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. 1993 Feb;35(2):184–187. doi: 10.1111/j.1365-2125.1993.tb05684.x

Modulation of capsaicin induced airway reflexes in humans: effect of monoamine oxidase inhibition.

N B Choudry 1, J Studham 1, D Harland 1, R W Fuller 1
PMCID: PMC1381512  PMID: 8443037

Abstract

1. In animal studies monoamine oxidase (MAO) inhibition has been shown to reduce the cough response through elevation of 5-HT in the central nervous system. In this study the effect of selective inhibition of the two subtypes of MAO (MAO-A and MAO-B) was studied on human airway reflexes. 2. Capsaicin-induced cough and reflex increase in respiratory resistance were measured in nine normal volunteers before and after MDL 72394 (MAO-A inhibitor) 16 mg or MDL 72974A (MAO-B inhibitor) 12 mg. 3. Neither inhibitor altered capsaicin-induced cough. Following treatment with MDL 72394, however, the capsaicin-induced reflex increase in resistance was enhanced, by 5.97 +/- 2.1 fold of the placebo value at 1 h. 4. Thus, neurotransmitters in the central nervous system which are substrate for MAO-A (i.e. noradrenaline, 5-HT) may be involved in the control of capsaicin-induced reflex bronchoconstriction.

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Selected References

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  1. Bolme P., Corrodi H., Fuxe K., Hökfelt T., Lidbrink P., Goldstein M. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine. Eur J Pharmacol. 1974 Sep;28(1):89–94. doi: 10.1016/0014-2999(74)90116-2. [DOI] [PubMed] [Google Scholar]
  2. Choudry N. B., McEwan J. R., Lavender E. A., Williams A. J., Fuller R. W. Human responses to inhaled capsaicin are not inhibited by granisetron. Br J Clin Pharmacol. 1991 Mar;31(3):337–339. doi: 10.1111/j.1365-2125.1991.tb05538.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Christian E. P., Taylor G. E., Weinreich D. Serotonin increases excitability of rabbit C-fiber neurons by two distinct mechanisms. J Appl Physiol (1985) 1989 Aug;67(2):584–591. doi: 10.1152/jappl.1989.67.2.584. [DOI] [PubMed] [Google Scholar]
  4. Collier J. G., Fuller R. W. Capsaicin inhalation in man and the effects of sodium cromoglycate. Br J Pharmacol. 1984 Jan;81(1):113–117. doi: 10.1111/j.1476-5381.1984.tb10750.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Denney R. M., Denney C. B. An update on the identity crisis of monoamine oxidase: new and old evidence for the independence of MAO A and B. Pharmacol Ther. 1985;30(3):227–258. doi: 10.1016/0163-7258(85)90050-6. [DOI] [PubMed] [Google Scholar]
  6. Dinh Xuan A. T., Matran R., Regnard J., Vitou P., Advenier C., Lockhart A. Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects. Br J Clin Pharmacol. 1988 Dec;26(6):703–708. doi: 10.1111/j.1365-2125.1988.tb05308.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fowler C. J., Ross S. B. Selective inhibitors of monoamine oxidase A and B: biochemical, pharmacological, and clinical properties. Med Res Rev. 1984 Jul-Sep;4(3):323–358. doi: 10.1002/med.2610040303. [DOI] [PubMed] [Google Scholar]
  8. Fuller R. W., Dixon C. M., Barnes P. J. Bronchoconstrictor response to inhaled capsaicin in humans. J Appl Physiol (1985) 1985 Apr;58(4):1080–1084. doi: 10.1152/jappl.1985.58.4.1080. [DOI] [PubMed] [Google Scholar]
  9. Fuller R. W., Jackson D. M. Physiology and treatment of cough. Thorax. 1990 Jun;45(6):425–430. doi: 10.1136/thx.45.6.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fuller R. W., Karlsson J. A., Choudry N. B., Pride N. B. Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans. J Appl Physiol (1985) 1988 Sep;65(3):1125–1130. doi: 10.1152/jappl.1988.65.3.1125. [DOI] [PubMed] [Google Scholar]
  11. Ho B. Y., Takemori A. E. Serotonergic involvement in the antinociceptive action of and the development of tolerance to the kappa-opioid receptor agonist, U-50, 488H. J Pharmacol Exp Ther. 1989 Aug;250(2):508–514. [PubMed] [Google Scholar]
  12. Kamei J., Hosokawa T., Yanaura S., Hukuhara T. Involvement of central serotonergic mechanisms in the cough reflex. Jpn J Pharmacol. 1986 Dec;42(4):531–538. doi: 10.1254/jjp.42.531. [DOI] [PubMed] [Google Scholar]
  13. Kamei J., Ogawa M., Kasuya Y. Supersensitivity of 5,7-dihydroxytryptamine-treated rats to the respiratory depressant and antitussive effects of dihydrocodeine. Eur J Pharmacol. 1988 Aug 24;153(2-3):305–308. doi: 10.1016/0014-2999(88)90620-6. [DOI] [PubMed] [Google Scholar]
  14. Kamei J., Tanihara H., Kasuya Y. Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats. Eur J Pharmacol. 1990 Oct 9;187(2):281–286. doi: 10.1016/0014-2999(90)90014-w. [DOI] [PubMed] [Google Scholar]
  15. Kilpatrick G. J., Jones B. J., Tyers M. B. Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species. Eur J Pharmacol. 1989 Jan 10;159(2):157–164. doi: 10.1016/0014-2999(89)90700-0. [DOI] [PubMed] [Google Scholar]
  16. Lándsér F. J., Nagles J., Demedts M., Billiet L., van de Woestijne K. P. A new method to determine frequency characteristics of the respiratory system. J Appl Physiol. 1976 Jul;41(1):101–106. doi: 10.1152/jappl.1976.41.1.101. [DOI] [PubMed] [Google Scholar]
  17. Palfreyman M. G., McDonald I. A., Fozard J. R., Mely Y., Sleight A. J., Zreika M., Wagner J., Bey P., Lewis P. J. Inhibition of monoamine oxidase selectively in brain monoamine nerves using the bioprecursor (E)-beta-fluoromethylene-m-tyrosine (MDL 72394), a substrate for aromatic L-amino acid decarboxylase. J Neurochem. 1985 Dec;45(6):1850–1860. doi: 10.1111/j.1471-4159.1985.tb10543.x. [DOI] [PubMed] [Google Scholar]
  18. Sheller J. R., Holtzman M. J., Skoogh B. E., Nadel J. A. Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs. J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr;52(4):964–966. doi: 10.1152/jappl.1982.52.4.964. [DOI] [PubMed] [Google Scholar]
  19. Sheppard D., Rizk N. W., Boushey H. A., Bethel R. A. Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis. 1983 Jun;127(6):691–694. doi: 10.1164/arrd.1983.127.6.691. [DOI] [PubMed] [Google Scholar]
  20. Vonvoigtlander P. F., Lewis R. A., Neff G. L. Kappa opioid analgesia is dependent on serotonergic mechanisms. J Pharmacol Exp Ther. 1984 Nov;231(2):270–274. [PubMed] [Google Scholar]
  21. Zreika M., Fozard J. R., Dudley M. W., Bey P., McDonald I. A., Palfreyman M. G. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease. J Neural Transm Park Dis Dement Sect. 1989;1(4):243–254. doi: 10.1007/BF02263478. [DOI] [PubMed] [Google Scholar]

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