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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1992 Jul;34(1):1–10. doi: 10.1111/j.1365-2125.1992.tb04100.x

Antimalarial pharmacokinetics and treatment regimens.

N J White 1
PMCID: PMC1381368  PMID: 1633062

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Björkman A., Steffen R., Armengaud M., Picot N., Piccoli S. Malaria chemoprophylaxis with mefloquine. Lancet. 1991 Jun 15;337(8755):1479–1480. doi: 10.1016/0140-6736(91)93168-9. [DOI] [PubMed] [Google Scholar]
  2. Boland M. E., Roper S. M., Henry J. A. Complications of quinine poisoning. Lancet. 1985 Feb 16;1(8425):384–385. doi: 10.1016/s0140-6736(85)91398-4. [DOI] [PubMed] [Google Scholar]
  3. Chongsuphajaisiddhi T., Sabcharoen A., Attanath P. In vivo and in vitro sensitivity of Falciparum malaria to quinine in Thai children. Ann Trop Paediatr. 1981 Mar;1(1):21–26. doi: 10.1080/02724936.1981.11748054. [DOI] [PubMed] [Google Scholar]
  4. Davis T. M., White N. J., Looareesuwan S., Silamut K., Warrell D. A. Quinine pharmacokinetics in cerebral malaria: predicted plasma concentrations after rapid intravenous loading using a two-compartment model. Trans R Soc Trop Med Hyg. 1988;82(4):542–547. doi: 10.1016/0035-9203(88)90498-1. [DOI] [PubMed] [Google Scholar]
  5. Desjardins R. E., Pamplin C. L., 3rd, von Bredow J., Barry K. G., Canfield C. J. Kinetics of a new antimalarial, mefloquine. Clin Pharmacol Ther. 1979 Sep;26(3):372–379. doi: 10.1002/cpt1979263372. [DOI] [PubMed] [Google Scholar]
  6. Dyson E. H., Proudfoot A. T., Prescott L. F., Heyworth R. Death and blindness due to overdose of quinine. Br Med J (Clin Res Ed) 1985 Jul 6;291(6487):31–33. doi: 10.1136/bmj.291.6487.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Frisk-Holmberg M., Bergqvist Y., Termond E., Domeij-Nyberg B. The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects. Eur J Clin Pharmacol. 1984;26(4):521–530. doi: 10.1007/BF00542151. [DOI] [PubMed] [Google Scholar]
  8. Gustafsson L. L., Walker O., Alván G., Beermann B., Estevez F., Gleisner L., Lindström B., Sjöqvist F. Disposition of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol. 1983 Apr;15(4):471–479. doi: 10.1111/j.1365-2125.1983.tb01532.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hellgren U., Kihamia C. M., Mahikwano L. F., Björkman A., Eriksson O., Rombo L. Response of Plasmodium falciparum to chloroquine treatment: relation to whole blood concentrations of chloroquine and desethylchloroquine. Bull World Health Organ. 1989;67(2):197–202. [PMC free article] [PubMed] [Google Scholar]
  10. Karbwang J., White N. J. Clinical pharmacokinetics of mefloquine. Clin Pharmacokinet. 1990 Oct;19(4):264–279. doi: 10.2165/00003088-199019040-00002. [DOI] [PubMed] [Google Scholar]
  11. Lee I. S., Hufford C. D. Metabolism of antimalarial sesquiterpene lactones. Pharmacol Ther. 1990;48(3):345–355. doi: 10.1016/0163-7258(90)90053-5. [DOI] [PubMed] [Google Scholar]
  12. Li G. Q., Guo X. B., Jin R., Wang Z. C., Jian H. X., Li Z. Y. Clinical studies on treatment of cerebral malaria with qinghaosu and its derivatives. J Tradit Chin Med. 1982 Jun;2(2):125–130. [PubMed] [Google Scholar]
  13. Luxemburger C., Nosten F., ter Kuiile F., Frejacques L., Chongsuphajaisiddhi T., White N. J. Mefloquine for multidrug-resistant malaria. Lancet. 1991 Nov 16;338(8777):1268–1268. doi: 10.1016/0140-6736(91)92131-k. [DOI] [PubMed] [Google Scholar]
