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. 1989 Mar;27(3):391–395. doi: 10.1111/j.1365-2125.1989.tb05383.x

Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects.

N Brion 1, E Naline 1, D Beaumont 1, M Pays 1, C Advenier 1
PMCID: PMC1379841  PMID: 2497767

Abstract

The pharmacokinetics of oral theophylline (250 mg) and the production of its metabolites (3-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid) were studied before and after the administration of oral terfenadine (120 mg twice daily for 16 days) in 10 healthy volunteers. Comparison of volumes of distribution, elimination half-lives, areas under the plasma concentration-time curves, plasma clearance of theophylline and elimination of theophylline metabolites indicated that terfenadine had no significant effect on theophylline pharmacokinetics and metabolism.

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Selected References

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  1. Badier M., Beaumont D., Orehek J. Attenuation of hyperventilation-induced bronchospasm by terfenadine: a new antihistamine. J Allergy Clin Immunol. 1988 Feb;81(2):437–440. doi: 10.1016/0091-6749(88)90913-x. [DOI] [PubMed] [Google Scholar]
  2. Brandon M. L., Weiner M. Clinical investigation of terfenadine, a non-sedating antihistamine. Ann Allergy. 1980 Feb;44(2):71–75. [PubMed] [Google Scholar]
  3. Campbell M. E., Grant D. M., Inaba T., Kalow W. Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes. Drug Metab Dispos. 1987 Mar-Apr;15(2):237–249. [PubMed] [Google Scholar]
  4. Chan T. B., Shelton D. M., Eiser N. M. Effect of an oral H1-receptor antagonist, terfenadine, on antigen-induced asthma. Br J Dis Chest. 1986 Oct;80(4):375–384. doi: 10.1016/0007-0971(86)90091-4. [DOI] [PubMed] [Google Scholar]
  5. Eiser N. M., Mills J., Snashall P. D., Guz A. The role of histamine receptors in asthma. Clin Sci (Lond) 1981 Apr;60(4):363–370. doi: 10.1042/cs0600363. [DOI] [PubMed] [Google Scholar]
  6. Grygiel J. J., Birkett D. J. Cigarette smoking and theophylline clearance and metabolism. Clin Pharmacol Ther. 1981 Oct;30(4):491–496. doi: 10.1038/clpt.1981.193. [DOI] [PubMed] [Google Scholar]
  7. Grygiel J. J., Miners J. O., Drew R., Birkett D. J. Differential effects of cimetidine on theophylline metabolic pathways. Eur J Clin Pharmacol. 1984;26(3):335–340. doi: 10.1007/BF00548764. [DOI] [PubMed] [Google Scholar]
  8. Miners J. O., Wing L. M., Lillywhite K. J., Robson R. A. Selectivity and dose-dependency of the inhibitory effect of propranolol on theophylline metabolism in man. Br J Clin Pharmacol. 1985 Sep;20(3):219–223. doi: 10.1111/j.1365-2125.1985.tb05064.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Moser L., Hüther K. J., Koch-Weser J., Lundt P. V. Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. Eur J Clin Pharmacol. 1978 Dec 18;14(6):417–423. doi: 10.1007/BF00716383. [DOI] [PubMed] [Google Scholar]
  10. Naline E., Flouvat B., Advenier C., Pays M. Determination of theophylline and its metabolites in plasma and urine by reversed-phase liquid chromatography using an amine modifier. J Chromatogr. 1987 Aug 7;419:177–189. doi: 10.1016/0378-4347(87)80276-1. [DOI] [PubMed] [Google Scholar]
  11. Patel K. R. Terfenadine in exercise induced asthma. Br Med J (Clin Res Ed) 1984 May 19;288(6429):1496–1497. doi: 10.1136/bmj.288.6429.1496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Puurunen J., Sotaniemi E., Pelkonen O. Effect of cimetidine on microsomal drug metabolism in man. Eur J Clin Pharmacol. 1980 Aug;18(2):185–187. doi: 10.1007/BF00561588. [DOI] [PubMed] [Google Scholar]
  13. Rafferty P., Holgate S. T. Terfenadine (Seldane) is a potent and selective histamine H1 receptor antagonist in asthmatic airways. Am Rev Respir Dis. 1987 Jan;135(1):181–184. doi: 10.1164/arrd.1987.135.1.181. [DOI] [PubMed] [Google Scholar]
  14. Taytard A., Beaumont D., Pujet J. C., Sapene M., Lewis P. J. Treatment of bronchial asthma with terfenadine; a randomized controlled trial. Br J Clin Pharmacol. 1987 Dec;24(6):743–746. doi: 10.1111/j.1365-2125.1987.tb03240.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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