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. 1992 Apr;33(4):395–399. doi: 10.1111/j.1365-2125.1992.tb04057.x

An evaluation of buffered aspirin and aspirin tablets in postoperative pain after third molar surgery.

R A Seymour 1, M Weldon 1, P Kelly 1, E Nicholson 1, J E Hawkesford 1
PMCID: PMC1381328  PMID: 1576068

Abstract

1. Single doses (500 and 1000 mg) of both buffered aspirin and aspirin tablets were compared with placebo in a randomised double-blind trial of parallel design in patients with postoperative pain after third molar surgery. 2. Only buffered aspirin 500 mg provided significant pain relief (P = 0.016) during the 5 h investigation period. 3. A significant correlation (P = 0.004) was observed between overall pain scores after the various aspirin treatments and aspirin esterase activity. 4. Buffered aspirin preparations afforded a slight advantage over aspirin tablets in the control of postoperative pain after third molar surgery. However, the duration of analgesia was short (approximately 2 h). 5. Aspirin esterase activity appears to be an important determinant of the drug's efficacy in postoperative dental pain.

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Selected References

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