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. 1996 Sep;86(9):1241–1246. doi: 10.2105/ajph.86.9.1241

Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) concentrations in the breast milk of women in Quebec.

E Dewailly 1, P Ayotte 1, C Laliberté 1, J P Weber 1, S Gingras 1, A J Nantel 1
PMCID: PMC1380586  PMID: 8806375

Abstract

OBJECTIVES: This study documented the concentration of polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethylene (DDE) in the breast milk of women from Quebec, Canada, and assessed the impact of various sociodemographic and lifestyle factors on these levels. METHODS: From 1988 to 1990, milk samples were obtained from 536 Quebec women and analyzed for seven PCB congeners and p,p'-DDE. Information was obtained on subjects' physical, sociodemographic, and lifestyle characteristics. RESULTS: Mean concentrations were 0.52 mg/kg lipids (95% confidence interval [CI] = 0.50, 0.54) and 0.34 mg/kg lipids (95% CI = 0.32, 0.35) for PCBs (Aroclor 1260) and DDE, respectively. Age and history of breast-feeding showed statistically significant correlations with PCB and DDE concentrations. CONCLUSIONS: Concentrations of PCBs and DDE measured in this study are at the lower end of the concentration range recently reported for women living in industrialized countries. The modulating factors identified here should be considered when conducting studies on organochlorine exposure and disease.

