Abstract
Serial audiometry was performed in ten patients receiving quinine treatment for acute falciparum malaria. Quinine reduced high tone auditory acuity in all patients, resulting in flattening of the audiograms. The effect was rapid in onset, usually unnoticed (although tinnitus was reported in seven patients), and resolved completely after treatment was completed.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cibis G. W., Burian H. M., Blodi F. C. Electroretinogram changes in acute quinine poisoning. Arch Ophthalmol. 1973 Oct;90(4):307–309. doi: 10.1001/archopht.1973.01000050309014. [DOI] [PubMed] [Google Scholar]
- Koegel L., Jr Ototoxicity: a contemporary review of aminoglycosides, loop diuretics, acetylsalicylic acid, quinine, erythromycin, and cisplatinum. Am J Otol. 1985 Mar;6(2):190–199. [PubMed] [Google Scholar]
- RUEDI L., FURRER W., LUTHY F., NAGER G., TSCHIRREN B. Further observations concerning the toxic effects of streptomycin and quinine on the auditory organ of guinea pigs. Laryngoscope. 1952 Apr;62(4):333–351. doi: 10.1288/00005537-195204000-00001. [DOI] [PubMed] [Google Scholar]
- Silamut K., White N. J., Looareesuwan S., Warrell D. A. Binding of quinine to plasma proteins in falciparum malaria. Am J Trop Med Hyg. 1985 Jul;34(4):681–686. doi: 10.4269/ajtmh.1985.34.681. [DOI] [PubMed] [Google Scholar]
- White N. J. Drug treatment and prevention of malaria. Eur J Clin Pharmacol. 1988;34(1):1–14. doi: 10.1007/BF01061409. [DOI] [PubMed] [Google Scholar]
- White N. J., Looareesuwan S., Warrell D. A., Warrell M. J., Bunnag D., Harinasuta T. Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med. 1982 Oct;73(4):564–572. doi: 10.1016/0002-9343(82)90337-0. [DOI] [PubMed] [Google Scholar]
