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. 1992 Aug;33(8):1134–1145. doi: 10.1136/gut.33.8.1134

Acid-base transport systems in gastrointestinal epithelia.

D Gleeson 1
PMCID: PMC1379458  PMID: 1398242

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahn J., Chang E. B., Field M. Phorbol ester inhibition of Na-H exchange in rabbit proximal colon. Am J Physiol. 1985 Nov;249(5 Pt 1):C527–C530. doi: 10.1152/ajpcell.1985.249.5.C527. [DOI] [PubMed] [Google Scholar]
  2. Argenzio R. A., Whipp S. C. Inter-relationship of sodium, chloride, bicarbonate and acetate transport by the colon of the pig. J Physiol. 1979 Oct;295:365–381. doi: 10.1113/jphysiol.1979.sp012974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aronson P. S. Kinetic properties of the plasma membrane Na+-H+ exchanger. Annu Rev Physiol. 1985;47:545–560. doi: 10.1146/annurev.ph.47.030185.002553. [DOI] [PubMed] [Google Scholar]
  4. Aronson P. S., Nee J., Suhm M. A. Modifier role of internal H+ in activating the Na+-H+ exchanger in renal microvillus membrane vesicles. Nature. 1982 Sep 9;299(5879):161–163. doi: 10.1038/299161a0. [DOI] [PubMed] [Google Scholar]
  5. Banwell J. G., Pierce N. F., Mitra R. C., Brigham K. L., Caranasos G. J., Keimowitz R. I., Fedson D. S., Thomas J., Gorbach S. L., Sack R. B. Intestinal fluid and electrolyte transport in human cholera. J Clin Invest. 1970 Jan;49(1):183–195. doi: 10.1172/JCI106217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Barros F., Domínguez P., Velasco G., Lazo P. S. Na+/H+ exchange is present in basolateral membranes from rabbit small intestine. Biochem Biophys Res Commun. 1986 Jan 29;134(2):827–834. doi: 10.1016/s0006-291x(86)80495-8. [DOI] [PubMed] [Google Scholar]
  7. Benedetti A., Strazzabosco M., Corasanti J. G., Haddad P., Graf J., Boyer J. L. Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH. Am J Physiol. 1991 Sep;261(3 Pt 1):G512–G522. doi: 10.1152/ajpgi.1991.261.3.G512. [DOI] [PubMed] [Google Scholar]
  8. Bieberdorf F. A., Gorden P., Fordtran J. S. Pathogenesis of congenital alkalosis with diarrhea. Implications for the physiology of normal ileal electrolyte absorption and secretion. J Clin Invest. 1972 Aug;51(8):1958–1968. doi: 10.1172/JCI107002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bierman A. J., Cragoe E. J., Jr, de Laat S. W., Moolenaar W. H. Bicarbonate determines cytoplasmic pH and suppresses mitogen-induced alkalinization in fibroblastic cells. J Biol Chem. 1988 Oct 25;263(30):15253–15256. [PubMed] [Google Scholar]
  10. Binder H. J., Foster E. S., Budinger M. E., Hayslett J. P. Mechanism of electroneutral sodium chloride absorption in distal colon of the rat. Gastroenterology. 1987 Sep;93(3):449–455. doi: 10.1016/0016-5085(87)90905-x. [DOI] [PubMed] [Google Scholar]
  11. Binder H. J., Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology. 1989 Apr;96(4):989–996. doi: 10.1016/0016-5085(89)91614-4. [DOI] [PubMed] [Google Scholar]
  12. Booth I. W., Stange G., Murer H., Fenton T. R., Milla P. J. Defective jejunal brush-border Na+/H+ exchange: a cause of congenital secretory diarrhoea. Lancet. 1985 May 11;1(8437):1066–1069. doi: 10.1016/s0140-6736(85)92369-4. [DOI] [PubMed] [Google Scholar]
  13. Boron W. F., Boulpaep E. L. Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport. J Gen Physiol. 1983 Jan;81(1):53–94. doi: 10.1085/jgp.81.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Brasitus T. A., Dudeja P. K., Foster E. S. 1,2-Dimethylhydrazine-induced alterations in Na+-H+ exchange in rat colonic brush-border membrane vesicles. Biochim Biophys Acta. 1988 Mar 3;938(3):483–488. doi: 10.1016/0005-2736(88)90146-0. [DOI] [PubMed] [Google Scholar]
  15. Brown C. D., Dunk C. R., Turnberg L. A. Cl-HCO3 exchange and anion conductance in rat duodenal apical membrane vesicles. Am J Physiol. 1989 Oct;257(4 Pt 1):G661–G667. doi: 10.1152/ajpgi.1989.257.4.G661. [DOI] [PubMed] [Google Scholar]
  16. Buanes T., Grotmol T., Landsverk T., Raeder M. G. Secretin empties bile duct cell cytoplasm of vesicles when it initiates ductular HCO3- secretion in the pig. Gastroenterology. 1988 Aug;95(2):417–424. doi: 10.1016/0016-5085(88)90499-4. [DOI] [PubMed] [Google Scholar]
  17. Busa W. B. Mechanisms and consequences of pH-mediated cell regulation. Annu Rev Physiol. 1986;48:389–402. doi: 10.1146/annurev.ph.48.030186.002133. [DOI] [PubMed] [Google Scholar]
  18. Cassano G., Stieger B., Murer H. Na/H- and Cl/OH-exchange in rat jejunal and rat proximal tubular brush border membrane vesicles. Studies with acridine orange. Pflugers Arch. 1984 Mar;400(3):309–317. doi: 10.1007/BF00581565. [DOI] [PubMed] [Google Scholar]
  19. Chang E. B., Field M., Miller R. J. alpha 2-Adrenergic receptor regulation of ion transport in rabbit ileum. Am J Physiol. 1982 Mar;242(3):G237–G242. doi: 10.1152/ajpgi.1982.242.3.G237. [DOI] [PubMed] [Google Scholar]
  20. Chang E. B., Musch M. W., Mayer L. Interleukins 1 and 3 stimulate anion secretion in chicken intestine. Gastroenterology. 1990 Jun;98(6):1518–1524. doi: 10.1016/0016-5085(90)91084-j. [DOI] [PubMed] [Google Scholar]
  21. Chiba T., Fisher S. K., Park J., Seguin E. B., Agranoff B. W., Yamada T. Carbamoylcholine and gastrin induce inositol lipid turnover in canine gastric parietal cells. Am J Physiol. 1988 Jul;255(1 Pt 1):G99–105. doi: 10.1152/ajpgi.1988.255.1.G99. [DOI] [PubMed] [Google Scholar]
