Abstract
The use of captopril in heart failure and hypertension is becoming increasingly accepted. Captopril has a sulphydryl group in its molecular structure. We wondered if this might confer free radical scavenging activity on the drug and have investigated this in an in vitro system. Results show that captopril is a free radical scavenger and we suggest that this action might be relevant in its use in heart failure and other vascular diseases.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Breckenridge A. Angiotensin converting enzyme inhibitors. Br Med J (Clin Res Ed) 1988 Feb 27;296(6622):618–620. doi: 10.1136/bmj.296.6622.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chopra M., Belch J. J., Smith W. E. A comparison of the free radical scavenging activity of leukotrienes and prostaglandins. Free Radic Res Commun. 1988;5(2):95–99. doi: 10.3109/10715768809066916. [DOI] [PubMed] [Google Scholar]
- Gervasi P. G., Agrillo M. R., Citti L., Danesi R., Del Tacca M. Superoxide anion production by adriamycinol from cardiac sarcosomes and by mitochondrial NADH dehydrogenase. Anticancer Res. 1986 Sep-Oct;6(5):1231–1235. [PubMed] [Google Scholar]
- Gutteridge J. M. Superoxide dismutase (erythrocuprein) and free radicals in clinical chemistry. Ann Clin Biochem. 1976 May;13(3):393–398. doi: 10.1177/000456327601300125. [DOI] [PubMed] [Google Scholar]
- Heel R. C., Brogden R. N., Speight T. M., Avery G. S. Captopril: a preliminary review of its pharmacological properties and therapeutic efficacy. Drugs. 1980 Dec;20(6):409–452. doi: 10.2165/00003495-198020060-00001. [DOI] [PubMed] [Google Scholar]
- Hommel E., Parving H. H., Mathiesen E., Edsberg B., Damkjaer Nielsen M., Giese J. Effect of captopril on kidney function in insulin-dependent diabetic patients with nephropathy. Br Med J (Clin Res Ed) 1986 Aug 23;293(6545):467–470. doi: 10.1136/bmj.293.6545.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jennings P. E., Jones A. F., Florkowski C. M., Lunec J., Barnett A. H. Increased diene conjugates in diabetic subjects with microangiopathy. Diabet Med. 1987 Sep-Oct;4(5):452–456. doi: 10.1111/j.1464-5491.1987.tb00908.x. [DOI] [PubMed] [Google Scholar]
- Laghi Pasini F., Pasqui A. L., Ceccatelli L., Capecchi P. L., Orrico A., Di Perri T. Heparin inhibition of polymorphonuclear leukocyte activation in vitro. A possible pharmacological approach to granulocyte-mediated vascular damage. Thromb Res. 1984 Sep 1;35(5):527–537. doi: 10.1016/0049-3848(84)90284-6. [DOI] [PubMed] [Google Scholar]
- McCord J. M. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985 Jan 17;312(3):159–163. doi: 10.1056/NEJM198501173120305. [DOI] [PubMed] [Google Scholar]
- McNeil C. J., Banford J. C., Brown D. H., Smith W. E. A relationship between thiols and the superoxide ion. FEBS Lett. 1981 Oct 12;133(1):175–177. doi: 10.1016/0014-5793(81)80498-x. [DOI] [PubMed] [Google Scholar]
- Ortolani O., Biasiucci M., Trebbi A., Cianciulli M., Cuocolo R. Antioxidant drugs and shock therapy. Prog Clin Biol Res. 1987;236A:271–280. [PubMed] [Google Scholar]