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. 1989 Aug;28(2):179–184. doi: 10.1111/j.1365-2125.1989.tb05413.x

Divided-dose kinetics of mefloquine in man.

G Franssen 1, B Rouveix 1, J Lebras 1, J Bauchet 1, F Verdier 1, C Michon 1, F Bricaire 1
PMCID: PMC1379902  PMID: 2789071

Abstract

The kinetics of mefloquine was investigated following oral divided-doses in 10 healthy Caucasian volunteers. They received 500 or 750 mg followed by 500 mg 8 h later. Unchanged mefloquine (M) and its carboxylic acid metabolite (MM) were measured in whole blood and plasma for 50 days by h.p.l.c. Maximum blood and plasma M concentrations of 1872 +/- 362 ng ml-1 (mean +/- s.d.) and 1900 +/- 434 ng ml-1, respectively, were found within 6-10 h after the second dose. The terminal plasma elimination half-life was 20.1 +/- 3.7 days (mean +/- s.d.) and the oral clearance was 22.3 +/- 6.7 ml h-1 kg-1 (mean +/- s.d.). Plasma concentrations of MM exceeded those of M by 2-3 fold within 2 days. The whole blood concentration of MM was lower than that in plasma but also exceeded the whole blood concentration of M.

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Selected References

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