  22. Clark J. D., Limbird L. E. Na(+)-H+ exchanger subtypes: a predictive review. Am J Physiol. 1991 Dec;261(6 Pt 1):C945–C953. doi: 10.1152/ajpcell.1991.261.6.C945. [DOI] [PubMed] [Google Scholar]
  23. Corasanti J. G., Gleeson D., Boyer J. L. Effects of osmotic stresses on isolated rat hepatocytes. I. Ionic mechanisms of cell volume regulation. Am J Physiol. 1990 Feb;258(2 Pt 1):G290–G298. doi: 10.1152/ajpgi.1990.258.2.G290. [DOI] [PubMed] [Google Scholar]
  24. Cummings J. H. Short chain fatty acids in the human colon. Gut. 1981 Sep;22(9):763–779. doi: 10.1136/gut.22.9.763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Cuppoletti J., Sachs G. Regulation of gastric acid secretion via modulation of a chloride conductance. J Biol Chem. 1984 Dec 10;259(23):14952–14959. [PubMed] [Google Scholar]
  26. Curci S., Debellis L., Frömter E. Evidence for rheogenic sodium bicarbonate cotransport in the basolateral membrane of oxyntic cells of frog gastric fundus. Pflugers Arch. 1987 May;408(5):497–504. doi: 10.1007/BF00585075. [DOI] [PubMed] [Google Scholar]
  27. Davis G. R., Morawski S. G., Santa Ana C. A., Fordtran J. S. Evaluation of chloride/bicarbonate. Exchange in the human colon in vivo. J Clin Invest. 1983 Feb;71(2):201–207. doi: 10.1172/JCI110760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. DeSoignie R., Sellin J. H. Acid-base regulation of ion transport in rabbit ileum in vitro. Gastroenterology. 1990 Jul;99(1):132–141. doi: 10.1016/0016-5085(90)91240-7. [DOI] [PubMed] [Google Scholar]
  29. Devroede G. J., Phillips S. F. Conservation of sodium, chloride, and water by the human colon. Gastroenterology. 1969 Jan;56(1):101–109. [PubMed] [Google Scholar]
  30. Dharmsathaphorn K., Huott P. A., Vongkovit P., Beuerlein G., Pandol S. J., Ammon H. V. Cl- secretion induced by bile salts. A study of the mechanism of action based on a cultured colonic epithelial cell line. J Clin Invest. 1989 Sep;84(3):945–953. doi: 10.1172/JCI114257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Donowitz M., Binder H. J. Effect of enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae type 1 on fluid and electrolyte transport in the colon. J Infect Dis. 1976 Aug;134(2):135–143. doi: 10.1093/infdis/134.2.135. [DOI] [PubMed] [Google Scholar]
  32. Donowitz M., Welsh M. J. Ca2+ and cyclic AMP in regulation of intestinal Na, K, and Cl transport. Annu Rev Physiol. 1986;48:135–150. doi: 10.1146/annurev.ph.48.030186.001031. [DOI] [PubMed] [Google Scholar]
  33. Dudeja P. K., Foster E. S., Brasitus T. A. Na+-H+ antiporter of rat colonic basolateral membrane vesicles. Am J Physiol. 1989 Oct;257(4 Pt 1):G624–G632. doi: 10.1152/ajpgi.1989.257.4.G624. [DOI] [PubMed] [Google Scholar]
  34. Duffey M. E., Devor D. C. Intracellular pH and membrane potassium conductance in rabbit distal colon. Am J Physiol. 1990 Feb;258(2 Pt 1):C336–C343. doi: 10.1152/ajpcell.1990.258.2.C336. [DOI] [PubMed] [Google Scholar]
  35. Dumont M., Erlinger S., Uchman S. Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocholic acid in the rat: possible role of bicarbonate transport. Gastroenterology. 1980 Jul;79(1):82–89. [PubMed] [Google Scholar]
  36. Dunk C. R., Brown C. D., Turnberg L. A. Stimulation of Cl/HCO3 exchange in rat duodenal brush border membrane vesicles by cAMP. Pflugers Arch. 1989 Sep;414(6):701–705. doi: 10.1007/BF00582138. [DOI] [PubMed] [Google Scholar]
  37. Emmer E., Rood R. P., Wesolek J. H., Cohen M. E., Braithwaite R. S., Sharp G. W., Murer H., Donowitz M. Role of calcium and calmodulin in the regulation of the rabbit ileal brush-border membrane Na+/H+ antiporter. J Membr Biol. 1989 Jun;108(3):207–215. doi: 10.1007/BF01871735. [DOI] [PubMed] [Google Scholar]
  38. Ericson A. C., Spring K. R. Volume regulation by Necturus gallbladder: apical Na+-H+ and Cl(-)-HCO-3 exchange. Am J Physiol. 1982 Sep;243(3):C146–C150. doi: 10.1152/ajpcell.1982.243.3.C146. [DOI] [PubMed] [Google Scholar]
  39. Fidelman M. L., Seeholzer S. H., Walsh K. B., Moore R. D. Intracellular pH mediates action of insulin on glycolysis in frog skeletal muscle. Am J Physiol. 1982 Jan;242(1):C87–C93. doi: 10.1152/ajpcell.1982.242.1.C87. [DOI] [PubMed] [Google Scholar]
  40. Field M., Rao M. C., Chang E. B. Intestinal electrolyte transport and diarrheal disease (1). N Engl J Med. 1989 Sep 21;321(12):800–806. doi: 10.1056/NEJM198909213211206. [DOI] [PubMed] [Google Scholar]
  41. Fleming S. E., Arce D. S. Volatile fatty acids: their production, absorption, utilization, and roles in human health. Clin Gastroenterol. 1986 Oct;15(4):787–814. [PubMed] [Google Scholar]
  42. Flemstrom G., Garner A. Gastroduodenal HCO3(-) transport: characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol. 1982 Mar;242(3):G183–G193. doi: 10.1152/ajpgi.1982.242.3.G183. [DOI] [PubMed] [Google Scholar]
  43. Forte J. G., Black J. A., Forte T. M., Machen T. E., Wolosin J. M. Ultrastructural changes related to functional activity in gastric oxyntic cells. Am J Physiol. 1981 Nov;241(5):G349–G358. doi: 10.1152/ajpgi.1981.241.5.G349. [DOI] [PubMed] [Google Scholar]
  44. Forte J. G., Machen T. E., Obrink K. J. Mechanisms of gastric H+ and Cl- transport. Annu Rev Physiol. 1980;42:111–126. doi: 10.1146/annurev.ph.42.030180.000551. [DOI] [PubMed] [Google Scholar]
