Abstract
1 The purpose of this study was to evaluate the efficacy of vigabatrin in relation to the seizure type.
2 A review of the literature concerning the efficacy of vigabatrin in clinical trials was performed.
3 To date, vigabatrin has been used in a small number of patients with generalized seizures: in this group no significant effect was noted.
4 Vigabatrin was also given to a large number of patients with complex partial seizures: in this group vigabatrin produced a greater than 50% decrease in seizure frequency in almost 50% of patients included.
5 This review provides evidence that vigabatrin is effective in the treatment of complex partial seizures: patients with only one seizure type, low seizure frequency and unifocal EEG abnormalities are particularly expected to respond.
6 This implies that patients with complex partial seizures do not constitute an homogeneous group and that various parameters should be considered in the evaluation of the response to treatment.
Keywords: vigabatrin, seizure type, generalized seizures, complex partial seizures
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Selected References
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