Abstract
Twenty hypertensive patients received single oral doses of pseudoephedrine 60 mg or placebo in a double-blind, randomised, crossover trial. Systolic, diastolic, mean arterial blood pressure, and heart rate were measured at 5 min intervals for 30 min prior to and 210 min after the administration of pseudoephedrine or placebo. Statistically significant differences between the two treatments were observed with changes in systolic blood pressure (P less than 0.03) and heart rate (P less than 0.01) but not in diastolic (P greater than 0.03) and mean arterial blood pressure (P greater than 0.1). Minor differences in the number of reported side effects between the two treatments were not statistically significant.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boyd J. R. Nonprescription drug screening. Pseudoephedrine. Am Pharm. 1986 Nov;NS26(11):22–24. doi: 10.1016/s0160-3450(16)33105-1. [DOI] [PubMed] [Google Scholar]
- Bristow J. D., Honour A. J., Pickering G. W., Sleight P., Smyth H. S. Diminished baroreflex sensitivity in high blood pressure. Circulation. 1969 Jan;39(1):48–54. doi: 10.1161/01.cir.39.1.48. [DOI] [PubMed] [Google Scholar]
- Chua S. S., Benrimoj S. I. Non-prescription sympathomimetic agents and hypertension. Med Toxicol Adverse Drug Exp. 1988 Sep-Oct;3(5):387–417. doi: 10.1007/BF03259892. [DOI] [PubMed] [Google Scholar]
- Empey D. W., Young G. A., Letley E., John G. C., Smith P., McDonnell K. A., Bagg L. R., Hughes D. T. Dose-response study of the nasal decongestant and cardiovascular effects of pseudoephedrine. Br J Clin Pharmacol. 1980 Apr;9(4):351–358. doi: 10.1111/j.1365-2125.1980.tb01061.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greening G. K. The effect of an antihistamine-pseudoephedrine drug on the blood pressure of moderate hypertensives. Curr Ther Res Clin Exp. 1969 May;11(5):252–255. [PubMed] [Google Scholar]
- Gribbin B., Pickering T. G., Sleight P., Peto R. Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res. 1971 Oct;29(4):424–431. doi: 10.1161/01.res.29.4.424. [DOI] [PubMed] [Google Scholar]