Skip to main content
NCBI home page
Gut logoLink to Gut
. 1992 Aug;33(8):1029–1032. doi: 10.1136/gut.33.8.1029

Helicobacter pylori and gastric cancer: correlation with gastritis, intestinal metaplasia, and tumour histology.

A Wee 1, J Y Kang 1, M Teh 1
PMCID: PMC1379436  PMID: 1398226

Abstract

This study aimed to examine the association between Helicobacter pylori, histological gastritis, and intestinal metaplasia in gastric cancers of different histological types. A total of 169 gastrectomy specimens received in one pathology department were studied. Altogether 156 were adenocarcinomas (intestinal type 87, diffuse type 50, mixed type 19). Gastritis occurred in 137 of 163 body specimens (84%) and in 126 of 131 antral specimens (96%). Its presence was unrelated to tumour histology. Atrophic gastritis was more common in both body and antral mucosa in intestinal type compared with diffuse type carcinoma. This was also true for intestinal metaplasia of the body, but not of the antral mucosa. H pylori was present in 101 of 163 (62%) body specimens and 56 of 131 (43%) antral specimens. In intestinal type carcinoma, H pylori was found in 52/84 (62%) body specimens and in 24/70 (34%) antral specimens, while the corresponding figures for diffuse type carcinoma were 29/48 (60%) and 17/38 (45%) respectively. Tumour histology therefore had no influence on the occurrence of H pylori. Tumour site had no effect on the presence or absence of gastritis, atrophic changes, intestinal metaplasia, or H pylori. While both H pylori and gastritis are associated with gastric cancer, the association is unrelated to tumour histology and may not be a causal one.

Full text

PDF
1029

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coggon D., Acheson E. D. The geography of cancer of the stomach. Br Med Bull. 1984 Oct;40(4):335–341. doi: 10.1093/oxfordjournals.bmb.a072000. [DOI] [PubMed] [Google Scholar]
  2. Correa P. A human model of gastric carcinogenesis. Cancer Res. 1988 Jul 1;48(13):3554–3560. [PubMed] [Google Scholar]
  3. Forman D., Newell D. G., Fullerton F., Yarnell J. W., Stacey A. R., Wald N., Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991 Jun 1;302(6788):1302–1305. doi: 10.1136/bmj.302.6788.1302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Forman D., Sitas F., Newell D. G., Stacey A. R., Boreham J., Peto R., Campbell T. C., Li J., Chen J. Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer. 1990 Oct 15;46(4):608–611. doi: 10.1002/ijc.2910460410. [DOI] [PubMed] [Google Scholar]
  5. Fox J. G., Correa P., Taylor N. S., Zavala D., Fontham E., Janney F., Rodriguez E., Hunter F., Diavolitsis S. Campylobacter pylori-associated gastritis and immune response in a population at increased risk of gastric carcinoma. Am J Gastroenterol. 1989 Jul;84(7):775–781. [PubMed] [Google Scholar]
  6. Graham D. Y., Evans D. G., Evans D. J., Jr Campylobacter pylori. The organism and its clinical relevance. J Clin Gastroenterol. 1989;11 (Suppl 1):S43–S48. [PubMed] [Google Scholar]
  7. Haenszel W., Kurihara M. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst. 1968 Jan;40(1):43–68. [PubMed] [Google Scholar]
  8. Kang J. Y. Surgery for gastric cancer in Singapore, 1951-1980, with particular reference to racial differences in incidence. Aust N Z J Med. 1988 Aug;18(5):661–664. doi: 10.1111/j.1445-5994.1988.tb00145.x. [DOI] [PubMed] [Google Scholar]
  9. Kang J. Y., Tay H. H., Wee A., Guan R., Math M. V., Yap I. Effect of colloidal bismuth subcitrate on symptoms and gastric histology in non-ulcer dyspepsia. A double blind placebo controlled study. Gut. 1990 Apr;31(4):476–480. doi: 10.1136/gut.31.4.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. doi: 10.1111/apm.1965.64.1.31. [DOI] [PubMed] [Google Scholar]
  11. Loffeld R. J., Willems I., Flendrig J. A., Arends J. W. Helicobacter pylori and gastric carcinoma. Histopathology. 1990 Dec;17(6):537–541. doi: 10.1111/j.1365-2559.1990.tb00793.x. [DOI] [PubMed] [Google Scholar]
  12. McNulty C. A., Gearty J. C., Crump B., Davis M., Donovan I. A., Melikian V., Lister D. M., Wise R. Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J (Clin Res Ed) 1986 Sep 13;293(6548):645–649. doi: 10.1136/bmj.293.6548.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ormand J. E., Talley N. J., Shorter R. G., Conley C. R., Carpenter H. A., Fich A., Wilson W. R., Phillips S. F. Prevalence of Helicobacter pylori in specific forms of gastritis. Further evidence supporting a pathogenic role for H. pylori in chronic nonspecific gastritis. Dig Dis Sci. 1991 Feb;36(2):142–145. doi: 10.1007/BF01300747. [DOI] [PubMed] [Google Scholar]
  14. Parsonnet J., Friedman G. D., Vandersteen D. P., Chang Y., Vogelman J. H., Orentreich N., Sibley R. K. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991 Oct 17;325(16):1127–1131. doi: 10.1056/NEJM199110173251603. [DOI] [PubMed] [Google Scholar]
  15. Parsonnet J., Vandersteen D., Goates J., Sibley R. K., Pritikin J., Chang Y. Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas. J Natl Cancer Inst. 1991 May 1;83(9):640–643. doi: 10.1093/jnci/83.9.640. [DOI] [PubMed] [Google Scholar]
  16. Scott N., Lansdown M., Diament R., Rathbone B., Murday V., Wyatt J. I., McMahon M., Dixon M. F., Quirke P. Helicobacter gastritis and intestinal metaplasia in a gastric cancer family. Lancet. 1990 Mar 24;335(8691):728–728. doi: 10.1016/0140-6736(90)90845-v. [DOI] [PubMed] [Google Scholar]
  17. Sipponen P., Kekki M., Siurala M. Age-related trends of gastritis and intestinal metaplasia in gastric carcinoma patients and in controls representing the population at large. Br J Cancer. 1984 Apr;49(4):521–530. doi: 10.1038/bjc.1984.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sitas F., Forman D., Yarnell J. W., Burr M. L., Elwood P. C., Pedley S., Marks K. J. Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut. 1991 Jan;32(1):25–28. doi: 10.1136/gut.32.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Teh M., Lee Y. S. Intestinal and diffuse carcinoma of the stomach among the ethnic and dialect groups in Singapore. Cancer. 1987 Aug 15;60(4):921–925. doi: 10.1002/1097-0142(19870815)60:4<921::aid-cncr2820600435>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  20. Wee A., Kang J. Y., Ho M. S., Choong H. L., Wu A. Y., Sutherland I. H. Gastroduodenal mucosa in uraemia: endoscopic and histological correlation and prevalence of helicobacter-like organisms. Gut. 1990 Oct;31(10):1093–1096. doi: 10.1136/gut.31.10.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES