Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1993 Apr;35(4):400–408. doi: 10.1111/j.1365-2125.1993.tb04157.x

A population based case-cohort study of drug-induced anaphylaxis.

M M van der Klauw 1, B H Stricker 1, R M Herings 1, W S Cost 1, H A Valkenburg 1, J H Wilson 1
PMCID: PMC1381551  PMID: 8097922

Abstract

1. In order to determine the risk of anaphylaxis as an adverse reaction to drugs, a case-cohort study was performed. Cases consisted of all admissions in 1987 and 1988 to all Dutch hospitals with anaphylaxis as the principal diagnosis, and a random sample of admissions with related symptoms. Hospital discharge summaries were classified according to probability to anaphylaxis by a blinded Audit Committee. Of admissions classified as probable or possible anaphylaxis, the causative agent was assessed. The reference cohort consisted of all persons in the catchment area of a sample of pharmacies in The Netherlands, in the period between January 1, 1987 and December 31, 1988. 2. Out of 934 admissions, discharge summaries on 811 admissions were received, of which 727 contained enough clinical details. Out of 727, 391 were classified as probable or possible anaphylaxis. In 336 of these 391, anaphylaxis was reason for admission. This group consisted of 158 men and 178 women. Drug-induced anaphylaxis occurred in 107 patients. 3. Drug-induced anaphylaxis was most frequently caused by penicillins, analgesics and non-steroidal antiinflammatory drugs (NSAID) with the highest point estimate of the risk relative to all other drugs of 10.7, 6.9 and 3.7 respectively. 4. In the cases of probable anaphylaxis, the risk of anaphylaxis to glafenine relative to all other drugs was 167.7 in 1987 (95%-CI: 63.0-446.4) and 128.6 in 1988 (95%-CI: 50.4-328.5), to amoxycillin 15.2 in 1987 (95%-CI: 5.0-46.0) and 4.4 in 1988 (95%-CI: 1.03-18.9) and to diclofenac 6.1 in 1988 (95%-CI: 1.4-26.1).(ABSTRACT TRUNCATED AT 250 WORDS)