  45. Foster E. S., Budinger M. E., Hayslett J. P., Binder H. J. Ion transport in proximal colon of the rat. Sodium depletion stimulates neutral sodium chloride absorption. J Clin Invest. 1986 Jan;77(1):228–235. doi: 10.1172/JCI112281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Foster E. S., Dudeja P. K., Brasitus T. A. Contribution of Cl(-)-OH- exchange to electroneutral NaCl absorption in rat distal colon. Am J Physiol. 1990 Feb;258(2 Pt 1):G261–G267. doi: 10.1152/ajpgi.1990.258.2.G261. [DOI] [PubMed] [Google Scholar]
  47. Foster E. S., Dudeja P. K., Brasitus T. A. Na+-H+ exchange in rat colonic brush-border membrane vesicles. Am J Physiol. 1986 Jun;250(6 Pt 1):G781–G787. doi: 10.1152/ajpgi.1986.250.6.G781. [DOI] [PubMed] [Google Scholar]
  48. Foster E. S., Zimmerman T. W., Hayslett J. P., Binder H. J. Corticosteroid alteration of active electrolyte transport in rat distal colon. Am J Physiol. 1983 Nov;245(5 Pt 1):G668–G675. doi: 10.1152/ajpgi.1983.245.5.G668. [DOI] [PubMed] [Google Scholar]
  49. Frizzell R. A., Dugas M. C., Schultz S. G. Sodium chloride transport by rabbit gallbladder. Direct evidence for a coupled NaCl influx process. J Gen Physiol. 1975 Jun;65(6):769–795. doi: 10.1085/jgp.65.6.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Frizzell R. A., Koch M. J., Schultz S. G. Ion transport by rabbit colon. I. Active and passive components. J Membr Biol. 1976;27(3):297–316. doi: 10.1007/BF01869142. [DOI] [PubMed] [Google Scholar]
  51. Ganapathy V., Leibach F. H. Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline. J Biol Chem. 1983 Dec 10;258(23):14189–14192. [PubMed] [Google Scholar]
  52. Ganz M. B., Boyarsky G., Sterzel R. B., Boron W. F. Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems. Nature. 1989 Feb 16;337(6208):648–651. doi: 10.1038/337648a0. [DOI] [PubMed] [Google Scholar]
  53. Gaskin K. J., Durie P. R., Corey M., Wei P., Forstner G. G. Evidence for a primary defect of pancreatic HCO3-secretion in cystic fibrosis. Pediatr Res. 1982 Jul;16(7):554–557. doi: 10.1203/00006450-198207000-00012. [DOI] [PubMed] [Google Scholar]
  54. Gleeson D., Corasanti J. G., Boyer J. L. Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH. Am J Physiol. 1990 Feb;258(2 Pt 1):G299–G307. doi: 10.1152/ajpgi.1990.258.2.G299. [DOI] [PubMed] [Google Scholar]
  55. Gleeson D., Hood K. A., Murphy G. M., Dowling R. H. Calcium and carbonate ion concentrations in gallbladder and hepatic bile. Gastroenterology. 1992 May;102(5):1707–1716. doi: 10.1016/0016-5085(92)91734-l. [DOI] [PubMed] [Google Scholar]
  56. Gleeson D., Ruppin D. C., Saunders A., Murphy G. M., Dowling R. H. Final outcome of ursodeoxycholic acid treatment in 126 patients with radiolucent gallstones. Q J Med. 1990 Jul;76(279):711–729. [PubMed] [Google Scholar]
  57. Gleeson D., Smith N. D., Boyer J. L. Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport. J Clin Invest. 1989 Jul;84(1):312–321. doi: 10.1172/JCI114156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Goldfarb D. S., Egnor R. W., Charney A. N. Effects of acid-base variables on ion transport in rat colon. J Clin Invest. 1988 Jun;81(6):1903–1910. doi: 10.1172/JCI113537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Goodrich A. L., Suchy F. J. Na(+)-H+ exchange in basolateral plasma membrane vesicles from neonatal rat liver. Am J Physiol. 1990 Sep;259(3 Pt 1):G334–G339. doi: 10.1152/ajpgi.1990.259.3.G334. [DOI] [PubMed] [Google Scholar]
  60. Goré J., Hoinard C. Na+/H+ exchange in isolated hamster enterocytes. Its major role in intracellular pH regulation. Gastroenterology. 1989 Oct;97(4):882–887. doi: 10.1016/0016-5085(89)91492-3. [DOI] [PubMed] [Google Scholar]
  61. Gray M. A., Greenwell J. R., Argent B. E. Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells. J Membr Biol. 1988 Oct;105(2):131–142. doi: 10.1007/BF02009166. [DOI] [PubMed] [Google Scholar]
  62. Grinstein S., Rothstein A. Mechanisms of regulation of the Na+/H+ exchanger. J Membr Biol. 1986;90(1):1–12. doi: 10.1007/BF01869680. [DOI] [PubMed] [Google Scholar]
  63. Grinstein S., Rothstein A., Sarkadi B., Gelfand E. W. Responses of lymphocytes to anisotonic media: volume-regulating behavior. Am J Physiol. 1984 Mar;246(3 Pt 1):C204–C215. doi: 10.1152/ajpcell.1984.246.3.C204. [DOI] [PubMed] [Google Scholar]
  64. Grinstein S., Rotin D., Mason M. J. Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta. 1989 Jan 18;988(1):73–97. doi: 10.1016/0304-4157(89)90004-x. [DOI] [PubMed] [Google Scholar]
  65. Gunther R. D., Bassilian S., Rabon E. C. Cation transport in vesicles from secreting rabbit stomach. J Biol Chem. 1987 Oct 15;262(29):13966–13972. [PubMed] [Google Scholar]
  66. Gurantz D., Schteingart C. D., Hagey L. R., Steinbach J. H., Grotmol T., Hofmann A. F. Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids. Hepatology. 1991 Mar;13(3):540–550. [PubMed] [Google Scholar]
  67. HOGBEN C. A., TOCCO D. J., BRODIE B. B., SCHANKER L. S. On the mechanism of intestinal absorption of drugs. J Pharmacol Exp Ther. 1959 Apr;125(4):275–282. [PubMed] [Google Scholar]
  68. Haggerty J. G., Agarwal N., Reilly R. F., Adelberg E. A., Slayman C. W. Pharmacologically different Na/H antiporters on the apical and basolateral surfaces of cultured porcine kidney cells (LLC-PK1). Proc Natl Acad Sci U S A. 1988 Sep;85(18):6797–6801. doi: 10.1073/pnas.85.18.6797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Hardison W. G., Wood C. A. Importance of bicarbonate in bile salt independent fraction of bile flow. Am J Physiol. 1978 Aug;235(2):E158–E164. doi: 10.1152/ajpendo.1978.235.2.E158. [DOI] [PubMed] [Google Scholar]
  70. Harig J. M., Soergel K. H., Barry J. A., Ramaswamy K. Transport of propionate by human ileal brush-border membrane vesicles. Am J Physiol. 1991 May;260(5 Pt 1):G776–G782. doi: 10.1152/ajpgi.1991.260.5.G776. [DOI] [PubMed] [Google Scholar]
  71. Hatch M., Freel R. W., Goldner A. M., Earnest D. L. Oxalate and chloride absorption by the rabbit colon: sensitivity to metabolic and anion transport inhibitors. Gut. 1984 Mar;25(3):232–237. doi: 10.1136/gut.25.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Hebert S. C. Hypertonic cell volume regulation in mouse thick limbs. II. Na+-H+ and Cl(-)-HCO3- exchange in basolateral membranes. Am J Physiol. 1986 Jun;250(6 Pt 1):C920–C931. doi: 10.1152/ajpcell.1986.250.6.C920. [DOI] [PubMed] [Google Scholar]
  73. Henderson R. M., Krumpholz B., Boyer J. L., Graf J. Effect of intracellular pH on potassium conductance in liver. Pflugers Arch. 1988 Aug;412(3):334–335. doi: 10.1007/BF00582518. [DOI] [PubMed] [Google Scholar]
  74. Hersey S. J., Steiner L. Stimulation of acid formation in permeable gastric glands by valinomycin. Am J Physiol. 1988 Sep;255(3 Pt 1):G313–G318. doi: 10.1152/ajpgi.1988.255.3.G313. [DOI] [PubMed] [Google Scholar]
  75. Hirose R., Chang E. B. Effects of serotonin on Na+-H+ exchange and intracellular calcium in isolated chicken enterocytes. Am J Physiol. 1988 Jun;254(6 Pt 1):G891–G897. doi: 10.1152/ajpgi.1988.254.6.G891. [DOI] [PubMed] [Google Scholar]
  76. Hoffmann E. K., Simonsen L. O. Membrane mechanisms in volume and pH regulation in vertebrate cells. Physiol Rev. 1989 Apr;69(2):315–382. doi: 10.1152/physrev.1989.69.2.315. [DOI] [PubMed] [Google Scholar]
  77. Hopfer U., Liedtke C. M. Proton and bicarbonate transport mechanisms in the intestine. Annu Rev Physiol. 1987;49:51–67. doi: 10.1146/annurev.ph.49.030187.000411. [DOI] [PubMed] [Google Scholar]
  78. Im W. B., Blakeman D. P., Davis J. P. Studies on K+ permeability of rat gastric microsomes. J Biol Chem. 1985 Aug 5;260(16):9452–9460. [PubMed] [Google Scholar]
  79. Johnson L. R. Regulation of gastrointestinal mucosal growth. Physiol Rev. 1988 Apr;68(2):456–502. doi: 10.1152/physrev.1988.68.2.456. [DOI] [PubMed] [Google Scholar]
  80. Kaunitz J. D., Sachs G. Identification of a vanadate-sensitive potassium-dependent proton pump from rabbit colon. J Biol Chem. 1986 Oct 25;261(30):14005–14010. [PubMed] [Google Scholar]
  81. Kikuchi K., Abumrad N. N., Ghishan F. K. Na+/H+ exchange by brush border membrane vesicles of human ileal small intestine. Gastroenterology. 1988 Aug;95(2):388–393. doi: 10.1016/0016-5085(88)90495-7. [DOI] [PubMed] [Google Scholar]
  82. Kinsella J. L., Freiberg J. M., Sacktor B. Glucocorticoid activation of Na+/H+ exchange in renal brush border vesicles: kinetic effects. Am J Physiol. 1985 Feb;248(2 Pt 2):F233–F239. doi: 10.1152/ajprenal.1985.248.2.F233. [DOI] [PubMed] [Google Scholar]
  83. Kitis G., Lucas M. L., Bishop H., Sargent A., Schneider R. E., Blair J. A., Allan R. N. Altered jejunal surface pH in coeliac disease: its effect on propranolol and folic acid absorption. Clin Sci (Lond) 1982 Oct;63(4):373–380. doi: 10.1042/cs0630373. [DOI] [PubMed] [Google Scholar]
  84. Kleinman J. G., Harig J. M., Barry J. A., Ramaswamy K. Na+ and H+ transport in human jejunal brush-border membrane vesicles. Am J Physiol. 1988 Aug;255(2 Pt 1):G206–G211. doi: 10.1152/ajpgi.1988.255.2.G206. [DOI] [PubMed] [Google Scholar]
  85. Knickelbein R. G., Aronson P. S., Dobbins J. W. Characterization of Na(+)-H+ exchangers on villus cells in rabbit ileum. Am J Physiol. 1990 Nov;259(5 Pt 1):G802–G806. doi: 10.1152/ajpgi.1990.259.5.G802. [DOI] [PubMed] [Google Scholar]
  86. Knickelbein R., Aronson P. S., Atherton W., Dobbins J. W. Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange. Am J Physiol. 1983 Oct;245(4):G504–G510. doi: 10.1152/ajpgi.1983.245.4.G504. [DOI] [PubMed] [Google Scholar]
  87. Knickelbein R., Aronson P. S., Schron C. M., Seifter J., Dobbins J. W. Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling. Am J Physiol. 1985 Aug;249(2 Pt 1):G236–G245. doi: 10.1152/ajpgi.1985.249.2.G236. [DOI] [PubMed] [Google Scholar]
  88. Knyrim K., Vakil N., Pfab R., Classen M. The effects of intraduodenal bile acid administration on biliary secretion of ionized calcium and carbonate in man. Hepatology. 1989 Aug;10(2):134–142. doi: 10.1002/hep.1840100203. [DOI] [PubMed] [Google Scholar]
  89. Kopito R. R., Lodish H. F. Primary structure and transmembrane orientation of the murine anion exchange protein. Nature. 1985 Jul 18;316(6025):234–238. doi: 10.1038/316234a0. [DOI] [PubMed] [Google Scholar]
  90. Kuijpers G. A., De Pont J. J. Role of proton and bicarbonate transport in pancreatic cell function. Annu Rev Physiol. 1987;49:87–103. doi: 10.1146/annurev.ph.49.030187.000511. [DOI] [PubMed] [Google Scholar]
  91. Lake J. R., Van Dyke R. W., Scharschmidt B. F. Effects of Na+ replacement and amiloride on ursodeoxycholic acid-stimulated choleresis and biliary bicarbonate secretion. Am J Physiol. 1987 Feb;252(2 Pt 1):G163–G169. doi: 10.1152/ajpgi.1987.252.2.G163. [DOI] [PubMed] [Google Scholar]