  14. Mihaly G. W., Ward S. A., Edwards G., Orme M. L., Breckenridge A. M. Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite. Br J Clin Pharmacol. 1984 Apr;17(4):441–446. doi: 10.1111/j.1365-2125.1984.tb02369.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Miller K. D., Lobel H. O., Satriale R. F., Kuritsky J. N., Stern R., Campbell C. C. Severe cutaneous reactions among American travelers using pyrimethamine-sulfadoxine (Fansidar) for malaria prophylaxis. Am J Trop Med Hyg. 1986 May;35(3):451–458. doi: 10.4269/ajtmh.1986.35.451. [DOI] [PubMed] [Google Scholar]
  16. Milton K. A., Edwards G., Ward S. A., Orme M. L., Breckenridge A. M. Pharmacokinetics of halofantrine in man: effects of food and dose size. Br J Clin Pharmacol. 1989 Jul;28(1):71–77. doi: 10.1111/j.1365-2125.1989.tb03507.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Nosten F., Karbwang J., White N. J., Honeymoon, Na Bangchang K., Bunnag D., Harinasuta T. Mefloquine antimalarial prophylaxis in pregnancy: dose finding and pharmacokinetic study. Br J Clin Pharmacol. 1990 Jul;30(1):79–85. doi: 10.1111/j.1365-2125.1990.tb03746.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Nosten F., ter Kuile F., Chongsuphajaisiddhi T., Luxemburger C., Webster H. K., Edstein M., Phaipun L., Thew K. L., White N. J. Mefloquine-resistant falciparum malaria on the Thai-Burmese border. Lancet. 1991 May 11;337(8750):1140–1143. doi: 10.1016/0140-6736(91)92798-7. [DOI] [PubMed] [Google Scholar]
  19. Nosten F., ter Kuile F., Chongsuphajaisiddhi T., Na Bangchang K., Karbwang J., White N. J. Mefloquine pharmacokinetics and resistance in children with acute falciparum malaria. Br J Clin Pharmacol. 1991 May;31(5):556–559. doi: 10.1111/j.1365-2125.1991.tb05581.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Peterson D. S., Milhous W. K., Wellems T. E. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3018–3022. doi: 10.1073/pnas.87.8.3018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Phillips R. E., Warrell D. A., White N. J., Looareesuwan S., Karbwang J. Intravenous quinidine for the treatment of severe falciparum malaria. Clinical and pharmacokinetic studies. N Engl J Med. 1985 May 16;312(20):1273–1278. doi: 10.1056/NEJM198505163122001. [DOI] [PubMed] [Google Scholar]
  22. Pussard E., Lepers J. P., Clavier F., Raharimalala L., Le Bras J., Frisk-Holmberg M., Bergqvist Y., Verdier F. Efficacy of a loading dose of oral chloroquine in a 36-hour treatment schedule for uncomplicated plasmodium falciparum malaria. Antimicrob Agents Chemother. 1991 Mar;35(3):406–409. doi: 10.1128/aac.35.3.406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rieckmann K. H., Davis D. R., Hutton D. C. Plasmodium vivax resistance to chloroquine? Lancet. 1989 Nov 18;2(8673):1183–1184. doi: 10.1016/s0140-6736(89)91792-3. [DOI] [PubMed] [Google Scholar]
  24. Salako L. A., Adio R. A., Sowunmi A., Walker O. Parenteral sulphadoxine-pyrimethamine (Fansidar): an effective and safe but under-used method of anti-malarial treatment. Trans R Soc Trop Med Hyg. 1990 Sep-Oct;84(5):641–643. doi: 10.1016/0035-9203(90)90131-w. [DOI] [PubMed] [Google Scholar]
  25. Silamut K., Molunto P., Ho M., Davis T. M., White N. J. Alpha 1-acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria. Br J Clin Pharmacol. 1991 Sep;32(3):311–315. doi: 10.1111/j.1365-2125.1991.tb03904.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Silamut K., White N. J., Looareesuwan S., Warrell D. A. Binding of quinine to plasma proteins in falciparum malaria. Am J Trop Med Hyg. 1985 Jul;34(4):681–686. doi: 10.4269/ajtmh.1985.34.681. [DOI] [PubMed] [Google Scholar]
