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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1989 Sep;28(3):366–368. doi: 10.1111/j.1365-2125.1989.tb05440.x

Yohimbine increases human salivary secretion.

E Chatelut 1, Y Rispail 1, M Berlan 1, J L Montastruc 1
PMCID: PMC1379958  PMID: 2789932

Abstract

The effect of oral yohimbine (14 mg) on salivary secretion was evaluated in healthy volunteers. Yohimbine significantly increased salivary secretion when compared with placebo. This effect was significant from 60 min until 180 min after administration under our experimental conditions. Yohimbine (or alpha 2-adrenoceptor blocking agents) could have a potential interest in the treatment of dry mouths.

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Selected References

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  1. Galitzky J., Taouis M., Berlan M., Rivière D., Garrigues M., Lafontan M. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest. 1988 Dec;18(6):587–594. doi: 10.1111/j.1365-2362.1988.tb01272.x. [DOI] [PubMed] [Google Scholar]
  2. Green G. J., Wilson H., Yates M. S. The mechanism of the clonidine-induced reduction in peripheral parasympathetic submaxillary salivation. Eur J Pharmacol. 1979 Jul 1;56(4):331–336. doi: 10.1016/0014-2999(79)90263-2. [DOI] [PubMed] [Google Scholar]
  3. Ho A. K., Hoffman D. B., Gershon S., Loh H. H. Distribution and metabolism of tritiated yohimbine in mice. Arch Int Pharmacodyn Ther. 1971 Dec;194(2):304–315. [PubMed] [Google Scholar]
  4. Hubbard J. W., Pfister S. L., Biediger A. M., Herzig T. C., Keeton T. K. The pharmacokinetic properties of yohimbine in the conscious rat. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):583–587. doi: 10.1007/BF00182736. [DOI] [PubMed] [Google Scholar]
  5. Owen J. A., Nakatsu S. L., Fenemore J., Condra M., Surridge D. H., Morales A. The pharmacokinetics of yohimbine in man. Eur J Clin Pharmacol. 1987;32(6):577–582. doi: 10.1007/BF02455991. [DOI] [PubMed] [Google Scholar]
  6. Taouis M., Berlan M., Montastruc P., Lafontan M. Mechanism of the lipid-mobilizing effect of alpha-2 adrenergic antagonists in the dog. J Pharmacol Exp Ther. 1988 Dec;247(3):1172–1180. [PubMed] [Google Scholar]

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