(1):15–20. doi: 10.1136/ard.41.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Laker M. F. Estimation of disaccharides in plasma and urine by gas-liquid chromatography. J Chromatogr. 1979 May 1;163(1):9–18. doi: 10.1016/s0378-4347(00)81163-9. [DOI] [PubMed] [Google Scholar]
  9. Laker M. F., Mount J. N. Mannitol estimation in biological fluids by gas-liquid chromatography of trimethylsilyl derivatives. Clin Chem. 1980 Mar;26(3):441–443. [PubMed] [Google Scholar]
  10. Maxton D. G., Bjarnason I., Reynolds A. P., Catt S. D., Peters T. J., Menzies I. S. Lactulose, 51Cr-labelled ethylenediaminetetra-acetate, L-rhamnose and polyethyleneglycol 400 [corrected] as probe markers for assessment in vivo of human intestinal permeability. Clin Sci (Lond) 1986 Jul;71(1):71–80. doi: 10.1042/cs0710071. [DOI] [PubMed] [Google Scholar]
  11. Smith M. D., Gibson R. A., Brooks P. M. Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. J Rheumatol. 1985 Apr;12(2):299–305. [PubMed] [Google Scholar]
  12. Wendling D., Bidet A., Guidet M. Intestinal permeability in ankylosing spondylitis. J Rheumatol. 1990 Jan;17(1):114–115. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES