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. 1989 Apr;27(4):423–428. doi: 10.1111/j.1365-2125.1989.tb05389.x

Variable metabolism of pinacidil: lack of correlation with the debrisoquine and trimethylamine C- and N-oxidative polymorphisms.

R Ayesh 1, M Al-Waiz 1, A McBurney 1, S C Mitchell 1, J R Idle 1, J W Ward 1, R L Smith 1
PMCID: PMC1379720  PMID: 2719898

Abstract

1. The urinary excretion of pinacidil and its N-oxide in man was found to vary over a five-fold range. 2. Studies in individuals with inherited deficiencies for C-hydroxylation (debrisoquine type) and trimethylamine N-oxidation showed that the N-oxidation of pinacidil did not co-segregate with these oxidative polymorphisms. 3. It is concluded that the variable N-oxidation of pinacidil is most likely to be due to variations in the activity of the P-450 isozymes rather than in the microsomal flavoprotein containing mixed-function amine oxidase of Ziegler which is considered to be responsible for the N-oxidation of trimethylamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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