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Selected References

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  1. Bates M. N., Hannah D. J., Buckland S. J., Taucher J. A., van Maanen T. Chlorinated organic contaminants in breast milk of New Zealand women. Environ Health Perspect. 1994 Jan;102 (Suppl 1):211–217. doi: 10.1289/ehp.94102s1211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Colborn T., vom Saal F. S., Soto A. M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993 Oct;101(5):378–384. doi: 10.1289/ehp.93101378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Currie R. A., Kadis V. W., Breitkreitz W. E., Cunningham G. B., Bruns G. W. Pesticide residues in human milk, Alberta, Canada--1966-70, 1977-78. Pestic Monit J. 1979 Sep;13(2):52–55. [PubMed] [Google Scholar]
  4. Davis D. L., Bradlow H. L., Wolff M., Woodruff T., Hoel D. G., Anton-Culver H. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect. 1993 Oct;101(5):372–377. doi: 10.1289/ehp.93101372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dewailly E., Ayotte P., Bruneau S., Laliberté C., Muir D. C., Norstrom R. J. Inuit exposure to organochlorines through the aquatic food chain in arctic québec. Environ Health Perspect. 1993 Dec;101(7):618–620. doi: 10.1289/ehp.93101618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dewailly E., Dodin S., Verreault R., Ayotte P., Sauvé L., Morin J., Brisson J. High organochlorine body burden in women with estrogen receptor-positive breast cancer. J Natl Cancer Inst. 1994 Feb 2;86(3):232–234. doi: 10.1093/jnci/86.3.232. [DOI] [PubMed] [Google Scholar]
  7. Dewailly E., Weber J. P., Gingras S., Laliberté C. Coplanar PCBs in human milk in the province of Québec, Canada: are they more toxic than dioxin for breast fed infants? Bull Environ Contam Toxicol. 1991 Oct;47(4):491–498. doi: 10.1007/BF01700935. [DOI] [PubMed] [Google Scholar]
  8. Dillon J. C., Martin G. B., O'Brien H. T. Pesticide residues in human milk. Food Cosmet Toxicol. 1981 Aug;19(4):437–442. doi: 10.1016/0015-6264(81)90447-8. [DOI] [PubMed] [Google Scholar]
  9. Drijver M., Duijkers T. J., Kromhout D., Visser T. J., Mulder P., Louw R. Determinants of polychlorinated biphenyls (PCBs) in human milk. Acta Paediatr Scand. 1988 Jan;77(1):30–36. doi: 10.1111/j.1651-2227.1988.tb10593.x. [DOI] [PubMed] [Google Scholar]
  10. Ecobichon D. J., Saschenbrecker P. W. Pharmacodynamic study of DDT in cockerels. Can J Physiol Pharmacol. 1968 Sep;46(5):785–794. doi: 10.1139/y68-121. [DOI] [PubMed] [Google Scholar]
  11. Falck F., Jr, Ricci A., Jr, Wolff M. S., Godbold J., Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health. 1992 Mar-Apr;47(2):143–146. [PubMed] [Google Scholar]
  12. Fürst P., Fürst C., Wilmers K. Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs. Environ Health Perspect. 1994 Jan;102 (Suppl 1):187–193. doi: 10.1289/ehp.102-1566908. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Geyer H., Scheunert I., Korte F. Bioconcentration potential of organic environmental chemicals in humans. Regul Toxicol Pharmacol. 1986 Dec;6(4):313–347. doi: 10.1016/0273-2300(86)90002-4. [DOI] [PubMed] [Google Scholar]
  14. Hernández L. M., Fernández M. A., Hoyas E., González M. J., García J. F. Organochlorine insecticide and polychlorinated biphenyl residues in human breast milk in Madrid (Spain). Bull Environ Contam Toxicol. 1993 Feb;50(2):308–315. doi: 10.1007/BF00191738. [DOI] [PubMed] [Google Scholar]
  15. Jain M. G., Harrison L., Howe G. R., Miller A. B. Evaluation of a self-administered dietary questionnaire for use in a cohort study. Am J Clin Nutr. 1982 Nov;36(5):931–935. doi: 10.1093/ajcn/36.5.931. [DOI] [PubMed] [Google Scholar]
  16. Johansen H. R., Becher G., Polder A., Skaare J. U. Congener-specific determination of polychlorinated biphenyls and organochlorine pesticides in human milk from Norwegian mothers living in Oslo. J Toxicol Environ Health. 1994 Jun;42(2):157–171. doi: 10.1080/15287399409531870. [DOI] [PubMed] [Google Scholar]
  17. Kreiss K. Studies on populations exposed to polychlorinated biphenyls. Environ Health Perspect. 1985 May;60:193–199. doi: 10.1289/ehp.8560193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kreiss K., Zack M. M., Kimbrough R. D., Needham L. L., Smrek A. L., Jones B. T. Cross-sectional study of a community with exceptional exposure to DDT. JAMA. 1981 May 15;245(19):1926–1930. [PubMed] [Google Scholar]
  19. Mes J., Davies D. J., Turton D., Sun W. F. Levels and trends of chlorinated hydrocarbon contaminants in the breast milk of Canadian women. Food Addit Contam. 1986 Oct-Dec;3(4):313–322. doi: 10.1080/02652038609373598. [DOI] [PubMed] [Google Scholar]
  20. Morgan D. P., Roan C. C. Absorption, storage, and metabolic conversion of ingested DDT and DDT metabolites in man. Arch Environ Health. 1971 Mar;22(3):301–308. doi: 10.1080/00039896.1971.10665848. [DOI] [PubMed] [Google Scholar]
  21. Newcomb P. A., Storer B. E., Longnecker M. P., Mittendorf R., Greenberg E. R., Clapp R. W., Burke K. P., Willett W. C., MacMahon B. Lactation and a reduced risk of premenopausal breast cancer. N Engl J Med. 1994 Jan 13;330(2):81–87. doi: 10.1056/NEJM199401133300201. [DOI] [PubMed] [Google Scholar]
  22. Pike M. C., Spicer D. V., Dahmoush L., Press M. F. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev. 1993;15(1):17–35. doi: 10.1093/oxfordjournals.epirev.a036102. [DOI] [PubMed] [Google Scholar]
  23. Polishuk Z. W., Ron M., Wassermann M., Cucos S., Wassermann D., Lemesch C. Organochlorine compounds in human blood plasma and milk. Pestic Monit J. 1977 Mar;10(4):121–129. [PubMed] [Google Scholar]
  24. Ritcey W. R., Savary G., McCully K. A. Organochlorine insecticide residues in human milk, evaporated milk and some milk substitutes in Canada. Can J Public Health. 1972 Mar-Apr;63(2):125–132. [PubMed] [Google Scholar]
  25. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tinglestad J., Tully M. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr. 1986 Aug;109(2):335–341. doi: 10.1016/s0022-3476(86)80397-3. [DOI] [PubMed] [Google Scholar]
  26. Safe S. H. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol. 1994;24(2):87–149. doi: 10.3109/10408449409049308. [DOI] [PubMed] [Google Scholar]
  27. Schwartz P. M., Jacobson S. W., Fein G., Jacobson J. L., Price H. A. Lake Michigan fish consumption as a source of polychlorinated biphenyls in human cord serum, maternal serum, and milk. Am J Public Health. 1983 Mar;73(3):293–296. doi: 10.2105/ajph.73.3.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Stacey C. I., Thomas B. W. Organochlorine pesticide residies in human milk, Western Australia--1970-71. Pestic Monit J. 1975 Sep;9(2):64–66. [PubMed] [Google Scholar]
  29. Takahashi W., Saidin D., Takei G., Wong L. Organochloride pesticide residues in human milk in Hawaii, 1979-80. Bull Environ Contam Toxicol. 1981 Oct;27(4):506–511. doi: 10.1007/BF01611056. [DOI] [PubMed] [Google Scholar]
  30. Vaz R., Slorach S. A., Hofvander Y. Organochlorine contaminants in Swedish human milk: studies conducted at the National Food Administration 1981-1990. Food Addit Contam. 1993 Jul-Aug;10(4):407–418. doi: 10.1080/02652039309374164. [DOI] [PubMed] [Google Scholar]
  31. Watanabe I., Yakushiji T., Kuwabara K., Yoshida S., Maeda K., Kashimoto T., Koyama K., Kunita N. Surveillance of the daily PCB intake from diet of Japanese women from 1972 through 1976. Arch Environ Contam Toxicol. 1979;8(1):67–75. doi: 10.1007/BF01055141. [DOI] [PubMed] [Google Scholar]
  32. Wickizer T. M., Brilliant L. B. Testing for polychlorinated biphenyls in human milk. Pediatrics. 1981 Sep;68(3):411–415. [PubMed] [Google Scholar]
  33. Wolff M. S., Thornton J., Fischbein A., Lilis R., Selikoff I. J. Disposition of polychlorinated biphenyl congeners in occupationally exposed persons. Toxicol Appl Pharmacol. 1982 Feb;62(2):294–306. doi: 10.1016/0041-008x(82)90128-4. [DOI] [PubMed] [Google Scholar]
  34. Wolff M. S., Toniolo P. G., Lee E. W., Rivera M., Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst. 1993 Apr 21;85(8):648–652. doi: 10.1093/jnci/85.8.648. [DOI] [PubMed] [Google Scholar]

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