Abstract
1 Neuropathological changes in experimental animals have been observed with vigabatrin treatment in mice, rats and dogs.
2 These changes have comprised intramyelinic oedema which is reversible on cessation of treatment.
3 In human studies so far, no intramyelinic oedema has been noted. It is not clear whether humans will show the neurotoxicity observed in animals; close monitoring of patients is indicated.
Keywords: vigabatrin, neuropathology, intra-myelinic oedema
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