Skip to main content
NCBI home page
Gut logoLink to Gut
. 1992 Sep;33(9):1166–1169. doi: 10.1136/gut.33.9.1166

Use of cimetidine and other peptic ulcer drugs in Denmark 1977-1990 with analysis of the risk of gastric cancer among cimetidine users.

H Møller 1, A Nissen 1, J Mosbech 1
PMCID: PMC1379479  PMID: 1358764

Abstract

The prevalence of use of peptic ulcer drugs in the Danish population is described at two points in time using registrations of applications for reimbursement. In 1977-81, the prevalence of use of cimetidine was 0.4% in men and 0.2% in women. In 1989-90, the prevalence of use of peptic ulcer drugs was 1.3% in men and 1.2% in women. The increase in prevalence was apparent in all age groups, but most pronounced at relatively old age. The median age of users increased from 55 years in 1977-81 to 63 years in 1989-90. The data indicated that a third of those who used peptic ulcer drugs in 1977-81 also used these drugs in 1989-90, conditional on surviving this period. The probability of becoming a long term user was highest for those who were 50-69 years in 1977-81. The incidence of gastric cancer was investigated in the cohort of persons who used cimetidine in 1977-81. An excess risk of gastric cancer was apparent in the first years after start of cimetidine use. This is thought to reflect a selection bias. Significantly increased incidence was also observed in women seven years or longer after start of cimetidine use (RR = 4.7; 95% CI: 1.7-10.3). This estimate was, however, based on only six cases, and a similar pattern was not observed in men.

Full text

PDF
1166

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brinton L. A., Gridley G., Hrubec Z., Hoover R., Fraumeni J. F., Jr Cancer risk following pernicious anaemia. Br J Cancer. 1989 May;59(5):810–813. doi: 10.1038/bjc.1989.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Colin-Jones D. G., Langman M. J., Lawson D. H., Vessey M. P. Cimetidine and gastric cancer: preliminary report from post-marketing surveillance study. Br Med J (Clin Res Ed) 1982 Nov 6;285(6351):1311–1313. doi: 10.1136/bmj.285.6351.1311. [DOI] [PubMed] [Google Scholar]
  3. Elder J. B., Ganguli P. C., Gillespie I. E. Cimetidine and gastric cancer. Lancet. 1979 May 12;1(8124):1005–1006. doi: 10.1016/s0140-6736(79)92757-0. [DOI] [PubMed] [Google Scholar]
  4. Gormsen M., Jensen K. S., Matzen P., Bonnevie O. Grundlaget for anvendelse af ulcusmedicin i almen praksis. Ugeskr Laeger. 1988 Sep 12;150(37):2169–2171. [PubMed] [Google Scholar]
  5. Griffin M. R., Piper J. M., Daugherty J. R., Snowden M., Ray W. A. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med. 1991 Feb 15;114(4):257–263. doi: 10.7326/0003-4819-114-4-257. [DOI] [PubMed] [Google Scholar]
  6. Hallissey M. T., Allum W. H., Jewkes A. J., Ellis D. J., Fielding J. W. Early detection of gastric cancer. BMJ. 1990 Sep 15;301(6751):513–515. doi: 10.1136/bmj.301.6751.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heatley R. V., Rathbone B. J. Dyspepsia: a dilemma for doctors? Lancet. 1987 Oct 3;2(8562):779–782. doi: 10.1016/s0140-6736(87)92509-8. [DOI] [PubMed] [Google Scholar]
  8. La Vecchia C., Negri E., D'Avanzo B., Franceschi S. Histamine-2-receptor antagonists and gastric cancer risk. Lancet. 1990 Aug 11;336(8711):355–357. doi: 10.1016/0140-6736(90)91888-h. [DOI] [PubMed] [Google Scholar]
  9. Langman M. J. Antisecretory drugs and gastric cancer. Br Med J (Clin Res Ed) 1985 Jun 22;290(6485):1850–1852. doi: 10.1136/bmj.290.6485.1850. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Møller H., Lindvig K., Klefter R., Mosbech J., Møller Jensen O. Cancer occurrence in a cohort of patients treated with cimetidine. Gut. 1989 Nov;30(11):1558–1562. doi: 10.1136/gut.30.11.1558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Møller H., Toftgaard C. Cancer occurrence in a cohort of patients surgically treated for peptic ulcer. Gut. 1991 Jul;32(7):740–744. doi: 10.1136/gut.32.7.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nissen A. Mavesårspraeparater: Forbrug, priser og tilskud før og efter den 27.3.1989. Ugeskr Laeger. 1991 May 13;153(20):1436–1437. [PubMed] [Google Scholar]
  13. Nyrén O., Adami H. O., Bates S., Bergström R., Gustavsson S., Löf L., Nyberg A. Absence of therapeutic benefit from antacids or cimetidine in non-ulcer dyspepsia. N Engl J Med. 1986 Feb 6;314(6):339–343. doi: 10.1056/NEJM198602063140603. [DOI] [PubMed] [Google Scholar]
  14. Schumacher M. C., Jick S. S., Jick H., Feld A. D. Cimetidine use and gastric cancer. Epidemiology. 1990 May;1(3):251–254. doi: 10.1097/00001648-199005000-00012. [DOI] [PubMed] [Google Scholar]
  15. Sharma B. K., Santana I. A., Wood E. C., Walt R. P., Pereira M., Noone P., Smith P. L., Walters C. L., Pounder R. E. Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole. Br Med J (Clin Res Ed) 1984 Sep 22;289(6447):717–719. doi: 10.1136/bmj.289.6447.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sipponen P., Kekki M., Haapakoski J., Ihamäki T., Siurala M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer. 1985 Feb 15;35(2):173–177. doi: 10.1002/ijc.2910350206. [DOI] [PubMed] [Google Scholar]
  17. Stockbrugger R. W., Cotton P. B., Eugenides N., Bartholomew B. A., Hill M. J., Walters C. L. Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetidine treatment. Gut. 1982 Dec;23(12):1048–1054. doi: 10.1136/gut.23.12.1048. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Taylor R. H., Menzies-Gow N., Lovell D., La Brooy S. J., Misiewicz J. J. Misleading response of malignant gastric ulcers to cimetidine. Lancet. 1978 Apr 1;1(8066):686–688. doi: 10.1016/s0140-6736(78)90799-7. [DOI] [PubMed] [Google Scholar]
  19. Wade A. G., Rowley-Jones D. Long term management of duodenal ulcer in general practice: how best to use cimetidine? Br Med J (Clin Res Ed) 1988 Apr 2;296(6627):971–974. doi: 10.1136/bmj.296.6627.971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Watt P. C., Patterson C. C., Kennedy T. L. Late mortality after vagotomy and drainage for duodenal ulcer. Br Med J (Clin Res Ed) 1984 May 5;288(6427):1335–1338. doi: 10.1136/bmj.288.6427.1335. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES