Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1992 Mar;33(3):337–341. doi: 10.1111/j.1365-2125.1992.tb04048.x

Inhaled histamine increases the rate of absorption of sodium cromoglycate from the lung.

R Richards 1, C Fowler 1, S Simpson 1, A G Renwick 1, S T Holgate 1
PMCID: PMC1381288  PMID: 1576060

Abstract

Since many factors may alter lung epithelial permeability (LEP) to water soluble molecules, the effect of histamine on the absorption and clearance of inhaled sodium cromoglycate was examined in seven mildly asthmatic patients with hyperresponsive airways and eight normal subjects. The subjects underwent histamine challenge to determine the provocative concentration of histamine required to reduce the forced expiratory volume in one second (FEV1) by 20% (PC20) from baseline. On two further visits they inhaled either saline placebo or histamine and 5 min later inhaled an aerosol containing sodium cromoglycate. Measurements of FEV1 were made and blood samples taken for analysis of plasma sodium cromoglycate concentration at intervals for 3 h. In the asthmatic group histamine inhalation led to a 24 +/- 4% reduction in FEV1 but had no effect on the normal subjects. When compared with inhaled saline, histamine increased the initial pulmonary absorption of SCG without influencing the total amount of drug absorbed in both asthmatics and normals. These observations suggest that the pharmacokinetics of inhaled sodium cromoglycate may be altered significantly by inflammatory mediators present at the site of drug absorption from the airways.

Full text

PDF
337

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Braude S., Royston D., Coe C., Barnes P. J. Histamine increases lung permeability by an H2-receptor mechanism. Lancet. 1984 Aug 18;2(8399):372–374. doi: 10.1016/s0140-6736(84)90542-7. [DOI] [PubMed] [Google Scholar]
  2. Brown K., Gardner J. J., Lockley W. J., Preston J. R., Wilkinson D. J. Radioimmunoassay of sodium cromoglycate in human plasma. Ann Clin Biochem. 1983 Jan;20(Pt 1):31–36. doi: 10.1177/000456328302000105. [DOI] [PubMed] [Google Scholar]
  3. Chai H., Farr R. S., Froehlich L. A., Mathison D. A., McLean J. A., Rosenthal R. R., Sheffer A. L., Spector S. L., Townley R. G. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975 Oct;56(4):323–327. doi: 10.1016/0091-6749(75)90107-4. [DOI] [PubMed] [Google Scholar]
  4. Chan T. B., Eiser N., Shelton D., Rees P. J. Histamine receptors and pulmonary epithelial permeability. Br J Dis Chest. 1987 Jul;81(3):260–267. doi: 10.1016/0007-0971(87)90159-8. [DOI] [PubMed] [Google Scholar]
  5. Djukanović R., Roche W. R., Wilson J. W., Beasley C. R., Twentyman O. P., Howarth R. H., Holgate S. T. Mucosal inflammation in asthma. Am Rev Respir Dis. 1990 Aug;142(2):434–457. doi: 10.1164/ajrccm/142.2.434. [DOI] [PubMed] [Google Scholar]
  6. Dunnill M. S., Massarella G. R., Anderson J. A. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax. 1969 Mar;24(2):176–179. doi: 10.1136/thx.24.2.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Elwood R. K., Kennedy S., Belzberg A., Hogg J. C., Paré P. D. Respiratory mucosal permeability in asthma. Am Rev Respir Dis. 1983 Sep;128(3):523–527. doi: 10.1164/arrd.1983.128.3.523. [DOI] [PubMed] [Google Scholar]
  8. Fuller R. W., Collier J. G. The pharmacokinetic assessment of sodium cromoglycate. J Pharm Pharmacol. 1983 May;35(5):289–292. doi: 10.1111/j.2042-7158.1983.tb02936.x. [DOI] [PubMed] [Google Scholar]
  9. Gellert A. R., Lewis C. A., Langford J. A., Tolfree S. E., Rudd R. M. Regional distribution of pulmonary epithelial permeability in normal subjects and patients with asbestosis. Thorax. 1985 Oct;40(10):734–740. doi: 10.1136/thx.40.10.734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Howarth P. H., Durham S. R., Kay A. B., Holgate S. T. The relationship between mast cell-mediator release and bronchial reactivity in allergic asthma. J Allergy Clin Immunol. 1987 Nov;80(5):703–711. doi: 10.1016/0091-6749(87)90291-0. [DOI] [PubMed] [Google Scholar]
  11. Jacobs M. P., Baughman R. P., Hughes J., Fernandez-Ulloa M. Radioaerosol lung clearance in patients with active pulmonary sarcoidosis. Am Rev Respir Dis. 1985 May;131(5):687–689. doi: 10.1164/arrd.1985.131.5.687. [DOI] [PubMed] [Google Scholar]
  12. Laitinen L. A., Heino M., Laitinen A., Kava T., Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis. 1985 Apr;131(4):599–606. doi: 10.1164/arrd.1985.131.4.599. [DOI] [PubMed] [Google Scholar]
  13. Laitinen L. A., Laitinen M. A., Widdicombe J. G. Dose-related effects of pharmacological mediators on tracheal vascular resistance in dogs. Br J Pharmacol. 1987 Dec;92(4):703–709. doi: 10.1111/j.1476-5381.1987.tb11374.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Laitinen L. A., Robinson N. P., Laitinen A., Widdicombe J. G. Relationship between tracheal mucosal thickness and vascular resistance in dogs. J Appl Physiol (1985) 1986 Dec;61(6):2186–2193. doi: 10.1152/jappl.1986.61.6.2186. [DOI] [PubMed] [Google Scholar]
  15. Long W. M., Sprung C. L., el Fawal H., Yerger L. D., Eyre P., Abraham W. M., Wanner A. Effects of histamine on bronchial artery blood flow and bronchomotor tone. J Appl Physiol (1985) 1985 Jul;59(1):254–261. doi: 10.1152/jappl.1985.59.1.254. [DOI] [PubMed] [Google Scholar]
  16. Neale M. G., Brown K., Hodder R. W., Auty R. M. The pharmacokinetics of sodium cromoglycate in man after intravenous and inhalation administration. Br J Clin Pharmacol. 1986 Oct;22(4):373–382. doi: 10.1111/j.1365-2125.1986.tb02905.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. O'Brodovich H., Coates G. Pulmonary clearance of 99mTc-DTPA: a noninvasive assessment of epithelial integrity. Lung. 1987;165(1):1–16. doi: 10.1007/BF02714416. [DOI] [PubMed] [Google Scholar]
  18. Olanoff L. S., Titus C. R., Shea M. S., Gibson R. E., Brooks C. D. Effect of intranasal histamine on nasal mucosal blood flow and the antidiuretic activity of desmopressin. J Clin Invest. 1987 Sep;80(3):890–895. doi: 10.1172/JCI113148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rafferty P., Beasley R., Holgate S. T. The contribution of histamine to immediate bronchoconstriction provoked by inhaled allergen and adenosine 5' monophosphate in atopic asthma. Am Rev Respir Dis. 1987 Aug;136(2):369–373. doi: 10.1164/ajrccm/136.2.369. [DOI] [PubMed] [Google Scholar]
  20. Rafferty P., Holgate S. T. Histamine and its antagonists in asthma. J Allergy Clin Immunol. 1989 Aug;84(2):144–151. doi: 10.1016/0091-6749(89)90317-5. [DOI] [PubMed] [Google Scholar]
  21. Rees P. J., Shelton D., Chan T. B., Eiser N., Clark T. J., Maisey M. N. Effects of histamine on lung permeability in normal and asthmatic subjects. Thorax. 1985 Aug;40(8):603–606. doi: 10.1136/thx.40.8.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Richards R., Dickson C. R., Renwick A. G., Lewis R. A., Holgate S. T. Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique. J Pharmacol Exp Ther. 1987 Jun;241(3):1028–1032. [PubMed] [Google Scholar]
  23. Richards R., Haas A., Simpson S., Britten A., Renwick A., Holgate S. Effect of methacholine induced bronchoconstriction on the pulmonary distribution and plasma pharmacokinetics of inhaled sodium cromoglycate in subjects with normal and hyperreactive airways. Thorax. 1988 Aug;43(8):611–616. doi: 10.1136/thx.43.8.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Rizk N. W., Luce J. M., Hoeffel J. M., Price D. C., Murray J. F. Site of deposition and factors affecting clearance of aerosolized solute from canine lungs. J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):723–729. doi: 10.1152/jappl.1984.56.3.723. [DOI] [PubMed] [Google Scholar]
  25. Schanker L. S. Drug absorption from the lung. Biochem Pharmacol. 1978 Feb 15;27(4):381–385. doi: 10.1016/0006-2952(78)90365-9. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES