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. 1992 Jun;33(6):611–615. doi: 10.1111/j.1365-2125.1992.tb04089.x

Autoinduction and steady-state pharmacokinetics of carbamazepine and its major metabolites.

T B Kudriakova 1, L A Sirota 1, G I Rozova 1, V A Gorkov 1
PMCID: PMC1381352  PMID: 1389933

Abstract

1. The effect of carbamazepine (CBZ) dose change on mean plasma concentrations of CBZ, its two metabolites and apparent steady-state clearance was studied in 77 affectively ill patients receiving CBZ at doses of 100-1200 mg day-1. 2. Autoinduction of CBZ metabolism appeared to be complete within 1 week of starting CBZ therapy or dose change, and its degree was linearly related to CBZ daily dose. 3. Curvilinear plots were obtained for steady-state concentrations of CBZ and its -10,11-epoxide metabolite, and for the ratio of CBZ-10,11-epoxide to CBZ level, versus daily dose of CBZ. 4. On the contrary, steady-state concentration of CBZ-10,11-diol increased proportionately with the dose. This indicates that there is no dose dependency in absorption of CBZ, and that dose-dependent autoinduction of CBZ metabolism is the main cause of the curvilinear relationship between dose and steady-state concentration of CBZ and its intermediary metabolite, CBZ-10,11-epoxide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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