Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1992 Jun;33(6):629–633. doi: 10.1111/j.1365-2125.1992.tb04092.x

The pharmacokinetics of mecillinam and pivmecillinam in pregnant and non-pregnant women.

A Heikkilä 1, K Pyykkö 1, R Erkkola 1, E Iisalo 1
PMCID: PMC1381355  PMID: 1389936

Abstract

1. The pharmacokinetics of parenteral mecillinam (n = 27) and oral pivmecillinam (n = 12) were studied in pregnant (n = 27) and non-pregnant (n = 12) subjects. 2. In early pregnancy (9-14 weeks of gestation) the mean peak plasma drug concentration (Cmax = 19 +/- 9 micrograms ml-1) after an intravenous injection of 200 mg mecillinam was significantly lower (P less than 0.05) and the volume of distribution (V = 49 +/- 20.1) significantly larger (P less than 0.05) than in non-pregnant subjects (Cmax = 35 +/- 18 micrograms ml-1, V = 29 +/- 12.1). In late pregnancy (39-40 weeks of gestation) the plasma mean peak concentration (Cmax = (29 +/- 14 micrograms ml-1) after parenteral administration of 200 mg mecillinam was slightly lower and the volume of distribution (V = 65 +/- 29.1, V = 0.9 +/- 0.4 l kg-1) significantly larger than that in non-pregnant subjects (V = 0.4 +/- 0.3 l kg-1). Also after oral administration of 200 mg pivmecillinam, equimolar to 136.5 mg mecillinam, the mean peak plasma concentration in pregnant subjects (Cmax = 1.8 +/- 1.2 micrograms ml-1) was slightly lower than that in non-pregnant subjects (Cmax = 1.7 +/- 1.2 micrograms ml-1). 3. The mean half-life of elimination after parenteral administration of mecillinam was significantly longer during both early (t1/2,Z = 133 +/- 38 min, P less than 0.05) and late pregnancy (t1/2,Z = 107 +/- 41 min, P less than 0.05) as compared with the non-pregnant state (t1/2,Z = 75 +/- 21 min).(ABSTRACT TRUNCATED AT 250 WORDS)

Full text

PDF
629

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brumfitt W., Franklin I., Hamilton-Miller J., Anderson F. Comparison of pivmecillinam and cephradine in bacteriuria in pregnancy and in acute urinary tract infection. Scand J Infect Dis. 1979;11(4):275–279. doi: 10.3109/inf.1979.11.issue-4.04. [DOI] [PubMed] [Google Scholar]
  2. Cleeland R., Squires E. Enhanced activity of beta-lactam antibiotics with amdinocillin in vitro and and in vivo. Am J Med. 1983 Aug 29;75(2A):21–29. doi: 10.1016/0002-9343(83)90090-6. [DOI] [PubMed] [Google Scholar]
  3. Cox C. E. Parenteral amdinocillin for treatment of complicated urinary tract infections. Am J Med. 1983 Aug 29;75(2A):82–84. doi: 10.1016/0002-9343(83)90099-2. [DOI] [PubMed] [Google Scholar]
  4. Demos C. H., Green E. Review of clinical experience with amdinocillin monotherapy and comparative studies. Am J Med. 1983 Aug 29;75(2A):72–81. doi: 10.1016/0002-9343(83)90098-0. [DOI] [PubMed] [Google Scholar]
  5. Gambertoglio J. G., Barriere S. L., Lin E. T., Conte J. E., Jr Pharmacokinetics of mecillinam in health subjects. Antimicrob Agents Chemother. 1980 Dec;18(6):952–956. doi: 10.1128/aac.18.6.952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Godtfredsen W. O. An introduction to mecillinam. J Antimicrob Chemother. 1977 Jul;3 (Suppl B):1–4. doi: 10.1093/jac/3.suppl_b.1. [DOI] [PubMed] [Google Scholar]
  7. Heikkilä A., Erkkola R. Pharmacokinetics of piperacillin during pregnancy. J Antimicrob Chemother. 1991 Sep;28(3):419–423. doi: 10.1093/jac/28.3.419. [DOI] [PubMed] [Google Scholar]
  8. Kjer J. J., Ottesen B. Pharmacokinetics of pivmecillinam hydrochloride in pregnant and non-pregnant women. Acta Pharmacol Toxicol (Copenh) 1986 Nov;59(5):430–431. doi: 10.1111/j.1600-0773.1986.tb00195.x. [DOI] [PubMed] [Google Scholar]
  9. Lee T. L., Brooks M. A. Determination of amdinocillin in plasma and urine by high-performance liquid chromatography. J Chromatogr. 1982 Jan 8;227(1):137–148. doi: 10.1016/s0378-4347(00)80363-1. [DOI] [PubMed] [Google Scholar]
  10. Meyers B. R., Jacobson J., Masci J., Srulevitch E., Hirschman S. Z. Pharmacokinetics of amdinocillin in healthy adults. Antimicrob Agents Chemother. 1983 Jun;23(6):827–830. doi: 10.1128/aac.23.6.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Neu H. C. Mecillinam--an amidino penicillin which acts synergistically with other beta-lactam compounds. J Antimicrob Chemother. 1977 Jul;3 (Suppl B):43–52. doi: 10.1093/jac/3.suppl_b.43. [DOI] [PubMed] [Google Scholar]
  12. Reeves D. S. Antibacterial activity of mecillinam. J Antimicrob Chemother. 1977 Jul;3 (Suppl B):5–11. doi: 10.1093/jac/3.suppl_b.5. [DOI] [PubMed] [Google Scholar]
  13. Reeves D. S., Wise R., Bywater M. J. A laboratory evaluation of a novel (beta-lactam antibiotic mecillinam. J Antimicrob Chemother. 1975 Sep;1(3):337–344. doi: 10.1093/jac/1.3.337. [DOI] [PubMed] [Google Scholar]
  14. Reynolds F., Knott C. Pharmacokinetics in pregnancy and placental drug transfer. Oxf Rev Reprod Biol. 1989;11:389–449. [PubMed] [Google Scholar]
  15. Sanderson P., Menday P. Pivmecillinam for bacteriuria in pregnancy. J Antimicrob Chemother. 1984 Apr;13(4):383–388. doi: 10.1093/jac/13.4.383. [DOI] [PubMed] [Google Scholar]
  16. Tybring L. Mecillinam (FL 1060), a 6beta-amidinopenicillanic acid derivative: in vitro evaluation. Antimicrob Agents Chemother. 1975 Sep;8(3):266–270. doi: 10.1128/aac.8.3.266. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES