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. 1992 Oct;33(10):1433–1435. doi: 10.1136/gut.33.10.1433

Different DNA changes in primary and recurrent hepatocellular carcinoma.

S F Ding 1, R P Jalleh 1, C B Wood 1, L Bowles 1, J D Delhanty 1, J Dooley 1, N A Habib 1
PMCID: PMC1379621  PMID: 1359992

Abstract

DNA restriction fragment length polymorphism analysis was carried out on a primary and recurrent hepatocellular carcinoma in a hepatitis B virus negative patient. For the primary tumour, allele losses were found on the short arm of chromosome 17 (probe: p144-D6, 17p13) and the long arm of chromosome 5 with the probe Lambda MS8 (5q35-qter); other probes showed either no allele loss or a non-informative pattern. The recurrent cancer also showed allele loss with p144-D6, but not with Lambda MS8. In addition, the recurrent tumour had allele losses with Lambda MS43 (12q24.3-qter), pYNZ22 (17p13), and DNA rearrangement revealed by the probe Lambda MS32 (1q42-43), a pattern not seen in the primary lesion. These results indicate that the second hepatocellular carcinoma was of independent clonality and probably represents a de novo neoplasm rather than a recurrence.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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