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. 1992 Jul;33(7):882–886. doi: 10.1136/gut.33.7.882

Immunosenescence and mucosal immunity: significant effects of old age on secretory IgA concentrations and intraepithelial lymphocyte counts.

E Arranz 1, S O'Mahony 1, J R Barton 1, A Ferguson 1
PMCID: PMC1379398  PMID: 1644326

Abstract

Concentrations of immunoglobulins (Ig) and levels of isotype specific antibodies to three dietary antigens in serum, pure parotid saliva, and in intestinal secretions obtained by whole gut lavage from groups of healthy elderly subjects (aged greater than 70 years) and of younger adult controls (aged 25-50 years) were measured. In addition, counts of lamina propria and intra-epithelial lymphoid cells were performed in histologically normal jejunal biopsy specimens from elderly and younger subjects. Elderly subjects had significantly higher concentrations of serum and salivary IgA and of salivary IgM (both, p less than 0.01), and of salivary IgA antibodies than did the younger subjects, but the amount of immunoglobulin and antibody in whole gut lavage fluid was similar in the two age groups. Jejunal biopsy specimen cell counts showed higher IgA plasma cell counts and lower intraepithelial lymphocyte counts in the elderly group (p less than 0.01), with similar counts of IgM and IgG plasma cells, eosinophils, and mast cells in the two groups. There is evidence of significant effects of old age on the mucosal immune system.

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Selected References

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  1. Antonaci S., Jirillo E., Bonomo L. Immunoregulation in aging. Diagn Clin Immunol. 1987;5(2):55–61. [PubMed] [Google Scholar]
  2. Barton J. R., Riad M. A., Gaze M. N., Maran A. G., Ferguson A. Mucosal immunodeficiency in smokers, and in patients with epithelial head and neck tumours. Gut. 1990 Apr;31(4):378–382. doi: 10.1136/gut.31.4.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brandtzaeg P. Human secretory immunoglobulins. VII. Concentrations of parotid IgA and other secretory proteins in relation to the rate of flow and duration of secretory stimulus. Arch Oral Biol. 1971 Nov;16(11):1295–1310. doi: 10.1016/0003-9969(71)90033-1. [DOI] [PubMed] [Google Scholar]
  4. Buckley C. E., 3rd, Buckley E. G., Dorsey F. C. Longitudinal changes in serum immunoglobulin levels in older humans. Fed Proc. 1974 Sep;33(9):2036–2039. [PubMed] [Google Scholar]
  5. Corazza G. R., Frazzoni M., Gatto M. R., Gasbarrini G. Ageing and small-bowel mucosa: a morphometric study. Gerontology. 1986;32(1):60–65. doi: 10.1159/000212766. [DOI] [PubMed] [Google Scholar]
  6. Felser J. M., Raff M. J. Infectious diseases and aging: immunologic perspectives. J Am Geriatr Soc. 1983 Dec;31(12):802–807. doi: 10.1111/j.1532-5415.1983.tb03403.x. [DOI] [PubMed] [Google Scholar]
  7. Ferguson A., Murray D. Quantitation of intraepithelial lymphocytes in human jejunum. Gut. 1971 Dec;12(12):988–994. doi: 10.1136/gut.12.12.988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Finkelstein M. S., Tanner M., Freedman M. L. Salivary and serum IgA levels in a geriatric outpatient population. J Clin Immunol. 1984 Mar;4(2):85–91. doi: 10.1007/BF00915040. [DOI] [PubMed] [Google Scholar]
  9. Goidl E. A., Choy J. W., Gibbons J. J., Weksler M. E., Thorbecke G. J., Siskind G. W. Production of auto-antiidiotypic antibody during the normal immune response. VII. Analysis of the cellular basis for the increased auto-antiidiotype antibody production by aged mice. J Exp Med. 1983 May 1;157(5):1635–1645. doi: 10.1084/jem.157.5.1635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hijmans W., Radl J., Bottazzo G. F., Doniach D. Autoantibodies in highly aged humans. Mech Ageing Dev. 1984 Jul;26(1):83–89. doi: 10.1016/0047-6374(84)90167-2. [DOI] [PubMed] [Google Scholar]
  11. Horan M. A., Fox R. A. Ageing and the immune response--a unifying hypothesis? Mech Ageing Dev. 1984 Aug;26(2-3):165–181. doi: 10.1016/0047-6374(84)90091-5. [DOI] [PubMed] [Google Scholar]
  12. Makinodan T., Kay M. M. Age influence on the immune system. Adv Immunol. 1980;29:287–330. doi: 10.1016/s0065-2776(08)60047-4. [DOI] [PubMed] [Google Scholar]
  13. Nagel J. E., Chopra R. K., Powers D. C., Adler W. H. Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes. Clin Exp Immunol. 1989 Feb;75(2):286–291. [PMC free article] [PubMed] [Google Scholar]
  14. O'Mahony S., Arranz E., Barton J. R., Ferguson A. Dissociation between systemic and mucosal humoral immune responses in coeliac disease. Gut. 1991 Jan;32(1):29–35. doi: 10.1136/gut.32.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. O'Mahony S., Barton J. R., Crichton S., Ferguson A. Appraisal of gut lavage in the study of intestinal humoral immunity. Gut. 1990 Dec;31(12):1341–1344. doi: 10.1136/gut.31.12.1341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Peterson W. J. Immunity, age and loss of immunohomeostasis. Gerodontology. 1984 Winter;3(4):259–269. doi: 10.1111/j.1741-2358.1984.tb00052.x. [DOI] [PubMed] [Google Scholar]
  17. Peterson W. J. Immunity, age and loss of immunohomeostasis. Gerodontology. 1984 Winter;3(4):259–269. doi: 10.1111/j.1741-2358.1984.tb00052.x. [DOI] [PubMed] [Google Scholar]
  18. Phair J. P., Hsu C. S., Hsu Y. L. Ageing and infection. Ciba Found Symp. 1988;134:143–154. doi: 10.1002/9780470513583.ch10. [DOI] [PubMed] [Google Scholar]
  19. Saltzman R. L., Peterson P. K. Immunodeficiency of the elderly. Rev Infect Dis. 1987 Nov-Dec;9(6):1127–1139. doi: 10.1093/clinids/9.6.1127. [DOI] [PubMed] [Google Scholar]
  20. Scott H., Rognum T. O., Midtvedt T., Brandtzaeg P. Age-related changes of human serum antibodies to dietary and colonic bacterial antigens measured by an enzyme-linked immunosorbent assay. Acta Pathol Microbiol Immunol Scand C. 1985 Apr;93(2):65–70. doi: 10.1111/j.1699-0463.1985.tb02924.x. [DOI] [PubMed] [Google Scholar]
  21. Thoman M. L., Weigle W. O. The cellular and subcellular bases of immunosenescence. Adv Immunol. 1989;46:221–261. doi: 10.1016/s0065-2776(08)60655-0. [DOI] [PubMed] [Google Scholar]

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