  27. Slutsker L. M., Khoromana C. O., Payne D., Allen C. R., Wirima J. J., Heymann D. L., Patchen L., Steketee R. W. Mefloquine therapy for Plasmodium falciparum malaria in children under 5 years of age in Malawi: in vivo/in vitro efficacy and correlation of drug concentration with parasitological outcome. Bull World Health Organ. 1990;68(1):53–59. [PMC free article] [PubMed] [Google Scholar]
  28. Supanaranond W., Davis T. M., Pukrittayakamee S., Silamut K., Karbwang J., Molunto P., Chanond L., White N. J. Disposition of oral quinine in acute falciparum malaria. Eur J Clin Pharmacol. 1991;40(1):49–52. doi: 10.1007/BF00315138. [DOI] [PubMed] [Google Scholar]
  29. Walker O., Dawodu A. H., Adeyokunnu A. A., Salako L. A., Alvan G. Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria. Br J Clin Pharmacol. 1983 Dec;16(6):701–705. doi: 10.1111/j.1365-2125.1983.tb02244.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Waller D., Krishna S., Craddock C., Brewster D., Jammeh A., Kwiatkowski D., Karbwang J., Molunto P., White N. J. The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria. Trans R Soc Trop Med Hyg. 1990 Jul-Aug;84(4):488–491. doi: 10.1016/0035-9203(90)90009-4. [DOI] [PubMed] [Google Scholar]
  31. Ward S. A., Helsby N. A., Skjelbo E., Brøsen K., Gram L. F., Breckenridge A. M. The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study. Br J Clin Pharmacol. 1991 Jun;31(6):689–692. doi: 10.1111/j.1365-2125.1991.tb05594.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Warrell D. A., Looareesuwan S., Warrell M. J., Kasemsarn P., Intaraprasert R., Bunnag D., Harinasuta T. Dexamethasone proves deleterious in cerebral malaria. A double-blind trial in 100 comatose patients. N Engl J Med. 1982 Feb 11;306(6):313–319. doi: 10.1056/NEJM198202113060601. [DOI] [PubMed] [Google Scholar]
  33. Watkins W. M., Brandling-Bennett A. D., Nevill C. G., Carter J. Y., Boriga D. A., Howells R. E., Koech D. K. Chlorproguanil/dapsone for the treatment of non-severe Plasmodium falciparum malaria in Kenya: a pilot study. Trans R Soc Trop Med Hyg. 1988;82(3):398–403. doi: 10.1016/0035-9203(88)90133-2. [DOI] [PubMed] [Google Scholar]
  34. Watkins W. M., Chulay J. D., Sixsmith D. G., Spencer H. C., Howells R. E. A preliminary pharmacokinetic study of the antimalarial drugs, proguanil and chlorproguanil. J Pharm Pharmacol. 1987 Apr;39(4):261–265. doi: 10.1111/j.2042-7158.1987.tb06263.x. [DOI] [PubMed] [Google Scholar]
  35. Watkins W. M., Oloo J. A., Lury J. D., Mosoba M., Kariuki D., Mjomba M., Koech D. K., Gilles H. M. Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya. Lancet. 1988 Jul 30;2(8605):247–250. doi: 10.1016/s0140-6736(88)92538-x. [DOI] [PubMed] [Google Scholar]
  36. Wattanagoon Y., Taylor R. B., Moody R. R., Ochekpe N. A., Looareesuwan S., White N. J. Single dose pharmacokinetics of proguanil and its metabolites in healthy subjects. Br J Clin Pharmacol. 1987 Dec;24(6):775–780. doi: 10.1111/j.1365-2125.1987.tb03245.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Weinke T., Trautmann M., Held T., Weber G., Eichenlaub D., Fleischer K., Kern W., Pohle H. D. Neuropsychiatric side effects after the use of mefloquine. Am J Trop Med Hyg. 1991 Jul;45(1):86–91. doi: 10.4269/ajtmh.1991.45.86. [DOI] [PubMed] [Google Scholar]
  38. White N. J., Chanthavanich P., Krishna S., Bunch C., Silamut K. Quinine disposition kinetics. Br J Clin Pharmacol. 1983 Oct;16(4):399–403. doi: 10.1111/j.1365-2125.1983.tb02184.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. White N. J. Clinical pharmacokinetics of antimalarial drugs. Clin Pharmacokinet. 1985 May-Jun;10(3):187–215. doi: 10.2165/00003088-198510030-00001. [DOI] [PubMed] [Google Scholar]