Full text

PDF
400

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barral C., Faivre M. Accidents anaphylactiques imputés à la glafénine. Cinq cas. Nouv Presse Med. 1975 Nov 15;4(39):2797–2798. [PubMed] [Google Scholar]
  2. Bochner B. S., Lichtenstein L. M. Anaphylaxis. N Engl J Med. 1991 Jun 20;324(25):1785–1790. doi: 10.1056/NEJM199106203242506. [DOI] [PubMed] [Google Scholar]
  3. Brown William J., Simpson W. G., Price Eleanor V. Reevaluation of reactions to penicillin in venereal disease clinic patients. Public Health Rep. 1961 Mar;76(3):189–198. [PMC free article] [PubMed] [Google Scholar]
  4. Bégaud B., Evreux J. C., Jouglard J., Lagier G. Imputabilité des effets inattendus ou toxiques des médicaments. Actualisation de la méthode utilisée en France. Therapie. 1985 Mar-Apr;40(2):111–118. [PubMed] [Google Scholar]
  5. Cheymol G., Biour M., Bruneel M., Albengres E., Hamel J. D. Bilan d'une enquête nationale prospective sur les effets indésirables de la glafénine, de l'antrafénine et de la floctafénine. Therapie. 1985 Jan-Feb;40(1):45–50. [PubMed] [Google Scholar]
  6. Davido A., Hallali P., Boutchnei T. Les chocs à la glafénine. A propos de sept accidents. Rev Med Interne. 1989 Mar-Apr;10(2):113–117. doi: 10.1016/s0248-8663(89)80090-6. [DOI] [PubMed] [Google Scholar]
  7. Fischbein L., Brechenmacher C., Voegtlin R. Ischémie myocardique aiguë au cours d'une réaction anaphylactique d'origine médicamenteuse. Presse Med. 1984 Apr 21;13(17):1100–1100. [PubMed] [Google Scholar]
  8. Gaultier M., Bismuth C., Efthymiou M. L., Morel-Maroger L., Romion A. Néphropathie tubulo-interstitielle aiguë au cours d'une intoxication par la glafénine. Nouv Presse Med. 1972 Dec 23;1(46):3125–3128. [PubMed] [Google Scholar]
  9. Grand A., Despret P. Choc analphylactique induit par la glafénine. Nouv Presse Med. 1973 Apr;2(16):1075–1075. [PubMed] [Google Scholar]
  10. Herings R. M., Bakker A., Stricker B. H., Nap G. Pharmaco-morbidity linkage: a feasibility study comparing morbidity in two pharmacy based exposure cohorts. J Epidemiol Community Health. 1992 Apr;46(2):136–140. doi: 10.1136/jech.46.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Journe B., Bertault R., Dihn Van Kieu C. D., Buffet M., Seys G. A. OEdeme pulmonaire lésionnel au cours d'un choc anaphylactique. Une observation. Nouv Presse Med. 1980 Oct 11;9(37):2744–2744. [PubMed] [Google Scholar]
  12. Lainée R., Desaint M. M., Godard S., Le Tessier G., Ertel M., Hooreman H., Sablon P., Bellorini M., Lévy M., Besse F. Infarctus myocardique transmural et syndrome de Prinzmetal au cours d'une réaction allergique à la glafénine. Discussion physiopathologique. A propos d'un cas. Arch Mal Coeur Vaiss. 1985 Jun;78(6):955–959. [PubMed] [Google Scholar]
  13. Maesen F., Mol J. M., Brombacher P. J., Bok E. J., van de Voorden J. M., Vijgen J. H. Anafylactische shock na gebruik van glafenine (Glifanan) Ned Tijdschr Geneeskd. 1976 Jul 24;120(30):1300–1303. [PubMed] [Google Scholar]
  14. Meyboom R. H. Anafylaxie na het gebruik nan glafenine. Ned Tijdschr Geneeskd. 1976 May 22;120(21):926–927. [PubMed] [Google Scholar]
  15. Michaud J. L., Doublet L. Choc induit par la glafénine. Six nouveaux cas. Nouv Presse Med. 1976 Mar 13;5(11):716–716. [PubMed] [Google Scholar]
  16. Miettinen O. Design options in epidemiologic research. An update. Scand J Work Environ Health. 1982;8 (Suppl 1):7–14. [PubMed] [Google Scholar]
  17. Sauder P., Kopferschmitt J., Sagez J. F., Benmatti A., Jaeger A., Mantz J. M. Aspects hémodynamiques du choc anaphylactique. A propos d'un cas par glafénine. Rev Med Interne. 1982;3(3):241–243. doi: 10.1016/s0248-8663(82)80023-4. [DOI] [PubMed] [Google Scholar]
  18. Saxon A., Beall G. N., Rohr A. S., Adelman D. C. Immediate hypersensitivity reactions to beta-lactam antibiotics. Ann Intern Med. 1987 Aug;107(2):204–215. doi: 10.7326/0003-4819-107-2-204. [DOI] [PubMed] [Google Scholar]
  19. Sentilhes C. Etats de choc induits par la glafénine et ses dérivés. Rev Odontostomatol (Paris) 1978 May-Jun;7(3):225–226. [PubMed] [Google Scholar]
  20. Stricker B. H., de Groot R. R., Wilson J. H. Glafenine-associated anaphylaxis as a cause of hospital admission in The Netherlands. Eur J Clin Pharmacol. 1991;40(4):367–371. doi: 10.1007/BF00265845. [DOI] [PubMed] [Google Scholar]
  21. Weber S., Genevray B., Pasquier G., Chapsal J., Bonnin A., Degeorges M. Severe coronary spasm during drug-induced immediate hypersensitivity reaction. Lancet. 1982 Oct 9;2(8302):821–821. doi: 10.1016/s0140-6736(82)92709-x. [DOI] [PubMed] [Google Scholar]
  22. Weiss M. E., Adkinson N. F. Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Allergy. 1988 Nov;18(6):515–540. doi: 10.1111/j.1365-2222.1988.tb02904.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES