Abstract
After a 30 min i.v. infusion of 1 g cloxacillin, the concentrations of this antibiotic were measured in plasma and synovial tissue samples from 11 patients undergoing total hip replacement. Assuming passive distribution between plasma and tissue the rate constants of distribution were estimated. The mean half-life of distribution was 22 min. The concentration of free drug in synovial tissue was estimated to be 77% of the total tissue concentration. The maximum tissue drug concentration after an i.v. bolus dose is predicted to occur at about 37 min.
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Selected References
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- Bergamini T. M., Polk H. C., Jr The importance of tissue antibiotic activity in the prevention of operative wound infection. J Antimicrob Chemother. 1989 Mar;23(3):301–313. doi: 10.1093/jac/23.3.301. [DOI] [PubMed] [Google Scholar]
- Kullberg B. J., Mattie H., Huysmans H. A., van Furth R. Evaluation of cloxacillin concentrations in plasma and muscle tissue during cardiopulmonary bypass. Scand J Infect Dis. 1991;23(2):233–238. doi: 10.3109/00365549109023406. [DOI] [PubMed] [Google Scholar]
- Kunst M. W., Mattie H. Cefazolin and cephradine: relationship between serum concentrations and tissue contents in mice. Infection. 1978;6(4):166–170. doi: 10.1007/BF01641906. [DOI] [PubMed] [Google Scholar]
- Mattie H., Hoogeterp J. J., Hermans J. The relation between plasma and tissue concentrations of antibiotics. Description of a method. J Pharmacokinet Biopharm. 1987 Apr;15(2):191–202. doi: 10.1007/BF01062343. [DOI] [PubMed] [Google Scholar]
- Mattie H., Hoogeterp J. J., Kaajan J. P., Hermans J. The penetration of erythromycin into human bronchial mucosa. Br J Clin Pharmacol. 1987 Aug;24(2):179–183. doi: 10.1111/j.1365-2125.1987.tb03159.x. [DOI] [PMC free article] [PubMed] [Google Scholar]