  40. White N. J. Combination treatment for falciparum prophylaxis. Lancet. 1987 Mar 21;1(8534):680–681. doi: 10.1016/s0140-6736(87)90438-7. [DOI] [PubMed] [Google Scholar]
  41. White N. J. Drug treatment and prevention of malaria. Eur J Clin Pharmacol. 1988;34(1):1–14. doi: 10.1007/BF01061409. [DOI] [PubMed] [Google Scholar]
  42. White N. J., Krishna S. Treatment of malaria: some considerations and limitations of the current methods of assessment. Trans R Soc Trop Med Hyg. 1989 Nov-Dec;83(6):767–777. doi: 10.1016/0035-9203(89)90322-2. [DOI] [PubMed] [Google Scholar]
  43. White N. J., Looareesuwan S., Phillips R. E., Chanthavanich P., Warrell D. A. Single dose phenobarbitone prevents convulsions in cerebral malaria. Lancet. 1988 Jul 9;2(8602):64–66. doi: 10.1016/s0140-6736(88)90002-5. [DOI] [PubMed] [Google Scholar]
  44. White N. J., Looareesuwan S., Silamut K. Red cell quinine concentrations in falciparum malaria. Am J Trop Med Hyg. 1983 May;32(3):456–460. doi: 10.4269/ajtmh.1983.32.456. [DOI] [PubMed] [Google Scholar]
  45. White N. J., Looareesuwan S., Warrell D. A., Warrell M. J., Bunnag D., Harinasuta T. Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med. 1982 Oct;73(4):564–572. doi: 10.1016/0002-9343(82)90337-0. [DOI] [PubMed] [Google Scholar]
  46. White N. J., Looareesuwan S., Warrell D. A., Warrell M. J., Chanthavanich P., Bunnag D., Harinasuta T. Quinine loading dose in cerebral malaria. Am J Trop Med Hyg. 1983 Jan;32(1):1–5. doi: 10.4269/ajtmh.1983.32.1. [DOI] [PubMed] [Google Scholar]
  47. White N. J., Miller K. D., Churchill F. C., Berry C., Brown J., Williams S. B., Greenwood B. M. Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. N Engl J Med. 1988 Dec 8;319(23):1493–1500. doi: 10.1056/NEJM198812083192301. [DOI] [PubMed] [Google Scholar]
  48. White N. J., Watt G., Bergqvist Y., Njelesani E. K. Parenteral chloroquine for treating falciparum malaria. J Infect Dis. 1987 Feb;155(2):192–201. doi: 10.1093/infdis/155.2.192. [DOI] [PubMed] [Google Scholar]
  49. Winstanley P. A., Watkins W. M., Newton C. R., Nevill C., Mberu E., Warn P. A., Waruiru C. M., Mwangi I. N., Warrell D. A., Marsh K. The disposition of oral and intramuscular pyrimethamine/sulphadoxine in Kenyan children with high parasitaemia but clinically non-severe falciparum malaria. Br J Clin Pharmacol. 1992 Feb;33(2):143–148. doi: 10.1111/j.1365-2125.1992.tb04016.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Winstanley P., Edwards G., Orme M., Breckenridge A. The disposition of amodiaquine in man after oral administration. Br J Clin Pharmacol. 1987 Jan;23(1):1–7. doi: 10.1111/j.1365-2125.1987.tb03002.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Wirima J., Khoromana C., Molyneux M. E., Gilles H. M. Clinical trials with halofantrine hydrochloride in Malawi. Lancet. 1988 Jul 30;2(8605):250–252. doi: 10.1016/s0140-6736(88)92539-1. [DOI] [PubMed] [Google Scholar]
  52. Yayon A., Vande Waa J. A., Yayon M., Geary T. G., Jensen J. B. Stage-dependent effects of chloroquine on Plasmodium falciparum in vitro. J Protozool. 1983 Nov;30(4):642–647. doi: 10.1111/j.1550-7408.1983.tb05336.x. [DOI] [PubMed] [Google Scholar]
  53. Zhang Y., Asante K. S., Jung A. Stage-dependent inhibition of chloroquine on Plasmodium falciparum in vitro. J Parasitol. 1986 Dec;72(6):830–836. [PubMed] [Google Scholar]

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