Abstract
1. The pharmacokinetics of cyclosporin were studied in six renal transplant patients, following intravenous administration of 5 mg kg-1 infused over 3, 6 and 24 h. 2. Plasma, separated at 37 degrees C, was analysed for cyclosporin by h.p.l.c. 3. The data were described by a biexponential disposition model. 4. None of the disposition parameters (clearance, initial volume of distribution, half-lives) changed with the duration of infusion.
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Selected References
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- Boxenbaum H. G., Riegelman S., Elashoff R. M. Statistical estimations in pharmacokinetics. J Pharmacokinet Biopharm. 1974 Apr;2(2):123–148. doi: 10.1007/BF01061504. [DOI] [PubMed] [Google Scholar]
- Gupta S. K., Legg B., Solomon L. R., Johnson R. W., Rowland M. Pharmacokinetics of cyclosporin: influence of rate of constant intravenous infusion in renal transplant patients. Br J Clin Pharmacol. 1987 Oct;24(4):519–526. doi: 10.1111/j.1365-2125.1987.tb03206.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Legg B., Rowland M. Saturable binding of cyclosporin A to erythrocytes: estimation of binding parameters in renal transplant patients and implications for bioavailability assessment. Pharm Res. 1988 Feb;5(2):80–85. doi: 10.1023/a:1015932032609. [DOI] [PubMed] [Google Scholar]
- Ptachcinski R. J., Venkataramanan R., Burckart G. J. Clinical pharmacokinetics of cyclosporin. Clin Pharmacokinet. 1986 Mar-Apr;11(2):107–132. doi: 10.2165/00003088-198611020-00002. [DOI] [PubMed] [Google Scholar]
- Ptachcinski R. J., Venkataramanan R., Rosenthal J. T., Burckart G. J., Taylor R. J., Hakala T. R. Cyclosporine kinetics in renal transplantation. Clin Pharmacol Ther. 1985 Sep;38(3):296–300. doi: 10.1038/clpt.1985.174. [DOI] [PubMed] [Google Scholar]
- Yee G. C., Kennedy M. S., Storb R., Thomas E. D. Pharmacokinetics of intravenous cyclosporine in bone marrow transplant patients. Comparison of two assay methods. Transplantation. 1984 Nov;38(5):511–513. doi: 10.1097/00007890-198411000-00014. [DOI] [PubMed] [Google Scholar]