Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1992 Apr;33(4):458–460. doi: 10.1111/j.1365-2125.1992.tb04069.x

Effect of high ambient temperature on the kinetics of the pupillary light reflex in healthy volunteers.

N K Leung 1, C M Bradshaw 1, E Szabadi 1
PMCID: PMC1381340  PMID: 1576072

Abstract

Miotic responses to brief light stimuli were studied in healthy volunteers under two ambient temperature conditions, 22 degrees C and 40 degrees C. The latency and amplitude of the light reflex did not differ between the two conditions, but the recovery time of the reflex was significantly shorter under the 40 degrees C condition than under the 22 degrees C condition. The results are consistent with the hypothesis that exposure to high ambient temperature results in an increased sympathetic drive to the iris dilator muscle but does not influence the parasympathetic light reflex.

Full text

PDF
458

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bakes A., Bradshaw C. M., Szabadi E. Attenuation of the pupillary light reflex in anxious patients. Br J Clin Pharmacol. 1990 Sep;30(3):377–381. doi: 10.1111/j.1365-2125.1990.tb03787.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Banjar W., Longmore J., Bradshaw C. M., Szabadi E. The effect of diazepam on the responsiveness of human eccrine sweat glands to carbachol: influence of ambient temperature. Eur J Clin Pharmacol. 1987;31(6):661–665. doi: 10.1007/BF00541292. [DOI] [PubMed] [Google Scholar]
  3. Bini G., Hagbarth K. E., Hynninen P., Wallin B. G. Regional similarities and differences in thermoregulatory vaso- and sudomotor tone. J Physiol. 1980 Sep;306:553–565. doi: 10.1113/jphysiol.1980.sp013414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kobinger Central alpha-adrenergic systems as targets for hypotensive drugs. Rev Physiol Biochem Pharmacol. 1978;81:39–100. doi: 10.1007/BFb0034091. [DOI] [PubMed] [Google Scholar]
  5. Morley M. J., Bradshaw C. M., Szabadi E. Effects of clonidine and yohimbine on the pupillary light reflex and carbachol-evoked sweating in healthy volunteers. Br J Clin Pharmacol. 1991 Jan;31(1):99–101. doi: 10.1111/j.1365-2125.1991.tb03864.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES