Abstract
1. Thirty-eight patients with mild to moderate essential hypertension (seated diastolic 95-110 mm Hg) were randomized double-blind to treatment with either zofenopril (n = 19) or hydrochlorothiazide (n = 19) over a period of 12 weeks. 2. Office blood pressure, heart rate, side effects and metabolic changes were assessed at the end of the run-in period on placebo and after 4, 8, 12 weeks treatment at the same time, 22-24 h after the last dosing. Ambulatory recordings over 14 h (8 h to 22 h) were performed at the end of placebo period and after active treatment for 12 weeks. 3. The two regimes reduced office blood pressures equally with minimal additional effect seen on increasing the dose. Both zofenopril and hydrochlorothiazide lowered average baseline ambulatory blood pressure, but zofenopril had greater efficacy in reducing BP during some working hours. 4. Adverse reactions were mild and transient with both drugs. There were no significant changes in laboratory values. 5. Thus hydrochlorothiazide and zofenopril given once daily at low dosage both reduce office and ambulatory blood pressures and are well tolerated.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baumgart P., Tenschert W., Vetter H. Efficacy of low dose captopril once daily in diuretic resistant hypertension. Postgrad Med J. 1986;62 (Suppl 1):127–130. [PubMed] [Google Scholar]
- Devereux R. B., Pickering T. G., Harshfield G. A., Kleinert H. D., Denby L., Clark L., Pregibon D., Jason M., Kleiner B., Borer J. S. Left ventricular hypertrophy in patients with hypertension: importance of blood pressure response to regularly recurring stress. Circulation. 1983 Sep;68(3):470–476. doi: 10.1161/01.cir.68.3.470. [DOI] [PubMed] [Google Scholar]
- Ferguson R. K., Vlasses P. H., Swanson B. N., Mojaverian P., Hichens M., Irvin J. D., Huber P. B. Effects of enalapril, a new converting enzyme inhibitor, in hypertension. Clin Pharmacol Ther. 1982 Jul;32(1):48–53. doi: 10.1038/clpt.1982.125. [DOI] [PubMed] [Google Scholar]
- Kaplan N. M. Benefits of low vs high dosages of diuretics. Clin Ther. 1984;6(2):198–204. [PubMed] [Google Scholar]
- Mackaness G. B. The future of angiotensin-converting enzyme inhibitors. J Cardiovasc Pharmacol. 1985;7 (Suppl 1):S30–S34. doi: 10.1097/00005344-198507001-00007. [DOI] [PubMed] [Google Scholar]
- McVeigh G., Galloway D., Johnston D. The case for low dose diuretics in hypertension: comparison of low and conventional doses of cyclopenthiazide. BMJ. 1988 Jul 9;297(6641):95–98. doi: 10.1136/bmj.297.6641.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meijer J. L., Ardesch H. G., van Rooijen J. C., de Bruijn J. H. Low dose captopril twice daily lowers blood pressure without disturbance of the normal circadian rhythm. Postgrad Med J. 1986;62 (Suppl 1):101–105. [PubMed] [Google Scholar]
- Parati G., Pomidossi G., Albini F., Malaspina D., Mancia G. Relationship of 24-hour blood pressure mean and variability to severity of target-organ damage in hypertension. J Hypertens. 1987 Feb;5(1):93–98. doi: 10.1097/00004872-198702000-00013. [DOI] [PubMed] [Google Scholar]
- Perloff D., Sokolow M., Cowan R. The prognostic value of ambulatory blood pressures. JAMA. 1983 May 27;249(20):2792–2798. [PubMed] [Google Scholar]
- Pickering T. G., Harshfield G. A., Devereux R. B., Laragh J. H. What is the role of ambulatory blood pressure monitoring in the management of hypertensive patients? Hypertension. 1985 Mar-Apr;7(2):171–177. doi: 10.1161/01.hyp.7.2.171. [DOI] [PubMed] [Google Scholar]