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. 1990 May;29(5):525–531. doi: 10.1111/j.1365-2125.1990.tb03675.x

The abnormal in vitro response to aspirin of platelets from aspirin-sensitive asthmatics is inhibited after inhalation of nedocromil sodium but not of sodium cromoglycate.

C H Marquette 1, M Joseph 1, A B Tonnel 1, H Vorng 1, P Lassalle 1, A Tsicopoulos 1, A Capron 1
PMCID: PMC1380151  PMID: 2161678

Abstract

1. Blood platelets from patients with aspirin-sensitive asthma (ASA) generated cytotoxic mediators in the presence of aspirin. This abnormal in vitro response to aspirin was abolished within 1 h after nedocromil sodium inhalation but not after sodium cromoglycate inhalation. 2. Platelets recovered this reactivity to aspirin by 12 hours after nedocromil sodium treatment of ASA-patients. 3. The in vitro reactivity to aspirin of ASA platelets isolated before inhalation was inhibited in the presence of serum isolated 15 and 60 min after nedocromil sodium inhalation.

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Selected References

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