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. 1989 Jan;27(1):83–87. doi: 10.1111/j.1365-2125.1989.tb05338.x

A comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow.

N C Sambol 1, R A Upton 1, A N Chremos 1, E T Lin 1, R L Williams 1
PMCID: PMC1379708  PMID: 2565119

Abstract

The H2-receptor antagonist cimetidine has been reported to decrease the hepatic clearance of numerous drugs by inhibiting cytochrome P-450 metabolism, decreasing liver blood flow or both. In this open-label, randomized crossover study we determined whether therapeutic doses of famotidine, a newer H2-receptor antagonist, has similar effects. Ten healthy subjects received single doses of both phenytoin 100 mg orally and indocyanine green intravenously without other treatment, and then again during treatment with famotidine or cimetidine. After a drug-free period, this sequence was repeated with the alternate H2-receptor antagonist. Cimetidine decreased the plasma clearance of phenytoin by 16% +/- 14% (mean +/- s.d.), but was not found to have a significant influence on phenytoin volume of distribution or terminal elimination rate constant nor on blood clearance of indocyanine green. Famotidine was not found to alter either phenytoin or indocyanine green kinetics.

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Selected References

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