Abstract
Changes in peripheral blood flow in response to increasing doses of xamoterol with or without a β2-adrenoceptor blocking agent were assessed in eight healthy volunteers. Xamoterol produced increases in femoral artery diameter, blood volume flow and velocity flow. In the brachial and posterior tibial arteries, systolic blood pressure rose, and in the brachial artery, diastolic blood pressure fell. None of these effects was affected by β2-adrenoceptor blockade. The actions of xamoterol on the circulation are consistent with direct stimulation of myocardial β1-adrenoceptors.
Keywords: xamoterol, peripheral blood flow
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fitzgerald D. E., O'Shaughnessy A. M., Keaveny V. T. Pulsed Doppler: determination of blood velocity and volume flow in normal and diseased common carotid arteries in man. Cardiovasc Res. 1982 Apr;16(4):220–224. doi: 10.1093/cvr/16.4.220. [DOI] [PubMed] [Google Scholar]
- Levenson J. A., Peronneau P. A., Simon A., Safar M. E. Pulsed Doppler: determination of diameter, blood flow velocity, and volumic flow of brachial artery in man. Cardiovasc Res. 1981 Mar;15(3):164–170. doi: 10.1093/cvr/15.3.164. [DOI] [PubMed] [Google Scholar]