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. 1992 Sep;33(9):1246–1248. doi: 10.1136/gut.33.9.1246

Effects of alpha-glucosidase inhibitors on mouth to caecum transit time in humans.

S D Ladas 1, A Frydas 1, A Papadopoulos 1, S A Raptis 1
PMCID: PMC1379495  PMID: 1427379

Abstract

The alpha-glucosidase inhibitors acarbose and miglitol have been successfully used to control postprandial hyperglycaemia in diabetics. They probably work by slowing carbohydrate digestion and absorption, but their effect on mouth to caecum transit time has not been studied. The effect acarbose (100 mg), miglitol (100 mg), and placebo on mouth to caecum transit time (380 kcal breakfast with 20 g of lactulose) was investigated in 18 normal volunteers using breath hydrogen analysis. Both miglitol and acarbose significantly increased breath hydrogen excretion (F2,34 = 6.31, p = 0.005) and shortened the mouth to caecum transit time (F2,34 = 3.49, p = 0.04) after breakfast compared with placebo. There was a significant negative correlation between breath hydrogen excretion and mouth to caecum transit time suggesting that with shorter transit times significantly more carbohydrates were spilled into the colon. These results indicate that alpha-glucosidase inhibitors accelerate mouth to caecum transit time by inducing carbohydrate malabsorption.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bond J. H., Levitt M. D. Use of breath hydrogen (H2) to quantitate small bowel transit time following partial gastrectomy. J Lab Clin Med. 1977 Jul;90(1):30–36. [PubMed] [Google Scholar]
  2. Dimitriadis G., Hatziagelaki E., Ladas S., Linos A., Hillebrand I., Raptis S. Effects of prolonged administration of two new alpha-glucosidase inhibitors on blood glucose control, insulin requirements and breath hydrogen excretion in patients with insulin-dependent diabetes mellitus. Eur J Clin Invest. 1988 Feb;18(1):33–38. doi: 10.1111/j.1365-2362.1988.tb01162.x. [DOI] [PubMed] [Google Scholar]
  3. Dimitriadis G., Raptis S., Raptis A., Hatziagelaki E., Mitrakou A., Halvatsiotis P., Ladas S., Hillebrand I. Effects of two new alpha-glucosidase inhibitors on glycemic control in patients with insulin-dependent diabetes mellitus. Klin Wochenschr. 1986 May 2;64(9):405–410. doi: 10.1007/BF01727525. [DOI] [PubMed] [Google Scholar]
  4. Jenkins D. J., Taylor R. H., Goff D. V., Fielden H., Misiewicz J. J., Sarson D. L., Bloom S. R., Alberti K. G. Scope and specificity of acarbose in slowing carbohydrate absorption in man. Diabetes. 1981 Nov;30(11):951–954. doi: 10.2337/diab.30.11.951. [DOI] [PubMed] [Google Scholar]
  5. Ladas S. D., Latoufis C., Giannopoulou H., Hatziioannou J., Raptis S. A. Reproducible lactulose hydrogen breath test as a measure of mouth-to-cecum transit time. Dig Dis Sci. 1989 Jun;34(6):919–924. doi: 10.1007/BF01540279. [DOI] [PubMed] [Google Scholar]
  6. Ladas S., Papanikos J., Arapakis G. Lactose malabsorption in Greek adults: correlation of small bowel transit time with the severity of lactose intolerance. Gut. 1982 Nov;23(11):968–973. doi: 10.1136/gut.23.11.968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lawson M., Kern F., Jr, Everson G. T. Gastrointestinal transit time in human pregnancy: prolongation in the second and third trimesters followed by postpartum normalization. Gastroenterology. 1985 Nov;89(5):996–999. doi: 10.1016/0016-5085(85)90199-4. [DOI] [PubMed] [Google Scholar]
  8. McNeil N. I., Cummings J. H., James W. P. Short chain fatty acid absorption by the human large intestine. Gut. 1978 Sep;19(9):819–822. doi: 10.1136/gut.19.9.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McNeil N. I. The contribution of the large intestine to energy supplies in man. Am J Clin Nutr. 1984 Feb;39(2):338–342. doi: 10.1093/ajcn/39.2.338. [DOI] [PubMed] [Google Scholar]
  10. Metz G., Gassull M. A., Leeds A. R., Blendis L. M., Jenkins D. J. A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling. Clin Sci Mol Med. 1976 Mar;50(3):237–240. doi: 10.1042/cs0500237. [DOI] [PubMed] [Google Scholar]
  11. Puls W., Keup U., Krause H. P., Thomas G., Hoffmeister F. Glucosidase inhibition. A new approach to the treatment of diabetes, obesity, and hyperlipoproteinaemia. Naturwissenschaften. 1977 Oct;64(10):536–537. doi: 10.1007/BF00483562. [DOI] [PubMed] [Google Scholar]
  12. Royall D., Wolever T. M., Jeejeebhoy K. N. Clinical significance of colonic fermentation. Am J Gastroenterol. 1990 Oct;85(10):1307–1312. [PubMed] [Google Scholar]
  13. Rumessen J. J., Hamberg O., Gudmand-Høyer E. Influence of orocaecal transit time on hydrogen excretion after carbohydrate malabsorption. Gut. 1989 Jun;30(6):811–814. doi: 10.1136/gut.30.6.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ruppin H., Hagel J., Feuerbach W., Schutt H., Pichl J., Hillebrand I., Bloom S., Domschke W. Fate and effects of the alpha-glucosidase inhibitor acarbose in humans. An intestinal slow-marker perfusion study. Gastroenterology. 1988 Jul;95(1):93–99. doi: 10.1016/0016-5085(88)90295-8. [DOI] [PubMed] [Google Scholar]
  15. Sachse G., Willms B. Effect of the alpha-glucosidase-inhibitor BAY-g-5421 on blood glucose control of sulphonylurea-treated diabetics and insulin-treated diabetics. Diabetologia. 1979 Nov;17(5):287–290. doi: 10.1007/BF01235884. [DOI] [PubMed] [Google Scholar]
  16. Scheppach W., Fabian C., Ahrens F., Spengler M., Kasper H. Effect of starch malabsorption on colonic function and metabolism in humans. Gastroenterology. 1988 Dec;95(6):1549–1555. doi: 10.1016/s0016-5085(88)80076-3. [DOI] [PubMed] [Google Scholar]
  17. Walton R. J., Sherif I. T., Noy G. A., Alberti K. G. Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor. Br Med J. 1979 Jan 27;1(6158):220–221. doi: 10.1136/bmj.1.6158.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Welsh J. D., Payne D. L., Manion C., Morrison R. D., Nichols M. A. Interval sampling of breath hydrogen (H2) as an index of lactose malabsorption in lactase-deficient subjects. Dig Dis Sci. 1981 Aug;26(8):681–685. doi: 10.1007/BF01316855. [DOI] [PubMed] [Google Scholar]

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