  92. Lau K. R., Elliott A. C., Brown P. D. Acetylcholine-induced intracellular acidosis in rabbit salivary gland acinar cells. Am J Physiol. 1989 Feb;256(2 Pt 1):C288–C295. doi: 10.1152/ajpcell.1989.256.2.C288. [DOI] [PubMed] [Google Scholar]
  93. Liedtke C. M., Hopfer U. Mechanism of Cl- translocation across small intestinal brush-border membrane. II. Demonstration of Cl--OH- exchange and Cl- conductance. Am J Physiol. 1982 Mar;242(3):G272–G280. doi: 10.1152/ajpgi.1982.242.3.G272. [DOI] [PubMed] [Google Scholar]
  94. Ljungström M., Chew C. S. Calcium oscillations and morphological transformations in single cultured gastric parietal cells. Am J Physiol. 1991 Jan;260(1 Pt 1):C67–C78. doi: 10.1152/ajpcell.1991.260.1.C67. [DOI] [PubMed] [Google Scholar]
  95. Lucas M. L., Blair J. A. The magnitude and distribution of the acid microclimate in proximal jejunum and its relation to luminal acidification. Proc R Soc Lond B Biol Sci. 1978 Jan 24;200(1138):27–41. doi: 10.1098/rspb.1978.0003. [DOI] [PubMed] [Google Scholar]
  96. Lucas M. L., Cooper B. T., Lei F. H., Johnson I. T., Holmes G. K., Blair J. A., Cooke W. T. Acid microclimate in coeliac and Crohn's disease: a model for folate malabsorption. Gut. 1978 Aug;19(8):735–742. doi: 10.1136/gut.19.8.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Lucas M. L., Lei F. H., Blair J. A. The influence of buffer pH, glucose and sodium ion concentration on the acid microclimate in rat proximal jejunum in vitro. Pflugers Arch. 1980 May;385(2):137–142. doi: 10.1007/BF00588693. [DOI] [PubMed] [Google Scholar]
  98. Lübcke R., Haag K., Berger E., Knauf H., Gerok W. Ion transport in rat proximal colon in vivo. Am J Physiol. 1986 Jul;251(1 Pt 1):G132–G139. doi: 10.1152/ajpgi.1986.251.1.G132. [DOI] [PubMed] [Google Scholar]
  99. MacLeod R. J., Hamilton J. R. Regulatory volume increase in mammalian jejunal villus cells is due to bumetanide-sensitive NaKCl2 cotransport. Am J Physiol. 1990 May;258(5 Pt 1):G665–G674. doi: 10.1152/ajpgi.1990.258.5.G665. [DOI] [PubMed] [Google Scholar]
  100. Machen T. E., Paradiso A. M. Regulation of intracellular pH in the stomach. Annu Rev Physiol. 1987;49:19–33. doi: 10.1146/annurev.ph.49.030187.000315. [DOI] [PubMed] [Google Scholar]
  101. Manganel M., Turner R. J. Rapid secretagogue-induced activation of Na+H+ exchange in rat parotid acinar cells. Possible interrelationship between volume regulation and stimulus-secretion coupling. J Biol Chem. 1991 Jun 5;266(16):10182–10188. [PubMed] [Google Scholar]
  102. Marteau C., Sastre B., Iconomidis N., Portugal H., Pauli A. M., Gérolami A. pH regulation in human gallbladder bile: study in patients with and without gallstones. Hepatology. 1990 Jun;11(6):997–1002. doi: 10.1002/hep.1840110614. [DOI] [PubMed] [Google Scholar]
  103. Mascolo N., Rajendran V. M., Binder H. J. Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon. Gastroenterology. 1991 Aug;101(2):331–338. doi: 10.1016/0016-5085(91)90008-9. [DOI] [PubMed] [Google Scholar]
  104. Mason M. J., Smith J. D., Garcia-Soto J. J., Grinstein S. Internal pH-sensitive site couples Cl-(-)HCO3- exchange to Na+-H+ antiport in lymphocytes. Am J Physiol. 1989 Feb;256(2 Pt 1):C428–C433. doi: 10.1152/ajpcell.1989.256.2.C428. [DOI] [PubMed] [Google Scholar]
  105. Maton P. N. Omeprazole. N Engl J Med. 1991 Apr 4;324(14):965–975. doi: 10.1056/NEJM199104043241406. [DOI] [PubMed] [Google Scholar]
  106. McEwan G. T., Daniel H., Fett C., Burgess M. N., Lucas M. L. The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo. Proc R Soc Lond B Biol Sci. 1988 Jul 22;234(1275):219–237. doi: 10.1098/rspb.1988.0045. [DOI] [PubMed] [Google Scholar]
  107. McGowan K., Piver G., Stoff J. S., Donowitz M. Role of prostaglandins and calcium in the effects of Entamoeba histolytica on colonic electrolyte transport. Gastroenterology. 1990 Apr;98(4):873–880. doi: 10.1016/0016-5085(90)90010-x. [DOI] [PubMed] [Google Scholar]
  108. Meier P. J., Knickelbein R., Moseley R. H., Dobbins J. W., Boyer J. L. Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles. J Clin Invest. 1985 Apr;75(4):1256–1263. doi: 10.1172/JCI111824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Moolenaar W. H. Effects of growth factors on intracellular pH regulation. Annu Rev Physiol. 1986;48:363–376. doi: 10.1146/annurev.ph.48.030186.002051. [DOI] [PubMed] [Google Scholar]
  110. Moore W. L., Jr, Bieberdorf F. A., Morawski S. G., Finkelstein R. A., Fordtran J. S. Ion transport during cholera-induced ileal secretion in the dog. J Clin Invest. 1971 Feb;50(2):312–318. doi: 10.1172/JCI106496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Moran W. M., Hudson R. L., Schultz S. G. Transcellular sodium transport and intracellular sodium activities in rabbit gallbladder. Am J Physiol. 1986 Jul;251(1 Pt 1):G155–G159. doi: 10.1152/ajpgi.1986.251.1.G155. [DOI] [PubMed] [Google Scholar]
  112. Muallem S., Blissard D., Cragoe E. J., Jr, Sachs G. Activation of the Na+/H+ and Cl-/HCO3- exchange by stimulation of acid secretion in the parietal cell. J Biol Chem. 1988 Oct 15;263(29):14703–14711. [PubMed] [Google Scholar]
  113. Muallem S., Burnham C., Blissard D., Berglindh T., Sachs G. Electrolyte transport across the basolateral membrane of the parietal cells. J Biol Chem. 1985 Jun 10;260(11):6641–6653. [PubMed] [Google Scholar]
  114. Muallem S., Loessberg P. A. Intracellular pH-regulatory mechanisms in pancreatic acinar cells. I. Characterization of H+ and HCO3- transporters. J Biol Chem. 1990 Aug 5;265(22):12806–12812. [PubMed] [Google Scholar]
  115. Mugharbil A., Knickelbein R. G., Aronson P. S., Dobbins J. W. Rabbit ileal brush-border membrane Cl-HCO3 exchanger is activated by an internal pH-sensitive modifier site. Am J Physiol. 1990 Oct;259(4 Pt 1):G666–G670. doi: 10.1152/ajpgi.1990.259.4.G666. [DOI] [PubMed] [Google Scholar]
  116. Murer H., Hopfer U., Kinne R. Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney. Biochem J. 1976 Mar 15;154(3):597–604. [PMC free article] [PubMed] [Google Scholar]
  117. Negulescu P. A., Reenstra W. W., Machen T. E. Intracellular Ca requirements for stimulus-secretion coupling in parietal cell. Am J Physiol. 1989 Feb;256(2 Pt 1):C241–C251. doi: 10.1152/ajpcell.1989.256.2.C241. [DOI] [PubMed] [Google Scholar]
  118. Nellans H. N., Frizzell R. A., Schultz S. G. Brush-border processes and transepithelial Na and Cl transport by rabbit ileum. Am J Physiol. 1974 May;226(5):1131–1141. doi: 10.1152/ajplegacy.1974.226.5.1131. [DOI] [PubMed] [Google Scholar]
  119. Nellans H. N., Frizzell R. A., Schultz S. G. Effect of acetazolamide on sodium and chloride transport by in vitro rabbit ileum. Am J Physiol. 1975 Jun;228(6):1808–1814. doi: 10.1152/ajplegacy.1975.228.6.1808. [DOI] [PubMed] [Google Scholar]
  120. Nord E. P., Howard M. J., Hafezi A., Moradeshagi P., Vaystub S., Insel P. A. Alpha 2 adrenergic agonists stimulate Na+-H+ antiport activity in the rabbit renal proximal tubule. J Clin Invest. 1987 Dec;80(6):1755–1762. doi: 10.1172/JCI113268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Nylander O., Flemström G. Effects of alpha-adrenoceptor agonists and antagonists on duodenal surface epithelial HCO3-secretion in the rat in vivo. Acta Physiol Scand. 1986 Mar;126(3):433–441. doi: 10.1111/j.1748-1716.1986.tb07838.x. [DOI] [PubMed] [Google Scholar]
  122. Palmer K. R., Gurantz D., Hofmann A. F., Clayton L. M., Hagey L. R., Cecchetti S. Hypercholeresis induced by norchenodeoxycholate in biliary fistula rodent. Am J Physiol. 1987 Feb;252(2 Pt 1):G219–G228. doi: 10.1152/ajpgi.1987.252.2.G219. [DOI] [PubMed] [Google Scholar]
  123. Paradiso A. M., Townsley M. C., Wenzl E., Machen T. E. Regulation of intracellular pH in resting and in stimulated parietal cells. Am J Physiol. 1989 Sep;257(3 Pt 1):C554–C561. doi: 10.1152/ajpcell.1989.257.3.C554. [DOI] [PubMed] [Google Scholar]
  124. Paradiso A. M., Tsien R. Y., Demarest J. R., Machen T. E. Na-H and Cl-HCO3 exchange in rabbit oxyntic cells using fluorescence microscopy. Am J Physiol. 1987 Jul;253(1 Pt 1):C30–C36. doi: 10.1152/ajpcell.1987.253.1.C30. [DOI] [PubMed] [Google Scholar]
  125. Perez A., Blissard D., Sachs G., Hersey S. J. Evidence for a chloride conductance in secretory membrane of parietal cells. Am J Physiol. 1989 Feb;256(2 Pt 1):G299–G305. doi: 10.1152/ajpgi.1989.256.2.G299. [DOI] [PubMed] [Google Scholar]
  126. Perona R., Serrano R. Increased pH and tumorigenicity of fibroblasts expressing a yeast proton pump. Nature. 1988 Aug 4;334(6181):438–440. doi: 10.1038/334438a0. [DOI] [PubMed] [Google Scholar]
  127. Podesta R. B., Mettrick D. F. HCO3- and H+ secretion in rat ileum in vivo. Am J Physiol. 1977 Jun;232(6):E574–E579. doi: 10.1152/ajpendo.1977.232.6.E574. [DOI] [PubMed] [Google Scholar]
  128. Puurunen J., Schwabe U. Effect of gastric secretagogues on the formation of inositol phosphates in isolated gastric cells of the rat. Br J Pharmacol. 1987 Mar;90(3):479–490. doi: 10.1111/j.1476-5381.1987.tb11197.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  129. Rabon E. C., Reuben M. A. The mechanism and structure of the gastric H,K-ATPase. Annu Rev Physiol. 1990;52:321–344. doi: 10.1146/annurev.ph.52.030190.001541. [DOI] [PubMed] [Google Scholar]
  130. Rajendran V. M., Binder H. J. Characterization of Na-H exchange in apical membrane vesicles of rat colon. J Biol Chem. 1990 May 25;265(15):8408–8414. [PubMed] [Google Scholar]
  131. Rajendran V. M., Kashgarian M., Binder H. J. Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon. J Biol Chem. 1989 Nov 5;264(31):18638–18644. [PubMed] [Google Scholar]
  132. Rajendran V. M., Oesterlin M., Binder H. J. Sodium uptake across basolateral membrane of rat distal colon. Evidence for Na-H exchange and Na-anion cotransport. J Clin Invest. 1991 Oct;88(4):1379–1385. doi: 10.1172/JCI115444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Ramaswamy K., Harig J. M., Kleinman J. G., Harris M. S., Barry J. A. Sodium-proton exchange in human ileal brush-border membrane vesicles. Biochim Biophys Acta. 1989 Jun 6;981(2):193–199. doi: 10.1016/0005-2736(89)90028-x. [DOI] [PubMed] [Google Scholar]
  134. Reenstra W. W., Forte J. G. Characterization of K+ and Cl- conductances in apical membrane vesicles from stimulated rabbit oxyntic cells. Am J Physiol. 1990 Nov;259(5 Pt 1):G850–G858. doi: 10.1152/ajpgi.1990.259.5.G850. [DOI] [PubMed] [Google Scholar]
  135. Reuss L. Ion transport across gallbladder epithelium. Physiol Rev. 1989 Apr;69(2):503–545. doi: 10.1152/physrev.1989.69.2.503. [DOI] [PubMed] [Google Scholar]
  136. Reuss L., Segal Y., Altenberg G. Regulation of ion transport across gallbladder epithelium. Annu Rev Physiol. 1991;53:361–373. doi: 10.1146/annurev.ph.53.030191.002045. [DOI] [PubMed] [Google Scholar]
