Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1989 Feb;27(2):165–171. doi: 10.1111/j.1365-2125.1989.tb05347.x

Effect of infused adenosine on cardiac output and systemic resistance in normal subjects.

A Bush 1, C M Busst 1, B Clarke 1, P J Barnes 1
PMCID: PMC1379776  PMID: 2713212

Abstract

1. The purine nucleoside adenosine relaxes smooth muscle in vitro and is a vasodilator in animals, but its effects on cardiac output and systemic vascular resistance have not been measured in normal conscious human subjects. 2. We have studied the effects of infused adenosine in doses of 0.005, 0.03 and 0.07 mg kg-1 min-1 on pulmonary blood flow and systemic vascular resistance in eight healthy volunteers, using a non-invasive, inert gas method and mass spectrometry. 3. At a dose of 0.07 mg kg-1 min-1, there was a rise in effective pulmonary blood flow (which is approximately equivalent to cardiac output) of 0.52 +/- 0.08 l min-1 m-2 (mean +/- s.e. mean) and a fall in estimated systemic vascular resistance of 357 +/- 44 dyn s cm-5. Despite this marked systemic vasodilation, there was no significant change in mean heart rate. 4. The effects of this dose of adenosine were maximal 2 min after starting the infusion, and had disappeared within 5 min of stopping it. 5. Adenosine may be therapeutically useful in the reduction of left ventricular afterload, where the absence of reflex tachycardia may be advantageous. We suggest that adenosine in doses of 0.03 mg kg-1 min-1 should be evaluated as a selective pulmonary vasodilator.

Full text

PDF
165

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bakhle Y. S., Chelliah R. Metabolism and uptake of adenosine in rat isolated lung and its inhibition. Br J Pharmacol. 1983 Jun;79(2):509–515. doi: 10.1111/j.1476-5381.1983.tb11025.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berne R. M., DiMarco J. P., Belardinelli L. Dromotropic effects of adenosine and adenosine antagonists in the treatment of cardiac arrhythmias involving the atrioventricular node. Circulation. 1984 Jun;69(6):1195–1197. doi: 10.1161/01.cir.69.6.1195. [DOI] [PubMed] [Google Scholar]
  3. Borow K. M., Newburger J. W. Noninvasive estimation of central aortic pressure using the oscillometric method for analyzing systemic artery pulsatile blood flow: comparative study of indirect systolic, diastolic, and mean brachial artery pressure with simultaneous direct ascending aortic pressure measurements. Am Heart J. 1982 May;103(5):879–886. doi: 10.1016/0002-8703(82)90403-3. [DOI] [PubMed] [Google Scholar]
  4. Bush A., Busst C. M., Millar A., Syrett N. Time course of the effects of epoprostenol on effective pulmonary blood flow in normal volunteers. Br J Clin Pharmacol. 1988 Mar;25(3):341–348. doi: 10.1111/j.1365-2125.1988.tb03312.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clarke B., Till J., Rowland E., Ward D. E., Barnes P. J., Shinebourne E. A. Rapid and safe termination of supraventricular tachycardia in children by adenosine. Lancet. 1987 Feb 7;1(8528):299–301. doi: 10.1016/s0140-6736(87)92027-7. [DOI] [PubMed] [Google Scholar]
  6. Conradson T. B., Dixon C. M., Clarke B., Barnes P. J. Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole. Acta Physiol Scand. 1987 Mar;129(3):387–391. doi: 10.1111/j.1748-1716.1987.tb08082.x. [DOI] [PubMed] [Google Scholar]
  7. Davidson F. F., Glazier J. B., Murray J. F. The components of the alveolar-arterial oxygen tension difference in normal subjects and in patients with pneumonia and obstructive lung disease. Am J Med. 1972 Jun;52(6):754–762. doi: 10.1016/0002-9343(72)90081-2. [DOI] [PubMed] [Google Scholar]
  8. Denison D. M., Waller J. F. Interpreting the results of regional single-breath studies from the patient's point of view. Bull Eur Physiopathol Respir. 1982 Mar-Apr;18(2):339–351. [PubMed] [Google Scholar]
  9. Fox I. H., Kelley W. N. The role of adenosine and 2'-deoxyadenosine in mammalian cells. Annu Rev Biochem. 1978;47:655–686. doi: 10.1146/annurev.bi.47.070178.003255. [DOI] [PubMed] [Google Scholar]
  10. Fuller R. W., Maxwell D. L., Conradson T. B., Dixon C. M., Barnes P. J. Circulatory and respiratory effects of infused adenosine in conscious man. Br J Clin Pharmacol. 1987 Sep;24(3):309–317. doi: 10.1111/j.1365-2125.1987.tb03174.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hellewell P. G., Pearson J. D. Metabolism of circulating adenosine by the porcine isolated perfused lung. Circ Res. 1983 Jul;53(1):1–7. doi: 10.1161/01.res.53.1.1. [DOI] [PubMed] [Google Scholar]
  12. Herlihy J. T., Bockman E. L., Berne R. M., Rubio R. Adenosine relaxation of isolated vascular smooth muscle. Am J Physiol. 1976 May;230(5):1239–1243. doi: 10.1152/ajplegacy.1976.230.5.1239. [DOI] [PubMed] [Google Scholar]
  13. Klabunde R. E. Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol. 1983 Sep 16;93(1-2):21–26. doi: 10.1016/0014-2999(83)90026-2. [DOI] [PubMed] [Google Scholar]
  14. Lagerkranser M., Irestedt L., Sollevi A., Andreen M. Central and splanchnic hemodynamics in the dog during controlled hypotension with adenosine. Anesthesiology. 1984 Jun;60(6):547–552. doi: 10.1097/00000542-198406000-00005. [DOI] [PubMed] [Google Scholar]
  15. Packer M., Greenberg B., Massie B., Dash H. Deleterious effects of hydralazine in patients with pulmonary hypertension. N Engl J Med. 1982 Jun 3;306(22):1326–1331. doi: 10.1056/NEJM198206033062203. [DOI] [PubMed] [Google Scholar]
  16. Silver P. J., Walus K., DiSalvo J. Adenosine-mediated relaxation and activation of cyclic AMP-dependent protein kinase in coronary arterial smooth muscle. J Pharmacol Exp Ther. 1984 Feb;228(2):342–347. [PubMed] [Google Scholar]
  17. Sollevi A. Cardiovascular effects of adenosine in man; possible clinical implications. Prog Neurobiol. 1986;27(4):319–349. doi: 10.1016/0301-0082(86)90005-5. [DOI] [PubMed] [Google Scholar]
  18. Sollevi A., Lagerkranser M., Irestedt L., Gordon E., Lindquist C. Controlled hypotension with adenosine in cerebral aneurysm surgery. Anesthesiology. 1984 Oct;61(4):400–405. doi: 10.1097/00000542-198410000-00007. [DOI] [PubMed] [Google Scholar]
  19. Sollevi A., Torssell L., Fredholm B. B., Settergren G., Blombäck M. Adenosine spares platelets during cardiopulmonary bypass in man without causing systemic vasodilatation. Scand J Thorac Cardiovasc Surg. 1985;19(2):155–159. doi: 10.3109/14017438509102711. [DOI] [PubMed] [Google Scholar]
  20. Watt A. H., Penny W. J., Singh H., Routledge P. A., Henderson A. H. Adenosine causes transient dilatation of coronary arteries in man. Br J Clin Pharmacol. 1987 Nov;24(5):665–668. doi: 10.1111/j.1365-2125.1987.tb03227.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES