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. 1989 Mar;27(3):391–395. doi: 10.1111/j.1365-2125.1989.tb05383.x

Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects.

N Brion 1, E Naline 1, D Beaumont 1, M Pays 1, C Advenier 1
PMCID: PMC1379841  PMID: 2497767

Abstract

The pharmacokinetics of oral theophylline (250 mg) and the production of its metabolites (3-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid) were studied before and after the administration of oral terfenadine (120 mg twice daily for 16 days) in 10 healthy volunteers. Comparison of volumes of distribution, elimination half-lives, areas under the plasma concentration-time curves, plasma clearance of theophylline and elimination of theophylline metabolites indicated that terfenadine had no significant effect on theophylline pharmacokinetics and metabolism.

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Selected References

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