  137. Roos A., Boron W. F. Intracellular pH. Physiol Rev. 1981 Apr;61(2):296–434. doi: 10.1152/physrev.1981.61.2.296. [DOI] [PubMed] [Google Scholar]
  138. Ruppin H., Bar-Meir S., Soergel K. H., Wood C. M., Schmitt M. G., Jr Absorption of short-chain fatty acids by the colon. Gastroenterology. 1980 Jun;78(6):1500–1507. [PubMed] [Google Scholar]
  139. Rübsamen K., von Engelhardt W. Absorption of Na, H ions and short chain fatty acids from the sheep colon. Pflugers Arch. 1981 Aug;391(2):141–146. doi: 10.1007/BF00657005. [DOI] [PubMed] [Google Scholar]
  140. Sachs G., Carlsson E., Lindberg P., Wallmark B. Gastric H,K-ATPase as therapeutic target. Annu Rev Pharmacol Toxicol. 1988;28:269–284. doi: 10.1146/annurev.pa.28.040188.001413. [DOI] [PubMed] [Google Scholar]
  141. Sachs G. The parietal cell as a therapeutic target. Scand J Gastroenterol Suppl. 1986;118:1–10. doi: 10.3109/00365528609090880. [DOI] [PubMed] [Google Scholar]
  142. Sardet C., Counillon L., Franchi A., Pouysségur J. Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD. Science. 1990 Feb 9;247(4943):723–726. doi: 10.1126/science.2154036. [DOI] [PubMed] [Google Scholar]
  143. Sardet C., Franchi A., Pouysségur J. Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter. Cell. 1989 Jan 27;56(2):271–280. doi: 10.1016/0092-8674(89)90901-x. [DOI] [PubMed] [Google Scholar]
  144. Schoumacher R. A., Shoemaker R. L., Halm D. R., Tallant E. A., Wallace R. W., Frizzell R. A. Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells. Nature. 1987 Dec 24;330(6150):752–754. doi: 10.1038/330752a0. [DOI] [PubMed] [Google Scholar]
  145. Selhub J., Rosenberg I. H. Folate transport in isolated brush border membrane vesicles from rat intestine. J Biol Chem. 1981 May 10;256(9):4489–4493. [PubMed] [Google Scholar]
  146. Sellin J. H., DeSoignie R. Rabbit proximal colon: a distinct transport epithelium. Am J Physiol. 1984 May;246(5 Pt 1):G603–G610. doi: 10.1152/ajpgi.1984.246.5.G603. [DOI] [PubMed] [Google Scholar]
  147. Sellin J. H., DeSoignie R. Short-chain fatty acid absorption in rabbit colon in vitro. Gastroenterology. 1990 Sep;99(3):676–683. doi: 10.1016/0016-5085(90)90954-y. [DOI] [PubMed] [Google Scholar]
  148. Sellin J. H., Desoignie R. Regulation of bicarbonate transport in rabbit ileum: pH stat studies. Am J Physiol. 1989 Oct;257(4 Pt 1):G607–G615. doi: 10.1152/ajpgi.1989.257.4.G607. [DOI] [PubMed] [Google Scholar]
  149. Semrad C. E., Chang E. B. Calcium-mediated cyclic AMP inhibition of Na-H exchange in small intestine. Am J Physiol. 1987 Mar;252(3 Pt 1):C315–C322. doi: 10.1152/ajpcell.1987.252.3.C315. [DOI] [PubMed] [Google Scholar]
  150. Semrad C. E., Cragoe E. J., Jr, Chang E. B. Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor. J Clin Invest. 1990 Aug;86(2):585–591. doi: 10.1172/JCI114748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  151. Sheerin H. E., Field M. Ileal HCO3 secretion: relationship to Na and Cl transport and effect of theophylline. Am J Physiol. 1975 Apr;228(4):1065–1074. doi: 10.1152/ajplegacy.1975.228.4.1065. [DOI] [PubMed] [Google Scholar]
  152. Shiffman M. L., Sugerman H. J., Moore E. W. Human gallbladder mucosal function. Effect of concentration and acidification of bile on cholesterol and calcium solubility. Gastroenterology. 1990 Nov;99(5):1452–1459. doi: 10.1016/0016-5085(90)91175-6. [DOI] [PubMed] [Google Scholar]
  153. Shimada T., Hoshi T. Na+-dependent elevation of the acidic cell surface pH (microclimate pH) of rat jejunal villus cells induced by cyclic nucleotides and phorbol ester: possible mediators of the regulation of the Na+/H+ antiporter. Biochim Biophys Acta. 1988 Jan 22;937(2):328–334. doi: 10.1016/0005-2736(88)90255-6. [DOI] [PubMed] [Google Scholar]
  154. Shull G. E., Lingrel J. B. Molecular cloning of the rat stomach (H+ + K+)-ATPase. J Biol Chem. 1986 Dec 25;261(36):16788–16791. [PubMed] [Google Scholar]
  155. Siskind M. S., McCoy C. E., Chobanian A., Schwartz J. H. Regulation of intracellular calcium by cell pH in vascular smooth muscle cells. Am J Physiol. 1989 Feb;256(2 Pt 1):C234–C240. doi: 10.1152/ajpcell.1989.256.2.C234. [DOI] [PubMed] [Google Scholar]
  156. Sladen G. E., Dawson A. M. Effect of bicarbonate on sodium absorption by the human jejunum. Nature. 1968 Apr 20;218(5138):267–268. doi: 10.1038/218267a0. [DOI] [PubMed] [Google Scholar]
  157. Smith P. L., Cascairo M. A., Sullivan S. K. Sodium dependence of luminal alkalinization by rabbit ileal mucosa. Am J Physiol. 1985 Sep;249(3 Pt 1):G358–G368. doi: 10.1152/ajpgi.1985.249.3.G358. [DOI] [PubMed] [Google Scholar]
  158. Smolka A., Helander H. F., Sachs G. Monoclonal antibodies against gastric H+ + K+ ATPase. Am J Physiol. 1983 Oct;245(4):G589–G596. doi: 10.1152/ajpgi.1983.245.4.G589. [DOI] [PubMed] [Google Scholar]
  159. Soll A. H., Wollin A. Histamine and cyclic AMP in isolated canine parietal cells. Am J Physiol. 1979 Nov;237(5):E444–E450. doi: 10.1152/ajpendo.1979.237.5.E444. [DOI] [PubMed] [Google Scholar]
  160. Strazzabosco M., Mennone A., Boyer J. L. Intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest. 1991 May;87(5):1503–1512. doi: 10.1172/JCI115160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  161. Stuenkel E. L., Machen T. E., Williams J. A. pH regulatory mechanisms in rat pancreatic ductal cells. Am J Physiol. 1988 Jun;254(6 Pt 1):G925–G930. doi: 10.1152/ajpgi.1988.254.6.G925. [DOI] [PubMed] [Google Scholar]
