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. 1992 Jul;34(1):60–64. doi: 10.1111/j.1365-2125.1992.tb04108.x

Enhancement of the oral absorption of cyclosporin in man.

J Drewe 1, R Meier 1, J Vonderscher 1, D Kiss 1, U Posanski 1, T Kissel 1, K Gyr 1
PMCID: PMC1381376  PMID: 1633069

Abstract

1. The oral absorption of cyclosporin from three new semi-solid oral formulations was compared with the standard soft gelatine preparation in twelve healthy male volunteers. One formulation was based on a solid micellar solution, while the other two, with different in vitro release properties, were based on a microemulsion principle. 2. The results showed that the solid micellar solution and the faster releasing microemulsion formulation increased the extent of absorption on average by 45.2 and 49.0%, respectively, compared with the reference soft gelatine capsule.

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Selected References

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