  162. Sullivan S. K., Smith P. L. Bicarbonate secretion by rabbit proximal colon. Am J Physiol. 1986 Oct;251(4 Pt 1):G436–G445. doi: 10.1152/ajpgi.1986.251.4.G436. [DOI] [PubMed] [Google Scholar]
  163. Sundaram U., Knickelbein R. G., Dobbins J. W. Mechanism of intestinal secretion. Effect of serotonin on rabbit ileal crypt and villus cells. J Clin Invest. 1991 Feb;87(2):743–746. doi: 10.1172/JCI115056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  164. Sundaram U., Knickelbein R. G., Dobbins J. W. pH regulation in ileum: Na(+)-H+ and Cl(-)-HCO3- exchange in isolated crypt and villus cells. Am J Physiol. 1991 Mar;260(3 Pt 1):G440–G449. doi: 10.1152/ajpgi.1991.260.3.G440. [DOI] [PubMed] [Google Scholar]
  165. Taylor C. J., Baxter P. S., Hardcastle J., Hardcastle P. T. Failure to induce secretion in jejunal biopsies from children with cystic fibrosis. Gut. 1988 Jul;29(7):957–962. doi: 10.1136/gut.29.7.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  166. Townsley M. C., Machen T. E. Na-HCO3 cotransport in rabbit parietal cells. Am J Physiol. 1989 Sep;257(3 Pt 1):G350–G356. doi: 10.1152/ajpgi.1989.257.3.G350. [DOI] [PubMed] [Google Scholar]
  167. Tse C. M., Ma A. I., Yang V. W., Watson A. J., Levine S., Montrose M. H., Potter J., Sardet C., Pouyssegur J., Donowitz M. Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger. EMBO J. 1991 Aug;10(8):1957–1967. doi: 10.1002/j.1460-2075.1991.tb07725.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  168. Turnamian S. G., Binder H. J. Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon. Am J Physiol. 1990 Mar;258(3 Pt 1):G492–G498. doi: 10.1152/ajpgi.1990.258.3.G492. [DOI] [PubMed] [Google Scholar]
  169. Turnberg L. A., Bieberdorf F. A., Morawski S. G., Fordtran J. S. Interrelationships of chloride, bicarbonate, sodium, and hydrogen transport in the human ileum. J Clin Invest. 1970 Mar;49(3):557–567. doi: 10.1172/JCI106266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Turnberg L. A., Fordtran J. S., Carter N. W., Rector F. C., Jr Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunum. J Clin Invest. 1970 Mar;49(3):548–556. doi: 10.1172/JCI106265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  171. Turnheim K., Hudson R. L., Schultz S. G. Cell Na+ activities and transcellular Na+ absorption by descending colon from normal and Na+-deprived rabbits. Pflugers Arch. 1987 Oct;410(3):279–283. doi: 10.1007/BF00580277. [DOI] [PubMed] [Google Scholar]
  172. Ulrich-Baker M. G., Wang P., Fitzpatrick L., Johnson L. R. Amiloride inhibits rat mucosal ornithine decarboxylase activity and DNA synthesis. Am J Physiol. 1988 Mar;254(3 Pt 1):G408–G415. doi: 10.1152/ajpgi.1988.254.3.G408. [DOI] [PubMed] [Google Scholar]
  173. Urushidani T., Hanzel D. K., Forte J. G. Protein phosphorylation associated with stimulation of rabbit gastric glands. Biochim Biophys Acta. 1987 Sep 14;930(2):209–219. doi: 10.1016/0167-4889(87)90033-4. [DOI] [PubMed] [Google Scholar]
  174. Wallmark B., Larsson H., Humble L. The relationship between gastric acid secretion and gastric H+,K+-ATPase activity. J Biol Chem. 1985 Nov 5;260(25):13681–13684. [PubMed] [Google Scholar]
  175. Watson A. J., Levine S., Donowitz M., Montrose M. H. Kinetics and regulation of a polarized Na(+)-H+ exchanger from Caco-2 cells, a human intestinal cell line. Am J Physiol. 1991 Aug;261(2 Pt 1):G229–G238. doi: 10.1152/ajpgi.1991.261.2.G229. [DOI] [PubMed] [Google Scholar]
  176. Welsh M. J. Electrolyte transport by airway epithelia. Physiol Rev. 1987 Oct;67(4):1143–1184. doi: 10.1152/physrev.1987.67.4.1143. [DOI] [PubMed] [Google Scholar]
  177. Welsh M. J., Liedtke C. M. Chloride and potassium channels in cystic fibrosis airway epithelia. 1986 Jul 31-Aug 6Nature. 322(6078):467–470. doi: 10.1038/322467a0. [DOI] [PubMed] [Google Scholar]
  178. Welsh M. J., Smith P. L., Fromm M., Frizzell R. A. Crypts are the site of intestinal fluid and electrolyte secretion. Science. 1982 Dec 17;218(4578):1219–1221. doi: 10.1126/science.6293054. [DOI] [PubMed] [Google Scholar]
  179. Wenzl E., Sjaastad M. D., Weintraub W. H., Machen T. E. Intracellular pH regulation in IEC-6 cells, a cryptlike intestinal cell line. Am J Physiol. 1989 Nov;257(5 Pt 1):G732–G740. doi: 10.1152/ajpgi.1989.257.5.G732. [DOI] [PubMed] [Google Scholar]
  180. Wolfe M. M., Soll A. H. The physiology of gastric acid secretion. N Engl J Med. 1988 Dec 29;319(26):1707–1715. doi: 10.1056/NEJM198812293192605. [DOI] [PubMed] [Google Scholar]
  181. Wolosin J. M., Forte J. G. Stimulation of oxyntic cell triggers K+ and Cl- conductances in apical H+-K+-ATPase membrane. Am J Physiol. 1984 May;246(5 Pt 1):C537–C545. doi: 10.1152/ajpcell.1984.246.5.C537. [DOI] [PubMed] [Google Scholar]
  182. Yoon Y. B., Hagey L. R., Hofmann A. F., Gurantz D., Michelotti E. L., Steinbach J. H. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology. 1986 Apr;90(4):837–852. doi: 10.1016/0016-5085(86)90859-0. [DOI] [PubMed] [Google Scholar]
  183. de Caestecker J. S., Jazrawi R. P., Petroni M. L., Northfield T. C. Ursodeoxycholic acid in chronic liver disease. Gut. 1991 Sep;32(9):1061–1065. doi: 10.1136/gut.32.9.1061. [DOI] [PMC free article] [PubMed] [Google Scholar]

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